Publications by authors named "Nicolas Desroy"

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Benthic ecological changes in response to fish farming waste deposition in tropical environment: combining field and modelling approaches.
Mélina Grouazel, Nicolas Desroy, Annie Fiandrino, Thibault Geoffroy, Sarah Nahon

Mar Pollut Bull· January 2026

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Discovery of GLPG4471, a potent and selective IRAK4 inhibitor for the treatment of inflammatory and autoimmune diseases.
Oscar Mammoliti, Florence Bonnaterre, Gregory Newsome, Rhalid Akkari, Miriam López-Ramos, Nicolas Desroy

Bioorg Med Chem Lett· December 2025

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Structure activity relationship exploration of imidazo[1,2-a]pyridine series to reverse isoform selectivity and identify potent SIK1 selective inhibitors.
Christophe Peixoto, Elsa De Lemos, Laëtitia Cherel, Gregory Newsome, Aurelie Dos Santos, Nicolas Desroy

Bioorg Med Chem Lett· December 2025

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Structure-Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 Inhibitor.
Hans Kelgtermans, Maxim De Wachter, Stijn Heyndrickx, Sandy El Bkassiny, Tatiana Lacarriere, Nicolas Desroy

J Med Chem· August 2025

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Design, Synthesis, and Biological Implications of Autotaxin inhibitors with a Three-Point lock binding mode.
Nicolas Desroy, Razvan Borza, Jörg Heiermann, Nicolas Triballeau, Agnès Joncour

Bioorg Med Chem· July 2025

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Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases.
Christophe Peixoto, Agnes Joncour, Taouès Temal-Laib, Amynata Tirera, Aurélie Dos Santos, Nicolas Desroy

J Med Chem· April 2024

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Sediment grain size and benthic community structure in the eastern English Channel: Species-dependent responses and environmental influence.
Nathan Chauvel, Aurore Raoux, Pierre Weill, Laurent Dezilleau, Yann Méar, Nicolas Desroy

Mar Pollut Bull· March 2024

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Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
Taouès Temal-Laib, Christophe Peixoto, Nicolas Desroy, Elsa De Lemos, Florence Bonnaterre

J Med Chem· January 2024

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Sediment migrations drive the dynamic of macrobenthic ecosystems in subtidal sandy bedforms.
Alexandre Elie Robert, Nolwenn Quillien, Mahmoud Bacha, Clémence Caulle, Maëlle Nexer, Nicolas Desroy

Mar Pollut Bull· October 2021

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Linking multiple facets of biodiversity and ecosystem functions in a coastal reef habitat.
Auriane G Jones, Lionel Denis, Jérôme Fournier, Nicolas Desroy, Gwendoline Duong

Mar Environ Res· December 2020

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Long-term spatio-temporal changes of the muddy fine sand benthic community of the Bay of Seine (eastern English Channel).
Lise Bacouillard, Noémie Baux, Jean-Claude Dauvin, Nicolas Desroy, Katja Juliana Geiger

Mar Environ Res· October 2020

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Renewable energy homes for marine life: Habitat potential of a tidal energy project for benthic megafauna.
Bastien Taormina, Martial Laurans, Martin P Marzloff, Noémie Dufournaud, Morgane Lejart, Nicolas Desroy

Mar Environ Res· October 2020

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Impact of magnetic fields generated by AC/DC submarine power cables on the behavior of juvenile European lobster (Homarus gammarus).
Bastien Taormina, Carole Di Poi, Ann-Lisbeth Agnalt, Antoine Carlier, Nicolas Desroy

Aquat Toxicol· March 2020

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Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators.
Gert de Wilde, Maarten Gees, Sara Musch, Katleen Verdonck, Mia Jans, Nicolas Desroy

Front Pharmacol· May 2019

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Individual-based simulation of the spatial and temporal dynamics of macroinvertebrate functional groups provides insights into benthic community assembly mechanisms.
Nikolaos Alexandridis, Cédric Bacher, Nicolas Desroy, Fred Jean

PeerJ· June 2018

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Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.
Agnès Joncour, Nicolas Desroy, Christopher Housseman, Xavier Bock, Natacha Bienvenu

J Med Chem· May 2018

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Latitudinal Patterns in European Seagrass Carbon Reserves: Influence of Seasonal Fluctuations versus Short-Term Stress and Disturbance Events.
Laura M Soissons, Eeke P Haanstra, Marieke M van Katwijk, Ragnhild Asmus, Isabelle Auby, Nicolas Desroy

Front Plant Sci· February 2018

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Process-driven and biological characterisation and mapping of seabed habitats sensitive to trawling.
Aurélie Foveau, Sandrine Vaz, Nicolas Desroy, Vladimir E Kostylev

PLoS One· October 2017

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Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.
Agnès Joncour, Nicolas Desroy, Christopher Housseman, Xavier Bock, Natacha Bienvenu

J Med Chem· September 2017

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Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.
Nicolas Desroy, Christopher Housseman, Xavier Bock, Agnès Joncour, Natacha Bienvenu

J Med Chem· May 2017

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Structural-functional studies of Burkholderia cenocepacia D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.
Ting-Wai Lee, Theodore B Verhey, Pavel A Antiperovitch, Dmytro Atamanyuk, Nicolas Desroy

J Med Chem· February 2013

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Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence.
Nicolas Desroy, Alexis Denis, Chrystelle Oliveira, Dmytro Atamanyuk, Sophia Briet

J Med Chem· February 2013

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From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.
Vincent Gerusz, Alexis Denis, Fabien Faivre, Yannick Bonvin, Mayalen Oxoby, Nicolas Desroy

J Med Chem· November 2012

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Ephemeral bio-engineers or reef-building polychaetes: how stable are aggregations of the tube worm Lanice conchilega (Pallas, 1766)?
Ruth Callaway, Nicolas Desroy, Stanislas F Dubois, Jérôme Fournier, Matthew Frost

Integr Comp Biol· August 2010

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Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase.
Nicolas Desroy, François Moreau, Sophia Briet, Géraldine Le Fralliec, Stephanie Floquet

Bioorg Med Chem· February 2009

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