Publications by authors named "Alexis Denis"

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Structure-Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 Inhibitor.
Hans Kelgtermans, Maxim De Wachter, Stijn Heyndrickx, Sandy El Bkassiny, Tatiana Lacarriere, Denis Bucher, Alexis Denis

J Med Chem· August 2025

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Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers.
Maria M Haykal, Sylvie Rodrigues-Ferreira, Rania El Botty, Laura Sourd, Elisabetta Marangoni, Alexis Denis

Cancer Lett· June 2025

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A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
John Liddle, Veronique Beneton, Matthew Benson, Ryan Bingham, Anne Bouillot, Alexis Denis

J Invest Dermatol· September 2021

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The development of highly potent and selective small molecule correctors of Z α-antitrypsin misfolding.
John Liddle, Andrew C Pearce, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, Alexis Denis

Bioorg Med Chem Lett· June 2021

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Development of a small molecule that corrects misfolding and increases secretion of Z α -antitrypsin.
David A Lomas, James A Irving, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, Alexis Denis

EMBO Mol Med· March 2021

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Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection.
Philippe Karoyan, Vincent Vieillard, Luis Gómez-Morales, Estelle Odile, Amélie Guihot, Alexis Denis

Commun Biol· February 2021

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Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675].
Ann L Walker, Alexis Denis, Ryan P Bingham, Anne Bouillot, Emma V Edgar

Bioorg Med Chem Lett· January 2020

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Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Ann L Walker, Alexis Denis, Ryan P Bingham, Anne Bouillot, Emma V Edgar

Bioorg Med Chem Lett· October 2019

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The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
John Liddle, Benjamin Beaufils, Margaret Binnie, Anne Bouillot, Alexis A Denis

Bioorg Med Chem Lett· May 2017

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Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
Ann L Walker, Nicolas Ancellin, Benjamin Beaufils, Marylise Bergeal, Margaret Binnie, Alexis Denis

J Med Chem· April 2017

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Corrigendum: A unique peptide deformylase platform to rationally design and challenge novel active compounds.
Sonia Fieulaine, Rodolphe Alves de Sousa, Laure Maigre, Karim Hamiche, Mickael Alimi, Alexis Denis

Sci Rep· January 2017

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A unique peptide deformylase platform to rationally design and challenge novel active compounds.
Sonia Fieulaine, Rodolphe Alves de Sousa, Laure Maigre, Karim Hamiche, Mickael Alimi, Alexis Denis

Sci Rep· October 2016

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Structural-functional studies of Burkholderia cenocepacia D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.
Ting-Wai Lee, Theodore B Verhey, Pavel A Antiperovitch, Dmytro Atamanyuk, Nicolas Desroy, Alexis Denis

J Med Chem· February 2013

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Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence.
Nicolas Desroy, Alexis Denis, Chrystelle Oliveira, Dmytro Atamanyuk, Sophia Briet

J Med Chem· February 2013

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From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.
Vincent Gerusz, Alexis Denis, Fabien Faivre, Yannick Bonvin, Mayalen Oxoby

J Med Chem· November 2012

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Towards Gram-positive antivirulence drugs: new inhibitors of Streptococcus agalactiae Stk1.
Mayalen Oxoby, François Moreau, Lionel Durant, Alexis Denis, Jean-Marie Genevard

Bioorg Med Chem Lett· June 2010

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Structure-activity relationship analysis of the peptide deformylase inhibitor 5-bromo-1H-indole-3-acetohydroxamic acid.
Sylvain Petit, Yann Duroc, Valéry Larue, Carmela Giglione, Carole Léon, Alexis Denis

ChemMedChem· February 2009

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Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase.
Nicolas Desroy, François Moreau, Sophia Briet, Géraldine Le Fralliec, Stephanie Floquet, Alexis Denis

Bioorg Med Chem· February 2009

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Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.
Anne-Claude Dublanchet, Pierre Ducrot, Charles Andrianjara, Margaret O'Gara, Renaud Morales, Alexis Denis

Bioorg Med Chem Lett· August 2005

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Synthesis of 9-oxime-11,12-carbamate ketolides through a novel N-deamination reaction of 11,12-hydrazonocarbamate ketolide.
Alexis Denis, Jean-Marie Pejac, François Bretin, Alain Bonnefoy

Bioorg Med Chem· May 2003

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