Publications by authors named "Ryan Bingham"

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Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
Ann M Rowley, Gang Yao, Logan Andrews, Aaron Bedermann, Ross Biddulph, Ryan Bingham

J Med Chem· February 2024

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Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
Mohammed Ghiboub, Jan Koster, Peter D Craggs, Andrew Y F Li Yim, Anthony Shillings, Ryan P Bingham

BMC Biol· August 2022

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Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation.
Lasse Stach, Emily K H Dinley, Nadia Tournier, Ryan P Bingham, Darren A Gormley

Antibodies (Basel)· October 2021

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A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
John Liddle, Veronique Beneton, Matthew Benson, Ryan Bingham, Anne Bouillot

J Invest Dermatol· September 2021

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Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System.
Luke A Greenhough, Gabriella Clarke, Alexander N Phillipou, Faith Mazani, Bhumika Karamshi, Ryan P Bingham

SLAS Discov· June 2021

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Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675].
Ann L Walker, Alexis Denis, Ryan P Bingham, Anne Bouillot, Emma V Edgar

Bioorg Med Chem Lett· January 2020

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Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Ann L Walker, Alexis Denis, Ryan P Bingham, Anne Bouillot, Emma V Edgar

Bioorg Med Chem Lett· October 2019

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Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes.
Alessandra Corazza, Guglielmo Verona, Christopher A Waudby, P Patrizia Mangione, Ryan Bingham

J Med Chem· September 2019

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Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.
Ann L Walker, Ryan P Bingham, Emma V Edgar, Alan Ferrie, Duncan S Holmes

Bioorg Med Chem Lett· June 2019

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Susan Wyllie, Stephen Brand, Michael Thomas, Manu De Rycker, Chun-Wa Chung, Ryan P Bingham

Proc Natl Acad Sci U S A· May 2019

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Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.
Olivia Monteiro, Changwei Chen, Ryan Bingham, Argyrides Argyrou, Rachel Buxton

Neurosci Lett· April 2018

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Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors.
Hongfeng Deng, Jingye Zhou, Flora Sundersingh, Jeffrey A Messer, Donald O Somers, Ryan Bingham

ACS Med Chem Lett· April 2016

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Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.
Jennifer A Borthwick, Nicolas Ancellin, Sophie M Bertrand, Ryan P Bingham, Paul S Carter

J Med Chem· March 2016

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The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.
Sophie M Bertrand, Nicolas Ancellin, Benjamin Beaufils, Ryan P Bingham, Jennifer A Borthwick

J Med Chem· September 2015

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Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.
Hongfeng Deng, Jingye Zhou, Flora S Sundersingh, Jennifer Summerfield, Don Somers, Ryan Bingham

ACS Med Chem Lett· August 2015

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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Huw D Lewis, John Liddle, Jim E Coote, Stephen J Atkinson, Michael D Barker, Ryan P Bingham

Nat Chem Biol· March 2015

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A modular, fully integrated ultra-high-throughput screening system based on confocal fluorescence analysis techniques.
Stefan Jäger, Norbert Garbow, Achim Kirsch, Hartwig Preckel, Frank U Gandenberger, Ryan P Bingham

J Biomol Screen· December 2003

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Single-molecule detection technologies in miniaturized high-throughput screening: fluorescence intensity distribution analysis.
Ulrich Haupts, Martin Rüdiger, Stephen Ashman, Sandra Turconi, Ryan Bingham

J Biomol Screen· February 2003

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