Publications by authors named "James A Irving"

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The mechanism of pathogenic α-antitrypsin aggregation in the human liver.
Ibrahim Aldobiyan, Emma L K Elliston, Narinder Heyer-Chauhan, Stefan T Arold, Lingyun Zhao, James A Irving

Proc Natl Acad Sci U S A· November 2025

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Susceptibility of alpha-1 antitrypsin deficiency variants to polymer-blocking therapy.
Riccardo Ronzoni, Ibrahim Aldobiyan, Elena Miranda, Narinder Heyer-Chauhan, Emma Lk Elliston, James A Irving

JCI Insight· August 2025

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Top-Down Ion Mobility Mass Spectrometry Reveals a Disease Associated Conformational Ensemble of Alpha-1-antitrypsin.
Sarah Vickers, Ibrahim Aldobiyan, Sarah M Lowen, James A Irving, David A Lomas

J Am Chem Soc· May 2025

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High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy.
Sarah M Lowen, Christopher A Waudby, Alistair M Jagger, Ibrahim Aldobiyan, Mattia Laffranchi, James A Irving

Sci Adv· May 2025

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Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface.
Roberto Gangemi, Mattia Bignotti, Andrea Denardo, Claudia N Pearce, Riccardo Ronzoni, James A Irving

FEBS J· April 2025

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Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors.
Deniz Kent, Soon Seng Ng, Adam M Syanda, Payam Khoshkenar, Riccardo Ronzoni, James A Irving

Hepatology· March 2025

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A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate.
Kamila Kamuda, Riccardo Ronzoni, Avik Majumdar, Fiona H X Guan, James A Irving

FEBS J· July 2024

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Probing of the reactive center loop region of alpha-1-antitrypsin by mutagenesis predicts new type-2 dysfunctional variants.
Andrea Denardo, Emna Ben Khlifa, Mattia Bignotti, Roberta Giuliani, Emanuela D'Acunto, James A Irving

Cell Mol Life Sci· December 2023

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Comprehensive Clinical Diagnostic Pipelines Reveal New Variants in Alpha-1 Antitrypsin Deficiency.
Stefania Ottaviani, Giulia Bartoli, Tomás P Carroll, Fabrizio Gangemi, Alice M Balderacchi, James A Irving

Am J Respir Cell Mol Biol· September 2023

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The under-appreciated world of the serpin family of serine proteinase inhibitors.
Marie-Christine Bouton, Margarethe Geiger, William P Sheffield, James A Irving, David A Lomas

EMBO Mol Med· June 2023

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Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation.
Alina Chrzastek, Ioanna A Thanasi, James A Irving, Vijay Chudasama, James R Baker

Chem Sci· October 2022

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Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.
Iwona Maria Pranke, Benoit Chevalier, Aiswarya Premchandar, Nesrine Baatallah, Kamil F Tomaszewski, James A Irving

Cell Mol Life Sci· September 2022

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The development of highly potent and selective small molecule correctors of Z α-antitrypsin misfolding.
John Liddle, Andrew C Pearce, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, James A Irving

Bioorg Med Chem Lett· June 2021

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Scaling Concepts in Serpin Polymer Physics.
Samuele Raccosta, Fabio Librizzi, Alistair M Jagger, Rosina Noto, Vincenzo Martorana, James A Irving

Materials (Basel)· May 2021

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The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant.
Riccardo Ronzoni, Ilaria Ferrarotti, Emanuela D'Acunto, Alice M Balderacchi, Stefania Ottaviani, James A Irving

Int J Mol Sci· May 2021

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The molecular species responsible for α -antitrypsin deficiency are suppressed by a small molecule chaperone.
Riccardo Ronzoni, Nina Heyer-Chauhan, Annamaria Fra, Andrew C Pearce, Martin Rüdiger, James A Irving

FEBS J· April 2021

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Development of a small molecule that corrects misfolding and increases secretion of Z α -antitrypsin.
David A Lomas, James A Irving, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster

EMBO Mol Med· March 2021

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Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes.
Wendy M McKimpson, Yun Chen, James A Irving, Min Zheng, Jeremy Weinberger

Dev Cell· March 2021

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High-resolution ex vivo NMR spectroscopy of human Z α-antitrypsin.
Alistair M Jagger, Christopher A Waudby, James A Irving, John Christodoulou, David A Lomas

Nat Commun· December 2020

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The structural basis for Z α-antitrypsin polymerization in the liver.
Sarah V Faull, Emma L K Elliston, Bibek Gooptu, Alistair M Jagger, Ibrahim Aldobiyan, James A Irving

Sci Adv· October 2020

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Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
Mattia Laffranchi, Emma Lk Elliston, Elena Miranda, Juan Perez, Riccardo Ronzoni, James A Irving

JCI Insight· July 2020

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Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population.
Mattia Laffranchi, Emma L K Elliston, Fabrizio Gangemi, Romina Berardelli, David A Lomas, James A Irving

PLoS One· September 2019

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Lanthanides compete with calcium for binding to cadherins and inhibit cadherin-mediated cell adhesion.
Lewis L Brayshaw, Rosanna C G Smith, Magd Badaoui, James A Irving, Stephen R Price

Metallomics· May 2019

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In Vitro Approaches for the Assessment of Serpin Polymerization.
Emma L K Elliston, David A Lomas, James A Irving

Methods Mol Biol· March 2019

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Probing the folding pathway of a consensus serpin using single tryptophan mutants.
Li Yang, James A Irving, Weiwen Dai, Marie-Isabel Aguilar, Stephen P Bottomley

Sci Rep· February 2018

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