Publications by authors named "Alexei Kisselev"

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Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia.
Tyler W Jenkins, Jacquelyn Elise Fitzgerald, Jieun Park, Addison M Wilson, Kristy L Berry, Alexei F Kisselev

Sci Rep· May 2025

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Inhibition of proteolytic and ATPase activities of the proteasome by the BTK inhibitor CGI-1746.
Olasubomi A Akintola, Mitchell B Patterson, John G Smith, George N DeMartino, Amit K Mitra, Alexei F Kisselev

iScience· November 2024

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Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2.
Ibtisam Ibtisam, Alexei F Kisselev

Elife· April 2024

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Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2.
Ibtisam Ibtisam, Alexei F Kisselev

bioRxiv· November 2023

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NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells.
Umit Aliyaskarova, Yeldar Baiken, Flore Renaud, Sophie Couve, Alexei F Kisselev

Sci Rep· March 2023

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A clinically relevant pulse treatment generates a bortezomib-resistant myeloma cell line that lacks proteasome mutations and is sensitive to Bcl-2 inhibitor venetoclax.
Sondra L Downey-Kopyscinski, Sriraja Srinivasa, Alexei F Kisselev

Sci Rep· July 2022

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Site-Specific Proteasome Inhibitors.
Alexei F Kisselev

Biomolecules· December 2021

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Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib (MLN9708) and Fulvestrant in Advanced ER+ Breast Cancer Progressing on Fulvestrant.
Gary Schwartz, Kevin Shee, Bianca Romo, Jonathan Marotti, Alexei Kisselev

Oncologist· June 2021

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Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL-AF4 fusion protein.
Tyler W Jenkins, Sondra L Downey-Kopyscinski, Jennifer L Fields, Gilbert J Rahme, William C Colley, Alexei F Kisselev

Sci Rep· May 2021

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DNA-Histone Cross-Links: Formation and Repair.
Manideep C Pachva, Alexei F Kisselev, Bakhyt T Matkarimov, Murat Saparbaev, Regina Groisman

Front Cell Dev Biol· December 2020

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Structure-Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits.
Elmer Maurits, Christian G Degeling, Alexei F Kisselev, Bogdan I Florea, Herman S Overkleeft

Chembiochem· November 2020

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Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits.
Bo-Tao Xin, Eva M Huber, Gerjan de Bruin, Wolfgang Heinemeyer, Elmer Maurits, Alexei F Kisselev

J Med Chem· February 2019

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An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors.
Sondra Downey-Kopyscinski, Ellen W Daily, Marc Gautier, Ananta Bhatt, Bogdan I Florea, Alexei F Kisselev

Blood Adv· October 2018

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Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.
Emily S Weyburne, Owen M Wilkins, Zhe Sha, David A Williams, Alexandre A Pletnev, Alexei F Kisselev

Cell Chem Biol· February 2017

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Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes.
Bo-Tao Xin, Gerjan de Bruin, Eva M Huber, Andrej Besse, Bogdan I Florea, Alexei F Kisselev

J Med Chem· August 2016

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UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.
Emilie Laure Dubois, Scott Gerber, Alexei Kisselev, Annick Harel-Bellan, Regina Groisman

Oncol Rep· May 2016

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A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities.
Gerjan de Bruin, Bo Tao Xin, Marianne Kraus, Mario van der Stelt, Gijsbert A van der Marel, Alexei F Kisselev

Angew Chem Int Ed Engl· March 2016

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The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells.
Marianne Kraus, Juergen Bader, Paul P Geurink, Emily S Weyburne, Anne C Mirabella, Alexei F Kisselev

Haematologica· October 2015

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The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells.
Johannes Kraus, Marianne Kraus, Nora Liu, Lenka Besse, Jürgen Bader, Alexei F Kisselev

Cancer Chemother Pharmacol· August 2015

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Use of proteasome inhibitors.
Sondra L Downey, Bogdan I Florea, Herman S Overkleeft, Alexei F Kisselev

Curr Protoc Immunol· April 2015

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Subunit specific inhibitors of proteasomes and their potential for immunomodulation.
Alexei F Kisselev, Marcus Groettrup

Curr Opin Chem Biol· December 2014

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Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.
Gerjan de Bruin, Eva M Huber, Bo-Tao Xin, Eva J van Rooden, Karol Al-Ayed, Alexei F Kisselev

J Med Chem· July 2014

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Cell-line-specific high background in the Proteasome-Glo assay of proteasome trypsin-like activity.
Owen M Wilkins, Sondra L Downey, Emily S Weyburne, David A Williams, Anne C Mirabella, Alexei F Kisselev

Anal Biochem· April 2014

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A novel bullet hits the proteasome.
Alexei F Kisselev

Cancer Cell· December 2013

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Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib.
Tamer B Shabaneh, Sondra L Downey, Ayrton L Goddard, Michael Screen, Marcella M Lucas, Alexei F Kisselev

PLoS One· September 2013

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