Publications by authors named "Alireza Sharafshah"

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Association and haplotype analysis of TCF7L2 gene variants with development of obesity in type 2 diabetic patients among Northern Iranians.
Saima Abbaspour, Parvaneh Keshavarz, Alireza Sharafshah

J Diabetes Metab Disord· December 2025

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A Multi-Ancestry GWAS Meta-Analysis Integrated with In-Depth Silico, Systems Biology, and Pharmacogenomics Approaches on Alzheimer's Disease Among 1,198,689 Subjects.
Alireza Sharafshah, Sajjad Rezaei

J Mol Neurosci· December 2025

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Exercise-driven modulation of glutamatergic signaling: mechanisms and clinical implications.
Candice Yu, John R Tyler, Igor Elman, Kenneth Blum, Kai Uwe Lewandrowski, Alireza Sharafshah

Neuroscience· November 2025

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Computational GWAS Meta Meta Analysis Revealing Cross Talk Between Cannabis CNR1 and DRD2 Receptors Optimizing Long-Term Outcomes for Cannabis Use Disorder (CUD) By Enhancing Dopamine Homeostasis Promoting High-Quality Cannabis Medicinals.
Kenneth Blum, Alireza Sharafshah, Jag Khalsa, Kai-Uwe Lewandrowski, Panayotis K Thanos

Res Sq· November 2025

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Correction: Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia.
Kai-Uwe Lewandrowski, Kenneth Blum, Alexander P L Lewandrowski, Panayotis K Thanos, Albert Pinhasov, Alireza Sharafshah

Front Public Health· November 2025

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Opioid-Induced Hyperalgesia and Inflammaging in the Management of Spine Pain: The Case for Genetically Directed Dopamine Homeostasis.
Kai-Uwe Lewandrowski, Rossano Kepler Alvim Fiorelli, Sergio Schmidt, Alireza Sharafshah, David Baron

Int J Spine Surg· September 2025

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Correction: Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.
Christopher Rowan, Colin Hanna, Munawwar Sajjad, Rutao Yao, Alireza Sharafshah

PLoS One· September 2025

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PGx-Based in silico Analyses Identifies the Interactive Role of Genes, Glucose Metabolism and Dopaminergic Dysfunctional Pathways with Chronic Cocaine use and Misuse.
Alireza Sharafshah, Panayotis K Thanos, Albert Pinhasov, Abdalla Bowirrat, Colin Hanna

Curr Neuropharmacol· September 2025

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Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia.
Kai-Uwe Lewandrowski, Kenneth Blum, Alexander P L Lewandrowski, Panayotis K Thanos, Albert Pinhasov, Alireza Sharafshah

Front Public Health· September 2025

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Precision Genomics: A Reality Having Universal Impact in a New Era of Psychiatry - Lessons Learned, Past and Present.
Kenneth Blum, Alireza Sharafshah, Jag Khalsa, Kai Uwe-Lewandrowski, Kavya Mohankumar

J Addict Psychiatry· August 2025

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A GWAS Meta-meta-analysis and In-depth Silico Pharmacogenomic Investigations in Identification of APOE and Other Genes Associated with Pain, Anti-inflammatory, and Immunomodulating Agents in Opioid Use Disorder (OUD) Derived from 14.91 M Subjects.
Alireza Sharafshah, Majid Motovali-Bashi, Kenneth Blum, Kai-Uwe Lewandrowski, Mark S Gold

Cell Mol Neurobiol· July 2025

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Multi-Locus Pro-Dopaminergic Restoration of Reward Brain Circuitry in Reward Deficiency Rescinds Mono-Pharmaceutical Targeting.
Kenneth Blum, Kavya Mohankumar, Debasis Bagchi, Kai Uwe Lewandrowski, Alireza Sharafshah

Neurology (ECronicon)· July 2025

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GLP-1 and Its Role in Glycogen Production: A Narrative Review.
Joseph Lotosky, Xavier Jean, Anungoo Altankhuyag, Saqib Khan, Ashley Bernotas, Alireza Sharafshah

Biomedicines· June 2025

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Exploring dopamine as the master regulator of brain circuitry and mental health genome.
Kenneth Blum, Eric R Braverman, Alireza Sharafshah, Igor Elman, Kai-Uwe Lewandrowski

Gene Protein Dis· June 2025

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A Comprehensive 4-Layered In Silico Pharmacogenomics Analysis of the Genetic Addiction Risk Severity (GARS) Test: Strong Genetic Evidence Supporting GARS as a Novel Personalized Pre-Addiction Assessment Tool in the Opioid Crisis Era.
Alireza Sharafshah, Kai-Uwe Lewandrowski, Igor Elman, David Baron, Panayotis K Thanos

Curr Pharm Biotechnol· April 2025

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Is It Scientifically Possible To 'Cure" Reward Deficiency Syndrome (RDS) Via Transplice Molecular Genetic Technology?
Kenneth Blum, Alireza Sharafshah, Kai -Uwe-Lewandowski, Albert Pinhasov, Igor Elman

Acta Sci Neurol· April 2025

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Theorizing The Role of Gama Type Endorphins in Schizophrenia and Alcoholism: Promoting Genetic Testing and Attempts at Inducing "Dopamine Homeostasis".
Kenneth Blum, Kai Uwe Lewandowski, Alireza Sharafshah, Catherine A Dennen, Albert Pinhasov

Acta Sci Neurol· April 2025

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Dopaminergic Homeostatic Therapy (DHT) as a Putative Anti-Addiction Seeking Intervention and Early Identification of Genetic Preaddiction with Genetic Addiction Risk Severity (GARS) Screening.
Kai-Uwe Lewandrowski, Abdalla Bowirrat, Albert Pinhasov, Alireza Sharafshah, Mark S Gold

Acta Sci Neurol· April 2025

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Genetic and Regulatory Mechanisms of Comorbidity of Anxiety, Depression and ADHD: A GWAS Meta-Meta-Analysis Through the Lens of a System Biological and Pharmacogenomic Perspective in 18.5 M Subjects.
Kai-Uwe Lewandrowski, Kenneth Blum, Alireza Sharafshah, Kyriaki Z Thanos, Panayotis K Thanos

J Pers Med· March 2025

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Pharmacogenomics-Based Detection of Variants Involved in Pain, Anti-inflammatory and Immunomodulating Agents Pathways by Whole Exome Sequencing and Deep Investigations Revealed Novel Chemical Carcinogenesis and Cancer Risks.
Alireza Sharafshah, Majid Motovali-Bashi, Parvaneh Keshavarz

Iran J Med Sci· February 2025

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Response to the SAMHSA Clinical Advisory: Considerations for Genetic Testing in the Assessment of Substance Use Disorder Risk.
Richard Paul Green, Kenneth Blum, Kai Uwe Lewandrowski, Mark S Gold, Alexander P L Lewandrowski, Alireza Sharafshah

Subst Abuse Rehabil· January 2025

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Theorizing that Psychedelic Assisted Therapy May Play a Role in the Treatment of Trauma-Induced Personality Disorders.
Gianni Martire, Daniel Sipple, David Baron, Mark S Gold, Kai-Uwe Lewandowski, Alireza Sharafshah

J Addict Psychiatry· November 2024

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Complex NADASE Infusions Improve Clinical Outcome in Substance Use Disorder: Descriptive Annotation in Fifty Cases.
Kenneth Blum, Thomas Mclaughlin, Kai Uwe Lewandrowski, Alireza Sharafshah, Catherine Dennen

J Addict Psychiatry· August 2024

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Solving the Global Opioid Crisis: Incorporating Genetic Addiction Risk Assessment with Personalized Dopaminergic Homeostatic Therapy and Awareness Integration Therapy.
Foojan Zeine, Nicole Jafari, David Baron, Abdalla Bowirrat, Albert Pinhasov, Alireza Sharafshah

J Addict Psychiatry· June 2024

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