Publications by authors named "Alison M Strack"

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Whitney L Petrilli, Gregory C Adam, Roman S Erdmann, Pravien Abeywickrema, Vijayalakshmi Agnani, AlisonM Strack

Cell Chem Biol· February 2021

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Whitney L Petrilli, Gregory C Adam, Roman S Erdmann, Pravien Abeywickrema, Vijayalakshmi Agnani, Alison M Strack

Cell Chem Biol· January 2020

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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis.
Alison M Strack, Ester Carballo-Jane, Sheng-Ping Wang, Jiyan Xue, Xiaoli Ping

J Lipid Res· January 2013

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Utilizing HaloTag Technology to Track the Fate of PCSK9 from Intracellular vs. Extracellular Sources.
Xi Ai, Paul Fischer, Oksana C Palyha, Douglas Wisniewski, Brian Hubbard, Alison M Strack

Curr Chem Genomics· November 2012

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Reconstituted HDL elicits marked changes in plasma lipids following single-dose injection in C57Bl/6 mice.
Zhu Chen, Edward A O'Neill, Roger D Meurer, Karen Gagen, Silvi Luell, Alison M Strack

J Cardiovasc Pharmacol Ther· September 2012

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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes.
Liwen Zhang, Timothy McCabe, Jon H Condra, Yan G Ni, Laurence B Peterson, Alison M Strack

Int J Biol Sci· July 2012

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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.
Harry R Chobanian, Yan Guo, Ping Liu, Thomas J Lanza, Marc Chioda, Alison M Strack

Bioorg Med Chem· May 2012

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Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss.
Alison M Strack, Susan Nicolich, Terry Faidley, Joana Achanfuo-Yeboah, Paul K Cunningham

Metabolism· April 2012

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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Harry R Chobanian, Yan Guo, Ping Liu, Marc Chioda, Thomas J Lanza, Alison M Strack

ACS Med Chem Lett· March 2012

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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia.
Wu Yin, Ester Carballo-Jane, David G McLaren, Vivienne H Mendoza, Karen Gagen, Alison M Strack

J Lipid Res· January 2012

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Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality.
Ping Liu, Thomas J Lanza, Marc Chioda, Carrie Jones, Harry R Chobanian, Alison M Strack

ACS Med Chem Lett· December 2011

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Validation of human ApoB and ApoAI immunoturbidity assays for non-human primate dyslipidemia and atherosclerosis research.
Zhu Chen, Alison M Strack, Alice C Stefanni, Ying Chen, Weizhen Wu

J Cardiovasc Transl Res· June 2011

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Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
Liping Wang, James A Hubert, Susan J Lee, Jie Pan, Su Qian, Alison M Strack

Bioorg Med Chem Lett· May 2011

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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Qingmei Hong, Raman K Bakshi, Brenda L Palucki, Min K Park, Zhixiong Ye, Alison M Strack

Bioorg Med Chem Lett· April 2011

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Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist.
Xiao-Ming Guan, Joseph M Metzger, Liming Yang, Kate A Raustad, Sheng-Ping Wang, Alison M Strack

J Pharmacol Exp Ther· February 2011

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Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments.
Joseph M Metzger, Karen Gagen, Kate A Raustad, Liming Yang, Amanda White, Alison M Strack

Am J Physiol Endocrinol Metab· November 2010

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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Raman K Bakshi, Qingmei Hong, Alison M Strack

Bioorg Med Chem Lett· November 2010

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Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Iyassu K Sebhat, Liangqin Guo, Alison M Strack

Bioorg Med Chem Lett· August 2010

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Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Liangqin Guo, Zhixiong Ye, Jian Liu, Shuwen He, Raman K Bakshi, Alison M Strack

Bioorg Med Chem Lett· August 2010

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Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.
Christina B Madsen-Duggan, John S Debenham, Thomas F Walsh, Lin Yan, Pei Huo, Alison M Strack

Bioorg Med Chem Lett· June 2010

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Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.
Lin Yan, Pei Huo, John S Debenham, Christina B Madsen-Duggan, Julie Lao, Alison M Strack

J Med Chem· May 2010

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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Shuwen He, Zhixiong Ye, Peter H Dobbelaar, Iyassu K Sebhat, Liangqin Guo, Alison M Strack

Bioorg Med Chem Lett· April 2010

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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
Shuwen He, Peter H Dobbelaar, Jian Liu, Tianying Jian, Iyassu K Sebhat, Alison M Strack

Bioorg Med Chem Lett· March 2010

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Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.
John S Debenham, Christina B Madsen-Duggan, Richard B Toupence, Thomas F Walsh, Junying Wang, Alison M Strack

Bioorg Med Chem Lett· February 2010

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Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Xiao-Ming Guan, Howard Chen, Peter H Dobbelaar, Yan Dong, Tung M Fong, Alison M Strack

Cell Metab· February 2010

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