Publications by authors named "Alvin Lu"

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Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury.
Shaolong Yang, Juanyu Liu, Jia Siang Khe, Alvin Jiunn Hieng Lu, Vuanghao Lim

Biomol Biomed· July 2025

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Dynamic metabolic modeling of ATP allocation during viral infection.
Alvin Lu, Ilija Dukovski, Daniel Segrè

bioRxiv· November 2024

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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Joseph M Gozgit, Melissa M Vasbinder, Ryan P Abo, Kaiko Kunii, Kristy G Kuplast-Barr, Alvin Z Lu, Luke Utley

Cancer Cell· September 2021

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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Laurie B Schenkel, Jennifer R Molina, Kerren K Swinger, Ryan Abo, Danielle J Blackwell, Alvin Z Lu

Cell Chem Biol· August 2021

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Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Tim J Wigle, Yue Ren, Jennifer R Molina, Danielle J Blackwell, Laurie B Schenkel, Alvin Z Lu

Chembiochem· June 2021

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In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.
Tim J Wigle, Danielle J Blackwell, Laurie B Schenkel, Yue Ren, W David Church, Alvin Z Lu

Cell Chem Biol· July 2020

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Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation.
Alvin Z Lu, Ryan Abo, Yue Ren, Bin Gui, Jan-Rung Mo

Biochem Pharmacol· September 2019

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Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation.
Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B Nielsen, Jun Yan, Alvin Lu

Nat Immunol· May 2019

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SERPINB1-mediated checkpoint of inflammatory caspase activation.
Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B Nielsen, Jun Yan, Alvin Lu

Nat Immunol· March 2019

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Molecular mechanism for NLRP6 inflammasome assembly and activation.
Chen Shen, Alvin Lu, Wen Jun Xie, Jianbin Ruan, Roberto Negro

Proc Natl Acad Sci U S A· February 2019

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Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.
Yang Li, Tian-Min Fu, Alvin Lu, Kristen Witt, Jianbin Ruan

Proc Natl Acad Sci U S A· October 2018

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Instant Hydrogelation Inspired by Inflammasomes.
Huaimin Wang, Zhaoqianqi Feng, Alvin Lu, Yujie Jiang, Hao Wu

Angew Chem Int Ed Engl· June 2017

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Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Tian-Min Fu, Yang Li, Alvin Lu, Zongli Li, Parimala R Vajjhala

Mol Cell· October 2016

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Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.
Alvin Lu, Yang Li, Florian I Schmidt, Qian Yin, Shuobing Chen

Nat Struct Mol Biol· May 2016

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A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
Florian I Schmidt, Alvin Lu, Jeff W Chen, Jianbin Ruan, Catherine Tang

J Exp Med· May 2016

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The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.
Parimala R Vajjhala, Alvin Lu, Darren L Brown, Siew Wai Pang, Vitaliya Sagulenko

J Biol Chem· December 2015

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Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Liman Zhang, Shuobing Chen, Jianbin Ruan, Jiayi Wu, Alexander B Tong, Alvin Lu

Science· October 2015

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Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.
Alvin Lu, Yang Li, Qian Yin, Jianbin Ruan, Xiong Yu

Cell Discov· June 2015

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Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.
Wilson Leung, Christopher D Shaffer, Laura K Reed, Sheryl T Smith, William Barshop, Erin K Luippold, Christopher E Blunden, Luke R Salbert, Rasleen K Saluja, Luis A Jimenez, Gabi Lucas, Chris Uitvlugt, Lucia Wande, Christina Paluskievicz, James M Bellush, Lena N Lupey, Maureen Corrielus, Alvin Lu, Luke J Rodriguez-Giron, Luciann Bracero-Quiñones, Luis R Colón-Cruz, Luis R Vilanova-Vélez, Young Lu Kim, Lucy Liu, Lucas A Watson

G3 (Bethesda)· March 2015

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Structural mechanisms of inflammasome assembly.
Alvin Lu, Hao Wu

FEBS J· February 2015

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Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions.
Alvin Lu, Venkataraman Kabaleeswaran, Tianmin Fu, Venkat Giri Magupalli, Hao Wu

J Mol Biol· April 2014

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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.
Alvin Lu, Venkat Giri Magupalli, Jianbin Ruan, Qian Yin, Maninjay K Atianand

Cell· March 2014

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Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.
Tony Taldone, Yanlong Kang, Hardik J Patel, Maulik R Patel, Pallav D Patel, Alvin Lu

J Med Chem· February 2014

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Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.
Qian Yin, David P Sester, Yuan Tian, Yu-Shan Hsiao, Alvin Lu

Cell Rep· July 2013

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