Publications by authors named "Alyssa R Merkel"

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Nanoparticle STING Agonist Reprograms the Bone Marrow to an Antitumor Phenotype and Protects Against Bone Destruction.
David C Florian, Natalie E Bennett, Mateusz Odziomek, Jessalyn J Baljon, Mohamed Wehbe, Alyssa R Merkel

Cancer Res Commun· February 2023

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Biphasic α2β1 Integrin Expression in Breast Cancer Metastasis to Bone.
Milene N O Moritz, Alyssa R Merkel, Ean G Feldman, Heloisa S Selistre-de-Araujo, Julie A Rhoades Sterling

Int J Mol Sci· June 2021

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EphA2 Is a Clinically Relevant Target for Breast Cancer Bone Metastatic Disease.
David B Vaught, Alyssa R Merkel, Conor C Lynch, James Edwards, Mohammed Noor Tantawy

JBMR Plus· April 2021

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3D Bone Morphology Alters Gene Expression, Motility, and Drug Responses in Bone Metastatic Tumor Cells.
Ushashi C Dadwal, Alyssa R Merkel, Jonathan M Page, Kristin A Kwakwa, Michael Kessler

Int J Mol Sci· September 2020

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Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction.
Joseph Vanderburgh, Jordan L Hill, Mukesh K Gupta, Kristin A Kwakwa, Sean K Wang, Alyssa R Merkel

ACS Nano· January 2020

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Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease.
Joseph P Vanderburgh, Kristin A Kwakwa, Thomas A Werfel, Alyssa R Merkel, Mukesh K Gupta

J Control Release· October 2019

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Platelet-derived β2M regulates monocyte inflammatory responses.
Zachary T Hilt, Daphne N Pariser, Sara K Ture, Amy Mohan, Pearl Quijada, Alyssa R Merkel

JCI Insight· March 2019

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Settable polymer/ceramic composite bone grafts stabilize weight-bearing tibial plateau slot defects and integrate with host bone in an ovine model.
Sichang Lu, Madison A P McGough, Stefanie M Shiels, Katarzyna J Zienkiewicz, Alyssa R Merkel

Biomaterials· October 2018

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Early TGF-β inhibition in mice reduces the incidence of breast cancer induced bone disease in a myeloid dependent manner.
Denise Buenrostro, Kristin A Kwakwa, Nicole E Putnam, Alyssa R Merkel, Joshua R Johnson

Bone· August 2018

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Fabrication of Trabecular Bone-Templated Tissue-Engineered Constructs by 3D Inkjet Printing.
Joseph P Vanderburgh, Shanik J Fernando, Alyssa R Merkel, Julie A Sterling, Scott A Guelcher

Adv Healthc Mater· November 2017

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Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and β2AR-Dependent Neo-Angiogenic Switch.
Patrick L Mulcrone, J Preston Campbell, Lise Clément-Demange, Ana Lia Anbinder, Alyssa R Merkel

J Bone Miner Res· July 2017

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Combined treatment with a transforming growth factor beta inhibitor (1D11) and bortezomib improves bone architecture in a mouse model of myeloma-induced bone disease.
Jeffry S Nyman, Alyssa R Merkel, Sasidhar Uppuganti, Bijaya Nayak, Barbara Rowland

Bone· October 2016

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Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow.
Rachelle W Johnson, Elizabeth C Finger, Monica M Olcina, Marta Vilalta, Todd Aguilera, Alyssa R Merkel

Nat Cell Biol· October 2016

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Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow.
Rachelle W Johnson, Elizabeth C Finger, Monica M Olcina, Marta Vilalta, Todd Aguilera, Alyssa R Merkel

Nat Cell Biol· October 2016

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Changes in the Fracture Resistance of Bone with the Progression of Type 2 Diabetes in the ZDSD Rat.
Amy Creecy, Sasidhar Uppuganti, Alyssa R Merkel, Dianne O'Neal, Alexander J Makowski

Calcif Tissue Int· September 2016

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Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II.
Jonathan M Page, Alyssa R Merkel, Nazanin S Ruppender, Ruijing Guo, Ushashi C Dadwal

Biomaterials· September 2015

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Altering adsorbed proteins or cellular gene expression in bone-metastatic cancer cells affects PTHrP and Gli2 without altering cell growth.
Jonathan M Page, Alyssa R Merkel, Nazanin S Ruppender, Ruijing Guo, Ushashi C Dadwal

Data Brief· September 2015

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Fabrication of 3D Scaffolds with Precisely Controlled Substrate Modulus and Pore Size by Templated-Fused Deposition Modeling to Direct Osteogenic Differentiation.
Ruijing Guo, Sichang Lu, Jonathan M Page, Alyssa R Merkel, Sandip Basu

Adv Healthc Mater· August 2015

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Predicting mouse vertebra strength with micro-computed tomography-derived finite element analysis.
Jeffry S Nyman, Sasidhar Uppuganti, Alexander J Makowski, Barbara J Rowland, Alyssa R Merkel

Bonekey Rep· April 2015

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Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer.
Rachelle W Johnson, Alyssa R Merkel, Jonathan M Page, Nazanin S Ruppender, Scott A Guelcher

Clin Exp Metastasis· December 2014

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Prostate cancer metastases alter bone mineral and matrix composition independent of effects on bone architecture in mice--a quantitative study using microCT and Raman spectroscopy.
Xiaohong Bi, Julie A Sterling, Alyssa R Merkel, Daniel S Perrien, Jeffry S Nyman

Bone· October 2013

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Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction.
Sabrina Danilin, Alyssa R Merkel, Joshua R Johnson, Rachelle W Johnson, James R Edwards

Oncoimmunology· December 2012

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Models of bone metastasis.
J Preston Campbell, Alyssa R Merkel, S Kathryn Masood-Campbell, Florent Elefteriou, Julie A Sterling

J Vis Exp· September 2012

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6-Thioguanine inhibition of parathyroid hormone-related protein expression is mediated by GLI2.
Rachelle W Johnson, Alyssa R Merkel, Sabrina Danilin, Mai P Nguyen, Gregory R Mundy

Anticancer Res· September 2011

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TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling.
Rachelle W Johnson, Mai P Nguyen, Susan S Padalecki, Barry G Grubbs, Alyssa R Merkel

Cancer Res· February 2011

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