Publications by authors named "Amy Crooks"

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Novel O-methylpyrimidine prodrugs of phenolic compounds bioactivated by aldehyde oxidase: Enhancing metabolic stability against first-pass conjugative metabolism in the intestine.
John P Kowalski, Brian R Baer, Samuel D Randall, Karin Brown, Amy Crooks

Drug Metab Dispos· April 2025

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Design of Potent Menin-KMT2A Interaction Inhibitors with Improved ADME Properties and Reduced hERG Affinity.
Bruno D Chapsal, Jennifer R Kimbrough, Stephanie M Bester, Alex Bergstrom, Donald S Backos, Amy L Crooks

ACS Med Chem Lett· February 2025

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Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
Quinn A Bumpers, Robert W Pipal, Anna M Benz-Weeden, James T Brewster, Adam Cook, Amy L Crooks

J Med Chem· August 2024

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Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.
Samual C Allgood, Chih-Chia Su, Amy L Crooks, Christian T Meyer, Bojun Zhou

mBio· December 2023

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Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment.
Samual C Allgood, Chih-Chia Su, Amy L Crooks, Christian T Meyer, Bojun Zhou

bioRxiv· September 2023

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Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes.
Joseph A Villanueva, Amy L Crooks, Toni A Nagy, Joaquin L J Quintana, Zachary D Dalebroux

mBio· October 2022

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A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids.
Jamie L Dombach, Joaquin L J Quintana, Toni A Nagy, Chun Wan, Amy L Crooks

PLoS Pathog· December 2020

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Clofazimine Reduces the Survival of in Macrophages and Mice.
Toni A Nagy, Amy L Crooks, Joaquin L J Quintana, Corrella S Detweiler

ACS Infect Dis· May 2020

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Autophagy Induction by a Small Molecule Inhibits Survival in Macrophages and Mice.
Toni A Nagy, Joaquin L J Quintana, Abigail L Reens, Amy L Crooks, Corrella S Detweiler

Antimicrob Agents Chemother· September 2019

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A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load.
Abigail L Reens, Amy L Crooks, Chih-Chia Su, Toni A Nagy, David L Reens

PLoS Pathog· June 2018

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Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses.
Eugenia Silva-Herzog, Erin M McDonald, Amy L Crooks, Corrella S Detweiler

PLoS One· June 2016

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