Publications by authors named "Amy E Mercer"

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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
Paul M O'Neill, Richard K Amewu, Susan A Charman, Sunil Sabbani, Nina F Gnädig, Amy E Mercer

Nat Commun· May 2017

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Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.
Ian M Copple, Amy E Mercer, James Firman, Gail Donegan, Bram Herpers

Mol Med· September 2012

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The pharmacokinetic evaluation of artemisinin drugs for the treatment of malaria in paediatric populations.
Amy E Mercer, Mariama Sarr Sallah

Expert Opin Drug Metab Toxicol· April 2011

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The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.
Amy E Mercer, Ian M Copple, James L Maggs, Paul M O'Neill, B Kevin Park

J Biol Chem· January 2011

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Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
Richard Amewu, Peter Gibbons, Amira Mukhtar, Andrew V Stachulski, Stephen A Ward, Amy E Mercer

Org Biomol Chem· May 2010

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Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.
James Chadwick, Michael Jones, Amy E Mercer, Paul A Stocks, Stephen A Ward

Bioorg Med Chem· April 2010

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Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.
Amy E Mercer, Sophie L Regan, Charlotte M Hirst, Emma E Graham, Daniel J Antoine

Toxicol Appl Pharmacol· September 2009

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Antitumour and antimalarial activity of artemisinin-acridine hybrids.
Michael Jones, Amy E Mercer, Paul A Stocks, Louise J I La Pensée, Rick Cosstick

Bioorg Med Chem Lett· April 2009

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Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.
James Chadwick, Amy E Mercer, B Kevin Park, Richard Cosstick, Paul M O'Neill

Bioorg Med Chem· February 2009

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The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials.
Amy E Mercer

Curr Opin Drug Discov Devel· January 2009

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Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Paul A Stocks, Patrick G Bray, Victoria E Barton, Mohammed Al-Helal, Michael Jones, Amy E Mercer

Angew Chem Int Ed Engl· October 2007

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Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds.
Amy E Mercer, James L Maggs, Xiao-Ming Sun, Gerald M Cohen, James Chadwick

J Biol Chem· March 2007

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Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.
J Prince Jeyadevan, Patrick G Bray, James Chadwick, Amy E Mercer, Aoife Byrne

J Med Chem· February 2004

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