Publications by authors named "Ana M Tomas"

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Π-Π stacking stabilized polymeric micelles for hydrophobic drug delivery in the treatment of leishmaniasis.
Ana G Gomes-Alves, Aida Varela-Moreira, Tânia Cruz, Margarida Duarte, Helena Castro

Int J Pharm· December 2025

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The cytosolic hyperoxidation-sensitive and -robust Leishmania peroxiredoxins cPRX1 and cPRX2 are both dispensable for parasite infectivity.
Helena Castro, Maria InĂŞs Rocha, Margarida Duarte, Jordi Vilurbina, Ana Georgina Gomes-Alves

Redox Biol· May 2024

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Structure-Activity Relationship Studies of 9-Alkylamino-1,2,3,4-tetrahydroacridines against () Promastigotes.
Carlos F M Silva, Teresa Leão, Filipa Dias, Ana M Tomás, Diana C G A Pinto

Pharmaceutics· February 2023

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Covalent Conjugation of Amphotericin B to Hyaluronic Acid: An Injectable Water-Soluble Conjugate with Reduced Toxicity and Anti-Leishmanial Potential.
Ricardo Silva-Carvalho, Teresa Leão, Francisco M Gama, Ana M Tomás

Biomacromolecules· March 2022

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type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I.
Margarida Duarte, Cleide Ferreira, Gurleen Kaur Khandpur, Tamara Flohr, Jannik Zimmermann

Proc Natl Acad Sci U S A· October 2021

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Epigallocathechin--3-Gallate Inhibits Trypanothione Reductase of , Causing Alterations in Redox Balance and Leading to Parasite Death.
Job D F Inacio, Myslene S Fonseca, Gabriel Limaverde-Sousa, Ana M Tomas, Helena Castro

Front Cell Infect Microbiol· July 2021

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Biological Evaluation and Mechanistic Studies of Quinolin-(1)-Imines as a New Chemotype against Leishmaniasis.
Ana Georgina Gomes-Alves, Margarida Duarte, Tânia Cruz, Helena Castro, Francisca Lopes

Antimicrob Agents Chemother· June 2021

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Mechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper ().
Anderson Dematei, João B Nunes, Daniel C Moreira, Jéssica A Jesus, Márcia D Laurenti

J Nat Prod· June 2021

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Enhances Migration of Macrophages via a Phosphoinositide 3-Kinase Îł-Dependent Pathway.
Maria InĂŞs Rocha, Filipa Dias, Mariana Resende, Mafalda Sousa, Margarida Duarte

ACS Infect Dis· July 2020

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Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents.
Helena Castro, Tânia Cruz, Patrícia de Aguiar Amaral, Paula da Silva Cardoso, Ahmed Alsaffar

Heliyon· March 2020

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Functional insight into the glycosomal peroxiredoxin of Leishmania.
Helena Castro, Maria InĂŞs Rocha, Ricardo Silva, Filipe Oliveira, Ana Georgina Gomes-Alves

Acta Trop· January 2020

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Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
Filipa Teixeira, Eric Tse, Helena Castro, Karl A T Makepeace, Ben A Meinen

Nat Commun· February 2019

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Development of an automated image analysis protocol for quantification of intracellular forms of Leishmania spp.
Ana G Gomes-Alves, André F Maia, Tânia Cruz, Helena Castro, Ana M Tomás

PLoS One· January 2019

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In Silico Discovery of a Substituted 6-Methoxy-quinalidine with Leishmanicidal Activity in Leishmania infantum.
Strahinja Stevanović, Andrej Perdih, Milan Senćanski, Sanja Glišić, Margarida Duarte

Molecules· March 2018

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Calcium and magnesium ions modulate the oligomeric state and function of mitochondrial 2-Cys peroxiredoxins in parasites.
Mariana A B Morais, Priscila O Giuseppe, Tatiana A C B Souza, Helena Castro, Rodrigo V Honorato, Ana M Tomas

J Biol Chem· April 2017

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Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli.
Mariela M Marani, Luis O Perez, Alyne Rodrigues de Araujo, Alexandra Plácido, Carla F Sousa

Gene· March 2017

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Ocellatin-PT antimicrobial peptides: High-resolution microscopy studies in antileishmania models and interactions with mimetic membrane systems.
Mayara Oliveira, Ana Georgina Gomes-Alves, Carla Sousa, Mariela Mirta Marani, Alexandra Plácido, Ana M Tomas

Biopolymers· December 2016

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Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.
Verónica Gómez Pérez, Raquel García-Hernandez, Victoriano Corpas-López, Ana M Tomás, Joaquina Martín-Sanchez

Int J Parasitol Drugs Drug Resist· August 2016

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Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection.
Filipe Marques, Sílvia Vale-Costa, Tânia Cruz, Joana Moreira Marques, Tânia Silva

Parasit Vectors· December 2015

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Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems.
Maria Manuela Gaspar, Susana Calado, Joana Pereira, Helena Ferronha, Ivone Correia

Nanomedicine· October 2015

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New insights into neutrophil and Leishmania infantum in vitro immune interactions.
Cláudia S Marques, Luiz Felipe D Passero, Inês Vale-Gato, Armanda Rodrigues, Olivia Roos Rodrigues

Comp Immunol Microbiol Infect Dis· June 2015

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LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites.
Sandra Carvalho, Rosa Barreira da Silva, Ali Shawki, Helena Castro, Márcia Lamy

Mol Microbiol· May 2015

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Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum.
Filipa Teixeira, Helena Castro, Tânia Cruz, Eric Tse, Philipp Koldewey

Proc Natl Acad Sci U S A· February 2015

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Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum.
André F Sousa, Ana G Gomes-Alves, Diego Benítez, Marcelo A Comini, Leopold Flohé

Free Radic Biol Med· August 2014

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The mitochondrial complex I of trypanosomatids--an overview of current knowledge.
Margarida Duarte, Ana M Tomás

J Bioenerg Biomembr· August 2014

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