Publications by authors named "Andreas Topp"

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Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization.
David F Nippa, Kenneth Atz, Yannick Stenzhorn, Alex T Müller, Andreas Tosstorff, Andreas Topp

Nat Commun· November 2025

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Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.
Martin R Edelmann, Luca C Gobbi, Svenja Schmalzbauer, Jennifer Beck, Mathias C Müller, Andreas Topp

ACS Chem Neurosci· October 2025

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CellEKT: A Robust Chemical Proteomics Workflow to Profile Cellular Target Engagement of Kinase Inhibitors.
Joel Rüegger, Berend Gagestein, Antonius P A Janssen, Alexandra Valeanu, Alger Lazo Mori, Andreas Topp

Mol Cell Proteomics· June 2025

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Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells.
Thais Gazzi, Benjamin Brennecke, Valentas Olikauskas, Remo Hochstrasser, Haiyan Wang, Andreas Topp

Chembiochem· March 2025

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Exploration of (R)-[C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates.
Yingfang He, MingQiang Zheng, Jiwei Gu, Lisa Reichert, Johannes Trimborn, Andreas Topp

Eur J Nucl Med Mol Imaging· March 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase.
Axel Hentsch, Mónica Guberman, Silke Radetzki, Sofia Kaushik, Mirjam Huizenga, Andreas Topp

Angew Chem Int Ed Engl· March 2025

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Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research.
Axel Hentsch, Mónica Guberman, Silke Radetzki, Sofia Kaushik, Mirjam Huizenga, Andreas Topp

J Am Chem Soc· March 2025

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Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.
Maude Giroud, Bernd Kuhn, Sandra Steiner, Paul Westwood, Mateusz Mendel, Andreas Topp

J Med Chem· March 2025

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Structure-Guided Discovery of -Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.
Bernd Kuhn, Martin Ritter, Benoit Hornsperger, Charles Bell, Buelent Kocer, Andreas Topp

J Med Chem· October 2024

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Identification of ()-[F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development.
Yingfang He, Stefanie D Krämer, Uwe Grether, Matthias B Wittwer, Ludovic Collin, Andreas Topp

J Nucl Med· February 2024

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Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging.
Yingfang He, Matthias Schild, Uwe Grether, Jörg Benz, Lea Leibrock, Andreas Topp

J Med Chem· February 2022

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Band Engineering of Dirac Semimetals Using Charge Density Waves.
Shiming Lei, Samuel M L Teicher, Andreas Topp, Kehan Cai, Jingjing Lin

Adv Mater· July 2021

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Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.
Joerg Benz, Arne C Rufer, Sylwia Huber, Andreas Ehler, Melanie Hug, Andreas Topp

Angew Chem Int Ed Engl· March 2021

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The Role of Delocalized Chemical Bonding in Square-Net-Based Topological Semimetals.
Sebastian Klemenz, Aurland K Hay, Samuel M L Teicher, Andreas Topp, Jennifer Cano

J Am Chem Soc· April 2020

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High mobility in a van der Waals layered antiferromagnetic metal.
Shiming Lei, Jingjing Lin, Yanyu Jia, Mason Gray, Andreas Topp

Sci Adv· February 2020

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Single-Crystal Growth and Characterization of the Chalcopyrite Semiconductor CuInTe for Photoelectrochemical Solar Fuel Production.
Jessica J Frick, Andreas Topp, Sebastian Klemenz, Maxim Krivenkov, Andrei Varykhalov

J Phys Chem Lett· December 2018

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Tunable Weyl and Dirac states in the nonsymmorphic compound CeSbTe.
Leslie M Schoop, Andreas Topp, Judith Lippmann, Fabio Orlandi, Lukas Müchler

Sci Adv· February 2018

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HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.
Alvaro Cortes Cabrera, Esther Melo, Doris Roth, Andreas Topp, Frederic Delobel

Sci Rep· November 2017

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Dirac cone protected by non-symmorphic symmetry and three-dimensional Dirac line node in ZrSiS.
Leslie M Schoop, Mazhar N Ali, Carola Straßer, Andreas Topp, Andrei Varykhalov

Nat Commun· May 2016

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Effect of compounds affecting ABCA1 expression and CETP activity on the HDL pathway involved in intestinal absorption of lutein and zeaxanthin.
Eric J Niesor, Evelyne Chaput, Jean-Luc Mary, Andreas Staempfli, Andreas Topp

Lipids· December 2014

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