Publications by authors named "Matthias B Wittwer"

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Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists.
Jara Bouma, Elisa J M de Koning, Cas van der Horst, Sanjay Sunil Kumar, Barry J W van den Berg, Matthias B Wittwer

Pharmacol Res· December 2025

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Translational molecular imaging and drug development in multiple sclerosis.
Daniel Tay, Hazem Ahmed, Alyaa Dawoud, Mohamed Salam, Luca Gobbi, Matthias B Wittwer

Theranostics· December 2025

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Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization.
David F Nippa, Kenneth Atz, Yannick Stenzhorn, Alex T Müller, Andreas Tosstorff, Matthias B Wittwer

Nat Commun· November 2025

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Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.
Martin R Edelmann, Luca C Gobbi, Svenja Schmalzbauer, Jennifer Beck, Mathias C Müller, Matthias B Wittwer

ACS Chem Neurosci· October 2025

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Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB receptor activation in experimental ALS in male mice.
Marta Gómez-Almería, Claudia Gonzalo-Consuegra, Carmen Rodríguez-Cueto, María Cabañas-Cotillas, Alberto Jiménez-Amor, Matthias B Wittwer

Cell Commun Signal· October 2025

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Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells.
Thais Gazzi, Benjamin Brennecke, Valentas Olikauskas, Remo Hochstrasser, Haiyan Wang, Matthias B Wittwer

Chembiochem· March 2025

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Exploration of (R)-[C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates.
Yingfang He, MingQiang Zheng, Jiwei Gu, Lisa Reichert, Johannes Trimborn, Matthias Beat Wittwer

Eur J Nucl Med Mol Imaging· March 2025

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Radiosynthesis and evaluation of novel F labeled PET ligands for imaging monoacylglycerol lipase.
Yinlong Li, Wakana Mori, Ahmad Chaudhary, Chunyu Zhao, Tomoteru Yamasaki, Matthias B Wittwer

Eur J Med Chem· March 2025

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A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase.
Axel Hentsch, Mónica Guberman, Silke Radetzki, Sofia Kaushik, Mirjam Huizenga, Matthias B Wittwer

Angew Chem Int Ed Engl· March 2025

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Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.
Maude Giroud, Bernd Kuhn, Sandra Steiner, Paul Westwood, Mateusz Mendel, Matthias Beat Wittwer

J Med Chem· March 2025

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Finding a needle in the haystack: ADME and pharmacokinetics/pharmacodynamics characterization and optimization toward orally available bifunctional protein degraders.
Giulia Apprato, Giulia Caron, Gauri Deshmukh, Diego Garcia-Jimenez, Robin Thomas Ulrich Haid, Matthias Beat Wittwer

Expert Opin Drug Discov· February 2025

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A novel application of hydrophilic interaction liquid chromatography for the identification of compounds with intramolecular hydrogen bonds.
Alessandra Pugliano, Bernd Kuhn, Nenad Manevski, Björn Wagner, Matthias Beat Wittwer

J Pharm Biomed Anal· January 2025

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Structure-Guided Discovery of -Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.
Bernd Kuhn, Martin Ritter, Benoit Hornsperger, Charles Bell, Buelent Kocer, Matthias Beat Wittwer

J Med Chem· October 2024

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Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.
Johannes Aebi, Kenneth Atz, Simon M Ametamey, Jörg Benz, Julie Blaising, Matthias B Wittwer

Chimia (Aarau)· August 2024

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Involvement of CB and CB receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice.
Claudia Gonzalo-Consuegra, Irene Santos-García, Laura García-Toscano, Raquel Martín-Baquero, Carmen Rodríguez-Cueto, Matthias B Wittwer

Biomed Pharmacother· May 2024

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Identification of ()-[F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development.
Yingfang He, Stefanie D Krämer, Uwe Grether, Matthias B Wittwer, Ludovic Collin

J Nucl Med· February 2024

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A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.
Ming Jiang, Mirjam C W Huizenga, Jonah L Wirt, Janos Paloczi, Avand Amedi, Matthias B Wittwer

Nat Commun· December 2023

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Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain.
Yingfang He, Uwe Grether, Marco F Taddio, Carla Meier, Claudia Keller, Matthias B Wittwer

Eur J Med Chem· December 2022

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Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.
Maciej J Zamek-Gliszczynski, Vishal Sangha, Hong Shen, Bo Feng, Matthias B Wittwer

Clin Pharmacol Ther· September 2022

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Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold.
Yingfang He, Luca C Gobbi, Adrienne Müller Herde, Didier Rombach, Martin Ritter, Matthias B Wittwer

Nucl Med Biol· June 2022

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Targeted protein degraders: a call for collective action to advance safety assessment.
Lyn H Jones, Constance A Mitchell, Lise Loberg, Mira Pavkovic, Mohan Rao, Matthias B Wittwer

Nat Rev Drug Discov· June 2022

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Considerations and recommendations for assessment of plasma protein binding and drug-drug interactions for siRNA therapeutics.
Sara C Humphreys, John A Davis, Sajida Iqbal, Amin Kamel, Kenneth Kulmatycki, Matthias B Wittwer

Nucleic Acids Res· June 2022

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Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction.
Kenichi Umehara, Carina Cantrill, Matthias Beat Wittwer, Elisa Di Lenarda, Florian Klammers

Drug Metab Dispos· October 2020

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Fundamental aspects of DMPK optimization of targeted protein degraders.
Carina Cantrill, Prasoon Chaturvedi, Caroline Rynn, Jeannine Petrig Schaffland, Isabelle Walter, Matthias B Wittwer

Drug Discov Today· June 2020

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Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.
Maciej J Zamek-Gliszczynski, Mitchell E Taub, Paresh P Chothe, Xiaoyan Chu, Kathleen M Giacomini, Matthias B Wittwer

Clin Pharmacol Ther· November 2018

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