Publications by authors named "Isabelle Walter"

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Prediction of hepatic metabolic clearance in rats and dogs using long-term cocultured hepatocytes.
Kenichi Umehara, Florian Klammers, Isabelle Walter, Tanvi Naik, Victor Dudal

Drug Metab Dispos· April 2025

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Combined Fainting and Psychogenic Non-epileptic Seizures as Significant Therapy Hurdles in Blood-Injury-Injection Phobia: A Mini-Review and Case Report.
Iven-Alex von Mücke-Heim, Isabelle Walter, Sandra Nischwitz, Angelika Erhardt

Front Psychiatry· July 2022

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Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes.
Florian Klammers, Andreas Goetschi, Aynur Ekiciler, Isabelle Walter, Neil Parrott

Drug Metab Dispos· May 2022

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Correction to: In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes.
Luca Docci, Florian Klammers, Aynur Ekiciler, Birgit Molitor, Kenichi Umehara, Isabelle Walter

AAPS J· November 2020

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In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes.
Luca Docci, Florian Klammers, Aynur Ekiciler, Birgit Molitor, Kenichi Umehara, Isabelle Walter

AAPS J· October 2020

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Fundamental aspects of DMPK optimization of targeted protein degraders.
Carina Cantrill, Prasoon Chaturvedi, Caroline Rynn, Jeannine Petrig Schaffland, Isabelle Walter

Drug Discov Today· June 2020

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A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria.
Anders N Kristoffersson, Caterina Bissantz, Rusudan Okujava, Andreas Haldimann, Isabelle Walter

J Antimicrob Chemother· February 2020

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Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.
Nicole A Kratochwil, Miriam Triyatni, Martina B Mueller, Florian Klammers, Brian Leonard, Isabelle Walter

J Pharmacol Exp Ther· May 2018

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Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.
Nicole A Kratochwil, Christophe Meille, Stephen Fowler, Florian Klammers, Aynur Ekiciler, Isabelle Walter

AAPS J· March 2017

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Targeted γ-Secretase Inhibition To Control the Notch Pathway in Renal Diseases.
Lucienne Juillerat-Jeanneret, Alexander Flohr, Manfred Schneider, Isabelle Walter, Jean-Christophe Wyss

J Med Chem· October 2015

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Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis.
Stephan Benay, Christophe Meille, Stefan Kustermann, Isabelle Walter, Antje Walz

J Pharmacokinet Pharmacodyn· June 2015

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Calibration of in vitro multidrug resistance protein 1 substrate and inhibition assays as a basis to support the prediction of clinically relevant interactions in vivo.
Agnès Poirier, Anne-Christine Cascais, Urs Bader, Renée Portmann, Marie-Elise Brun, Isabelle Walter

Drug Metab Dispos· September 2014

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The need for human breast cancer resistance protein substrate and inhibition evaluation in drug discovery and development: why, when, and how?
Agnès Poirier, Renée Portmann, Anne-Christine Cascais, Urs Bader, Isabelle Walter

Drug Metab Dispos· September 2014

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In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam.
Roberto C Bravo González, Jörg Huwyler, Franziska Boess, Isabelle Walter, Beate Bittner

Biopharm Drug Dispos· January 2004

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Impact of Solutol HS 15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male Wistar rats.
Beate Bittner, Roberto Carlos Bravo González, Isabelle Walter, Martin Kapps, Jörg Huwyler

Biopharm Drug Dispos· May 2003

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Improved oral bioavailability of cyclosporin A in male Wistar rats. Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension.
Roberto Carlos Bravo González, Jörg Huwyler, Isabelle Walter, Richard Mountfield, Beate Bittner

Int J Pharm· October 2002

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