Publications by authors named "Manfred Schneider"

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Safety, Tolerability, Pharmacokinetics, and Brain Target Occupancy of the OGA Inhibitor ASN90 in Healthy Participants.
Rolf Pokorny, J Michael Ryan, Khalid Abd-Elaziz, Frans van den Berg, Eugenii Rabiner, Manfred Schneider

Mov Disord· November 2025

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Structure-Guided Discovery of -Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.
Bernd Kuhn, Martin Ritter, Benoit Hornsperger, Charles Bell, Buelent Kocer, Manfred Schneider

J Med Chem· October 2024

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Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
Marc P Hübner, Coralie Martin, Sabine Specht, Marianne Koschel, Bettina Dubben, Manfred Schneider

PLoS Negl Trop Dis· July 2020

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Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury.
Jean-Christophe Wyss, Rajesh Kumar, Josip Mikulic, Manfred Schneider, Jean-Luc Mary

Front Pharmacol· November 2019

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Low Prevalence of Isolated Growth Hormone Deficiency in Patients After Brain Injury: Results From a Phase II Pilot Study.
Miriam Leonhardt, Anna Kopczak, Barbara Schäpers, Janina Limbrock, Philipp G Sämann, Harald J Schneider, Manfred Schneider

Front Endocrinol (Lausanne)· December 2018

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Targeted γ-secretase inhibition of Notch signaling activation in acute renal injury.
Jean-Christophe Wyss, Rajesh Kumar, Josip Mikulic, Manfred Schneider, Johannes D Aebi

Am J Physiol Renal Physiol· May 2018

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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
Stefano Crosignani, Patrick Bingham, Pauline Bottemanne, Hélène Cannelle, Sandra Cauwenberghs, Manfred Schneider

J Med Chem· December 2017

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ADX71943 and ADX71441, novel positive allosteric modulators of the GABA receptor with distinct central/peripheral profiles, show efficacy in the monosodium iodoacetate model of chronic osteoarthritis pain in the rat.
Mikhail Kalinichev, Tansy Donovan-Rodriguez, Françoise Girard, Hasnaá Haddouk, Isabelle Royer-Urios, Manfred Schneider

Eur J Pharmacol· January 2017

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Neuroendocrine Disturbances One to Five or More Years after Traumatic Brain Injury and Aneurysmal Subarachnoid Hemorrhage: Data from the German Database on Hypopituitarism.
Carmen Krewer, Manfred Schneider, Harald Jörn Schneider, Ilonka Kreitschmann-Andermahr, Michael Buchfelder

J Neurotrauma· August 2016

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Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.
Claudia Volpi, Giada Mondanelli, Maria T Pallotta, Carmine Vacca, Alberta Iacono, Manfred Schneider

Neuropharmacology· March 2016

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The Development of Neuroendocrine Disturbances over Time: Longitudinal Findings in Patients after Traumatic Brain Injury and Subarachnoid Hemorrhage.
Anna Kopczak, Carmen Krewer, Manfred Schneider, Ilonka Kreitschmann-Andermahr, Harald Jörn Schneider

Int J Mol Sci· December 2015

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Targeted γ-Secretase Inhibition To Control the Notch Pathway in Renal Diseases.
Lucienne Juillerat-Jeanneret, Alexander Flohr, Manfred Schneider, Isabelle Walter, Jean-Christophe Wyss

J Med Chem· October 2015

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Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.
Lothar Lindemann, Richard H Porter, Sebastian H Scharf, Basil Kuennecke, Andreas Bruns, Manfred Schneider

J Pharmacol Exp Ther· April 2015

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Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy.
Anna Quattropani, Wolfgang H B Sauer, Stefano Crosignani, Jerome Dorbais, Patrick Gerber, Manfred Schneider

ChemMedChem· April 2015

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Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira, Nadia Bitter-Stoll, Manfred Schneider

J Med Chem· February 2015

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Screening for hypopituitarism in 509 patients with traumatic brain injury or subarachnoid hemorrhage.
Anna Kopczak, Ingo Kilimann, Friedrich von Rosen, Carmen Krewer, Harald Jörn Schneider, Manfred Schneider

J Neurotrauma· January 2014

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The influence of gender on the injury severity, course and outcome of traumatic brain injury.
Caroline Renner, Horst Hummelsheim, Anna Kopczak, Diethard Steube, Harald J Schneider, Manfred Schneider

Brain Inj· January 2013

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Beyond herniation.
Andreas Bender, Jürgen Herzog, Manfred Schneider, Jennifer Linn, Tobias Winkler

Clin Neurol Neurosurg· October 2012

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Amphiphiles based on D-glucose: efficient low molecular weight gelators.
Sukhendu Nandi, Hans-Josef Altenbach, Bernd Jakob, Karsten Lange, Rachid Ihizane, Manfred P Schneider

Org Lett· August 2012

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Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression.
Brice Campo, Mikhail Kalinichev, Nathalie Lambeng, M El Yacoubi, Isabelle Royer-Urios, Manfred Schneider

J Neurogenet· December 2011

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Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.
Stefano Crosignani, Adeline Prêtre, Catherine Jorand-Lebrun, Gaële Fraboulet, Jeyaprakashnarayanan Seenisamy, Manfred Schneider

J Med Chem· October 2011

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Structured assessment of hypopituitarism after traumatic brain injury and aneurysmal subarachnoid hemorrhage in 1242 patients: the German interdisciplinary database.
Harald J Schneider, Manfred Schneider, Ilonka Kreitschmann-Andermahr, Ulrich Tuschy, Henri Wallaschofski

J Neurotrauma· September 2011

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A novel class of organo- (hydro-) gelators based on ascorbic acid.
Sukhendu Nandi, Hans-Josef Altenbach, Bernd Jakob, Karsten Lange, Rachid Ihizane, Manfred P Schneider

Org Lett· April 2011

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Anterior pituitary hormone abnormalities following traumatic brain injury.
Manfred Schneider, Harald Jörn Schneider, Günter Karl Stalla

J Neurotrauma· September 2005

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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis.
Thomas A Kerr, Shigeru Saeki, Manfred Schneider, Karen Schaefer, Sara Berdy

Dev Cell· June 2002

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