Publications by authors named "Neil Parrott"

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Physiologically-Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges.
James W T Yates, Michael Zientek, Kunal S Taskar, Wen Lin, Tycho Heimbach, Neil Parrott

CPT Pharmacometrics Syst Pharmacol· November 2025

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Prospective DDI Risk Assessment of Vicasinabin with PBPK Modeling by Integrating In Vitro Data.
Kenichi Umehara, Neil Parrott, Andreas Günther, Katrijn Bogman

Clin Pharmacol Ther· August 2025

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Optimization of In Vitro CYP3A4 TDI Assay Conditions and Use of Derived Parameters for Clinical DDI Risk Assessment Using Static and Dynamic Models.
Alessandra Pugliano, Aynur Ekiciler, Lena Preiss, Neil John Parrott, Pieter Annaert

AAPS J· August 2025

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Middle-Out Physiologically Based Pharmacokinetic Modeling to Support Pediatric Dosing Recommendation for Alectinib.
Tamara van Donge, Elena Guerini, Amaury O'Jeanson, Neil Parrott, Clare Devlin

CPT Pharmacometrics Syst Pharmacol· June 2025

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CYP1A2 contributes to the metabolism of mefloquine: Exploration using in vitro metabolism and physiologically-based pharmacokinetic modelling.
Cleavon K Cloete, Preshendren Govender, Nicholas Njuguna, Neil J Parrott, Kenichi Umehara

Drug Metab Dispos· April 2025

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Prediction of hepatic metabolic clearance in rats and dogs using long-term cocultured hepatocytes.
Kenichi Umehara, Florian Klammers, Isabelle Walter, Tanvi Naik, Victor Dudal, Neil Parrott

Drug Metab Dispos· April 2025

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Clinical Exploration and Physiologically Based Modelling of the Impact of Hepatic Impairment on Entrectinib Pharmacokinetics.
Agustos C Ozbey, Georgina Meneses-Lorente, Brian Simmons, Sam McCallum, Pieter Annaert, Neil Parrott

Clin Pharmacokinet· March 2025

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Embracing the future of medicine with virtual patients.
Ken Wang, Neil John Parrott, Thierry Lavé

Drug Discov Today· March 2025

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Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective.
Micaela B Reddy, Tamara D Cabalu, Loeckie de Zwart, Diane Ramsden, Martin E Dowty, Neil Parrott

Clin Pharmacol Ther· February 2025

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Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics.
Salma M Bahnasawy, Neil J Parrott, Matthias Gijsen, Isabel Spriet, Lena E Friberg

Int J Antimicrob Agents· December 2024

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Investigating the effect of whey and casein proteins on drug solubility from a paediatric drug absorption perspective.
Matthias Van der Veken, Joachim Brouwers, Neil Parrott, Patrick Augustijns, Cordula Stillhart

Int J Pharm X· December 2024

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PBPK Modeling of Entrectinib and Its Active Metabolite to Derive Dose Adjustments in Pediatric Populations Co-Administered with CYP3A4 Inhibitors.
Kenichi Umehara, Neil Parrott, Emilie Schindler, Valentin Legras, Georgina Meneses-Lorente

Clin Pharmacol Ther· October 2024

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Oral Absorption from Surfactant-Based Drug Formulations: The Impact of Molecularly Dissolved Drug on Bioavailability.
Florentin Lukas Holzem, Neil Parrott, Jeannine Petrig Schaffland, Martin Brandl, Annette Bauer-Brandl

J Pharm Sci· October 2024

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Food Effect in Pediatric Populations: Current Practice, Challenges, and Future Potential for Use of Physiologically Based Biopharmaceutics Modeling.
Neil Parrott

J Clin Pharmacol· August 2024

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Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4-A Case Study with Midazolam.
Agustos C Ozbey, Janneke Keemink, Bjoern Wagner, Alessandra Pugliano, Stephan Krähenbühl, Neil Parrott

Drug Metab Dispos· June 2024

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Another string to your bow: machine learning prediction of the pharmacokinetic properties of small molecules.
Davide Bassani, Neil John Parrott, Nenad Manevski, Jitao David Zhang

Expert Opin Drug Discov· June 2024

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In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design.
Nicoló Milani, Neil Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz

CPT Pharmacometrics Syst Pharmacol· April 2024

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Mechanistic Modeling of In Vitro Biopharmaceutic Data for a Weak Acid Drug: A Pathway Towards Deriving Fundamental Parameters for Physiologically Based Biopharmaceutic Modeling.
Venkata Krishna Kowthavarapu, Nitin Bharat Charbe, Churni Gupta, Tatiana Iakovleva, Cordula Stillhart, Neil John Parrott

AAPS J· April 2024

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Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL-6 levels following administration of the T-cell bispecific engager glofitamab.
Nassim Djebli, Neil Parrott, Felix Jaminion, Amaury O'Jeanson, Elena Guerini

CPT Pharmacometrics Syst Pharmacol· March 2024

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Development and application of neonatal physiology-based pharmacokinetic models of amikacin and fosfomycin to assess pharmacodynamic target attainment.
Christopher A Darlow, Neil Parrott, Richard W Peck, William Hope

CPT Pharmacometrics Syst Pharmacol· March 2024

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A Machine Learning Framework to Improve Rat Clearance Predictions and Inform Physiologically Based Pharmacokinetic Modeling.
Andrea Andrews-Morger, Michael Reutlinger, Neil Parrott, Andrés Olivares-Morales

Mol Pharm· October 2023

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PBPK Modelling for Drugs Cleared by Non-CYP Enzymes: State-of-the-Art and Future Perspectives.
Agustos C Ozbey, Stephen Fowler, Karen Leys, Pieter Annaert, Kenichi Umehara, Neil Parrott

Drug Metab Dispos· October 2023

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Correction: Van der Veken et al. Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study. 2022, , 1935.
Matthias Van der Veken, Michael Aertsen, Joachim Brouwers, Cordula Stillhart, Neil Parrott

Pharmaceutics· September 2023

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The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis.
Urs Duthaler, Fabio Bachmann, Agustos C Ozbey, Kenichi Umehara, Neil Parrott

Clin Pharmacokinet· August 2023

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Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding.
Matthias Van der Veken, Joachim Brouwers, Agustos Cetin Ozbey, Kenichi Umehara, Cordula Stillhart, Neil John Parrott

Pharmaceutics· August 2023

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