Publications by authors named "Tamara D Cabalu"

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Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective.
Micaela B Reddy, Tamara D Cabalu, Loeckie de Zwart, Diane Ramsden, Martin E Dowty

Clin Pharmacol Ther· February 2025

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Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat : From Screening Impurity to Efficacy.
Jason W Skudlarek, Andrew J Cooke, Helen J Mitchell, Kerim Babaoglu, Anthony W Shaw, Tamara D Cabalu

J Med Chem· September 2024

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Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.
Nadine Alvarez, Gregory C Adam, John A Howe, Vijeta Sharma, Matthew D Zimmerman, Tamara D Cabalu

Viruses· July 2024

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Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.
Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen, Liudmila Dzhekieva, Tamara D Cabalu

Nat Microbiol· May 2024

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Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
Valerie W Shurtleff, Mark E Layton, Craig A Parish, James J Perkins, John D Schreier, Tamara D Cabalu

J Med Chem· March 2024

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Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors.
Gregori J Morriello, Michael P Dwyer, Yili Chen, Anthony T Ginetti, Shimin Xu, Tamara D Cabalu

Bioorg Med Chem Lett· July 2021

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Physiologically Based Pharmacokinetic Modeling of Doravirine and Its Major Metabolite to Support Dose Adjustment With Rifabutin.
Ka Lai Yee, Tamara D Cabalu, Yuhsin Kuo, Kerry L Fillgrove, Yang Liu

J Clin Pharmacol· March 2021

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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.
James J Monroe, Keith Q Tanis, Alexei A Podtelezhnikov, Truyen Nguyen, Sam V Machotka, Tamara D Cabalu

Toxicol Sci· September 2020

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Recommendations for the Design of Clinical Drug-Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically-Based Pharmacokinetic Model.
Yuan Chen, Tamara D Cabalu, Ernesto Callegari, Heidi Einolf, Lichuan Liu

CPT Pharmacometrics Syst Pharmacol· September 2019

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The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Ashley B Forster, Pravien Abeywickrema, Jaime Bunda, Christopher D Cox, Tamara D Cabalu

Bioorg Med Chem Lett· December 2017

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Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors.
Danielle M Hurzy, Darrell A Henze, Tamara D Cabalu, Kartik Narayan, Amanda Heller

Bioorg Med Chem Lett· June 2017

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Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
Jason W Skudlarek, Christina N DiMarco, Kerim Babaoglu, Anthony J Roecker, Joseph G Bruno, Tamara D Cabalu

Bioorg Med Chem Lett· March 2017

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Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology.
Craig A Stump, Andrew J Cooke, Joseph Bruno, Tamara D Cabalu, Anthony L Gotter

Bioorg Med Chem Lett· December 2016

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Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Anthony J Roecker, Swati P Mercer, Jeffrey M Bergman, Kevin F Gilbert, Scott D Kuduk, Tamara D Cabalu

Bioorg Med Chem Lett· November 2015

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Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Scott D Kuduk, Jason W Skudlarek, Christina N DiMarco, Joseph G Bruno, Mark H Pausch, Tamara D Cabalu

Bioorg Med Chem Lett· June 2015

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Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Izzat T Raheem, Michael J Breslin, Joseph Bruno, Tamara D Cabalu, Andrew Cooke

Bioorg Med Chem Lett· February 2015

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Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Thomas S Reger, M Christa Mattern, Swati P Mercer, Jeffrey M Bergman, Tamara D Cabalu

Bioorg Med Chem Lett· October 2014

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Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.
Anthony J Roecker, Swati P Mercer, C Meacham Harrell, Susan L Garson, Steven V Fox, Tamara D Cabalu

Bioorg Med Chem Lett· May 2014

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Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.
Scott D Kuduk, Jason W Skudlarek, Christina N Di Marco, Joseph G Bruno, Mark A Pausch, Tamara D Cabalu

Bioorg Med Chem Lett· April 2014

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Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Swati P Mercer, John D Schreier, Christopher D Cox, Mark E Fraley, Tamara D Cabalu

ChemMedChem· February 2014

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Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Swati P Mercer, Anthony J Roecker, Susan Garson, Duane R Reiss, C Meacham Harrell, Tamara D Cabalu

Bioorg Med Chem Lett· December 2013

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Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Paul J Coleman, John D Schreier, Christopher D Cox, Michael J Breslin, David B Whitman, Tamara D Cabalu

ChemMedChem· March 2012

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Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
Christopher D Cox, Michael J Breslin, David B Whitman, John D Schreier, Georgia B McGaughey, Tamara D Cabalu

J Med Chem· July 2010

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