Publications by authors named "Scott D Kuduk"

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Intramolecular Ring Opening of Azetidines under Transition Metal-Free Conditions.
Lindsey G DeRatt, Colleen E Keohane, Zachary W Boyer, Claudia Hernandez Brito, Henry Shavel, Scott D Kuduk

J Org Chem· September 2025

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Identification of isoquinolinone DHODH inhibitor isosteres.
Lindsey G DeRatt, Zhuming Zhang, E Christine Pietsch, Justin Cisar, Aihua Wang, Scott D Kuduk

Bioorg Med Chem Lett· November 2024

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Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
Lindsey G DeRatt, Zhuming Zhang, Christine Pietsch, Justin S Cisar, Xiaochun Zhang, Scott D Kuduk

J Med Chem· July 2024

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Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
Lindsey G DeRatt, E Christine Pietsch, Justin S Cisar, Edgar Jacoby, Faraz Kazmi, Scott D Kuduk

ACS Med Chem Lett· March 2024

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Di-fluoro azepane HBV capsid assembly modulators.
Lindsey G DeRatt, Bart Stoops, Paul Shaffer, Angela M Lam, Christine Espiritu, Scott D Kuduk

Bioorg Med Chem Lett· August 2023

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Diazepinone HBV capsid assembly modulators.
Scott D Kuduk, Lindsey G DeRatt, Bart Stoops, Paul Shaffer, Angela M Lam

Bioorg Med Chem Lett· September 2022

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-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
Justin S Cisar, Christine Pietsch, Lindsey G DeRatt, Edgar Jacoby, Faraz Kazmi, Scott D Kuduk

J Med Chem· August 2022

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Tandem Amination/Oxetane Ring Opening toward Benzomorpholines.
Lindsey G DeRatt, Chao-Yuan Wang, Scott D Kuduk

J Org Chem· December 2021

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Oxadiazepinone HBV capsid assembly modulators.
Scott D Kuduk, Bart Stoops, Angela M Lam, Christine Espiritu, Robert Vogel

Bioorg Med Chem Lett· November 2021

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Identification of a new class of HBV capsid assembly modulator.
Scott D Kuduk, Bart Stoops, Richard Alexander, Angela M Lam, Christine Espiritu

Bioorg Med Chem Lett· May 2021

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A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
Lindsey G DeRatt, E Christine Pietsch, Alexandra Tanner, Paul Shaffer, Edgar Jacoby, Scott D Kuduk

Bioorg Med Chem Lett· November 2020

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Synthesis of 4-Alkylated Isocoumarins via Pd-Catalyzed α-Arylation Reaction.
Shane Plunkett, Lindsey G DeRatt, Scott D Kuduk, Jaume Balsells

Org Lett· October 2020

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450s nder striction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals.
George D Hartman, Scott D Kuduk, Christine Espiritu, Angela M Lam

ACS Med Chem Lett· October 2020

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Tandem Suzuki Coupling/Intramolecular Oxetane Ring Opening to Form Polycyclic Ring Systems.
Lindsey G DeRatt, Edward C Lawson, Kiran Kumar, Soyon S Hwang, Renee L DesJarlais, Scott D Kuduk

Org Lett· August 2020

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Mild Intramolecular Ring Opening of Oxetanes.
Lindsey G DeRatt, Edward C Lawson, Chao-Yuan Wang, Scott D Kuduk

Org Lett· December 2019

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SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.
Scott D Kuduk, Angela M Lam, Christine Espiritu, Robert Vogel, Vincent Lau

Bioorg Med Chem Lett· August 2019

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Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.
Angela M Lam, Christine Espiritu, Robert Vogel, Suping Ren, Vincent Lau, Scott D Kuduk

Antimicrob Agents Chemother· January 2019

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MK-7622: A First-in-Class M Positive Allosteric Modulator Development Candidate.
Douglas C Beshore, Christina N Di Marco, Ronald K Chang, Thomas J Greshock, Lei Ma, Scott D Kuduk

ACS Med Chem Lett· July 2018

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Preclinical to Human Translational Pharmacology of the Novel M Positive Allosteric Modulator MK-7622.
Jason M Uslaner, Scott D Kuduk, Marion Wittmann, Henry S Lange, Steve V Fox

J Pharmacol Exp Ther· June 2018

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Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
Jason W Skudlarek, Christina N DiMarco, Kerim Babaoglu, Anthony J Roecker, Joseph G Bruno, Scott D Kuduk

Bioorg Med Chem Lett· March 2017

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Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology.
Craig A Stump, Andrew J Cooke, Joseph Bruno, Tamara D Cabalu, Anthony L Gotter, Scott D Kuduk

Bioorg Med Chem Lett· December 2016

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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys.
Pamela L Tannenbaum, Spencer J Tye, Joanne Stevens, Anthony L Gotter, Steven V Fox, Scott D Kuduk

Sleep· March 2016

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Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.
Terrence McDonald, Hongyu A Liang, Raul Sanoja, Anthony L Gotter, Scott D Kuduk

J Neurogenet· March 2016

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The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys.
Henry S Lange, Christopher E Cannon, Jason T Drott, Scott D Kuduk, Jason M Uslaner

J Pharmacol Exp Ther· December 2015

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Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Scott D Kuduk, Jason W Skudlarek, Christina N DiMarco, Joseph G Bruno, Mark H Pausch

Bioorg Med Chem Lett· June 2015

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