Publications by authors named "Edgar Jacoby"

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A New Fragment-Based Pharmacophore Virtual Screening Workflow Identifies Potent Inhibitors of SARS-CoV-2 NSP13 Helicase.
Jordi Doijen, Jiexiong Xie, Simone Marsili, Trpta Bains, Mandeep Kaur Mann, Edgar Jacoby

J Comput Chem· September 2025

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Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.
Jay H Kalin, Yanting Yin, Minh T Tran, Madison Piassek, Amy Fung, Edgar Jacoby

J Virol· July 2025

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DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.
Sean M Carney, Sandrine Grosse, Yanting Yin, Minh T Tran, Jay H Kalin, Edgar Jacoby

J Med Chem· March 2025

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Identification of isoquinolinone DHODH inhibitor isosteres.
Lindsey G DeRatt, Zhuming Zhang, E Christine Pietsch, Justin Cisar, Aihua Wang, Edgar Jacoby

Bioorg Med Chem Lett· November 2024

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Direct-acting antivirals for RSV treatment, a review.
Brecht Bonneux, Edgar Jacoby, Martina Ceconi, Kim Stobbelaar, Peter Delputte

Antiviral Res· September 2024

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Structure-Activity Relationship of Oxacyclo- and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors.
Minh T Tran, Sandrine Grosse, Rodrigo J Carbajo, Edgar Jacoby, Yanting Yin

ACS Med Chem Lett· September 2024

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Discovery of -Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors.
Sandrine Grosse, Ludwig Cooymans, Werner Embrechts, David McGowan, Edgar Jacoby

J Med Chem· August 2024

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Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
Lindsey G DeRatt, Zhuming Zhang, Christine Pietsch, Justin S Cisar, Xiaochun Zhang, Edgar Jacoby

J Med Chem· July 2024

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Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections.
Bart Kesteleyn, Florence Herschke, Nicolas Darville, Bart Stoops, Tom Jacobs, Edgar Jacoby

J Med Chem· July 2024

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Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
Lindsey G DeRatt, E Christine Pietsch, Justin S Cisar, Edgar Jacoby, Faraz Kazmi

ACS Med Chem Lett· March 2024

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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Xiaodi Yu, Pravien Abeywickrema, Brecht Bonneux, Ishani Behera, Brandon Anson, Edgar Jacoby

Commun Biol· October 2023

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From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.
Sandrine Grosse, Abdellah Tahri, Pierre Raboisson, Yannis Houpis, Bart Stoops, Edgar Jacoby

ACS Med Chem Lett· December 2022

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-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
Justin S Cisar, Christine Pietsch, Lindsey G DeRatt, Edgar Jacoby, Faraz Kazmi

J Med Chem· August 2022

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Divide and Conquer. Pocket-Opening Mixed-Solvent Simulations in the Perspective of Docking Virtual Screening Applications for Drug Discovery.
Francesc Sabanés Zariquiey, Edgar Jacoby, Ann Vos, Herman W T van Vlijmen, Gary Tresadern

J Chem Inf Model· February 2022

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A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
Lindsey G DeRatt, E Christine Pietsch, Alexandra Tanner, Paul Shaffer, Edgar Jacoby

Bioorg Med Chem Lett· November 2020

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Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro.
Thierry Verbinnen, Ying Tan, Gengyan Wang, Pascale Dehertogh, Karen Vergauwen, Edgar Jacoby

J Antimicrob Chemother· September 2020

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The Future of Computational Chemogenomics.
Edgar Jacoby, J B Brown

Methods Mol Biol· April 2019

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Accessing the Open PHACTS Discovery Platform with Workflow Tools.
Daniela Digles, Andrei Caracoti, Edgar Jacoby

Methods Mol Biol· February 2019

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Protocols for the Design of Kinase-focused Compound Libraries.
Edgar Jacoby, Berthold Wroblowski, Christophe Buyck, Jean-Marc Neefs, Christophe Meyer

Mol Inform· May 2018

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Correction to Structural Investigation of B-Raf Paradox Breaker and Inducer Inhibitors.
Rohit Arora, Michela Di Michele, Elisabeth Stes, Elien Vandermarliere, Lennart Martens, Edgar Jacoby

J Med Chem· July 2016

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Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.
Sebastian K Wandinger, Idoya Lahortiga, Kris Jacobs, Martin Klammer, Nicole Jordan, Edgar Jacoby

PLoS One· June 2016

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Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules.
Michela Di Michele, Elisabeth Stes, Elien Vandermarliere, Rohit Arora, Juan Astorga-Wells, Edgar Jacoby

J Proteome Res· October 2015

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Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.
François Gessier, Joerg Kallen, Edgar Jacoby, Patrick Chène, Thérèse Stachyra-Valat

Bioorg Med Chem Lett· September 2015

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PepShell: visualization of conformational proteomics data.
Elien Vandermarliere, Davy Maddelein, Niels Hulstaert, Elisabeth Stes, Michela Di Michele, Edgar Jacoby

J Proteome Res· April 2015

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Structural investigation of B-Raf paradox breaker and inducer inhibitors.
Rohit Arora, Michela Di Michele, Elisabeth Stes, Elien Vandermarliere, Lennart Martens, Edgar Jacoby

J Med Chem· February 2015

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