Publications by authors named "Justin Cisar"

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Toward Dose Prediction at Point of Design.
Dries Van Rompaey, Siladitya Ray Chaudhuri, Mazen Ahmad, Justin Cisar, An Van Den Bergh

J Med Chem· December 2024

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Identification of isoquinolinone DHODH inhibitor isosteres.
Lindsey G DeRatt, Zhuming Zhang, E Christine Pietsch, Justin Cisar, Aihua Wang

Bioorg Med Chem Lett· November 2024

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Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
Lindsey G DeRatt, Zhuming Zhang, Christine Pietsch, Justin S Cisar, Xiaochun Zhang

J Med Chem· July 2024

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Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
Lindsey G DeRatt, E Christine Pietsch, Justin S Cisar, Edgar Jacoby, Faraz Kazmi

ACS Med Chem Lett· March 2024

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-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
Justin S Cisar, Christine Pietsch, Lindsey G DeRatt, Edgar Jacoby, Faraz Kazmi

J Med Chem· August 2022

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Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis.
Thomas J Struble, Juan C Alvarez, Scott P Brown, Milan Chytil, Justin Cisar

J Med Chem· August 2020

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Quantification of In Vivo Target Engagement Using Microfluidic Activity-Based Protein Profiling.
Holly T Reardon, Rachel A Herbst, Cassandra L Henry, Dylan M Herbst, Nhi Ngo, Justin S Cisar

SLAS Technol· October 2019

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Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.
Jason R Clapper, Cassandra L Henry, Micah J Niphakis, Anna M Knize, Aundrea R Coppola, Justin S Cisar

J Pharmacol Exp Ther· December 2018

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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.
Justin S Cisar, Olivia D Weber, Jason R Clapper, Jacqueline L Blankman, Cassandra L Henry

J Med Chem· October 2018

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Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
Shichun Lun, Haidan Guo, John Adamson, Justin S Cisar, Tony D Davis

Antimicrob Agents Chemother· October 2013

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Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.
Jing Li, Justin S Cisar, Cong-Ying Zhou, Brunilda Vera, Howard Williams

Nat Chem· June 2013

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Activity-based labeling of matrix metalloproteinases in living vertebrate embryos.
Jonathan Y Keow, Eric D Pond, Justin S Cisar, Benjamin F Cravatt, Bryan D Crawford

PLoS One· February 2013

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Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.
Justin S Cisar, Benjamin F Cravatt

J Am Chem Soc· June 2012

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Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids.
Jonathan Z Long, Justin S Cisar, David Milliken, Sherry Niessen, Chu Wang

Nat Chem Biol· September 2011

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Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
Xuequan Lu, Shaun K Olsen, Allan D Capili, Justin S Cisar, Christopher D Lima

J Am Chem Soc· February 2010

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Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.
Justin S Cisar, Derek S Tan

Chem Soc Rev· July 2008

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Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.
Justin S Cisar, Julian A Ferreras, Rajesh K Soni, Luis E N Quadri, Derek S Tan

J Am Chem Soc· June 2007

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Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds.
Jie Song, Justin S Cisar, Carolyn R Bertozzi

J Am Chem Soc· July 2004

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