Publications by authors named "George D Hartman"

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Diazepinone HBV capsid assembly modulators.
Scott D Kuduk, Lindsey G DeRatt, Bart Stoops, Paul Shaffer, Angela M Lam, George D Hartman

Bioorg Med Chem Lett· September 2022

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Oxadiazepinone HBV capsid assembly modulators.
Scott D Kuduk, Bart Stoops, Angela M Lam, Christine Espiritu, Robert Vogel, George D Hartman

Bioorg Med Chem Lett· November 2021

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Identification of a new class of HBV capsid assembly modulator.
Scott D Kuduk, Bart Stoops, Richard Alexander, Angela M Lam, Christine Espiritu, George D Hartman

Bioorg Med Chem Lett· May 2021

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450s nder striction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals.
George D Hartman, Scott D Kuduk, Christine Espiritu, Angela M Lam

ACS Med Chem Lett· October 2020

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SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.
Scott D Kuduk, Angela M Lam, Christine Espiritu, Robert Vogel, Vincent Lau, George D Hartman

Bioorg Med Chem Lett· August 2019

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Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.
Angela M Lam, Christine Espiritu, Robert Vogel, Suping Ren, Vincent Lau, George D Hartman

Antimicrob Agents Chemother· January 2019

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MK-7622: A First-in-Class M Positive Allosteric Modulator Development Candidate.
Douglas C Beshore, Christina N Di Marco, Ronald K Chang, Thomas J Greshock, Lei Ma, George D Hartman

ACS Med Chem Lett· July 2018

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Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants.
Angela M Lam, Suping Ren, Christine Espiritu, Mollie Kelly, Vincent Lau, George D Hartman

Antimicrob Agents Chemother· August 2017

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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Scott E Wolkenberg, M Brad Nolt, Mark T Bilodeau, B Wesley Trotter, Peter J Manley, George D Hartman

Bioorg Med Chem Lett· February 2017

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Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Thomas S Reger, M Christa Mattern, Swati P Mercer, Jeffrey M Bergman, George D Hartman

Bioorg Med Chem Lett· October 2014

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Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.
Antonella Converso, Timothy Hartingh, Mark E Fraley, Robert M Garbaccio, George D Hartman

Bioorg Med Chem Lett· June 2014

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Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.
Zhi-Qiang Yang, Youheng Shu, Lei Ma, Marion Wittmann, William J Ray, George D Hartman

ACS Med Chem Lett· May 2014

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Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.
Scott D Kuduk, Christina N Di Marco, Jonathan R Saffold, William J Ray, Lei Ma, George D Hartman

Bioorg Med Chem Lett· March 2014

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Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Swati P Mercer, John D Schreier, Christopher D Cox, Mark E Fraley, George D Hartman

ChemMedChem· February 2014

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Benzimidazole CB2 agonists: design, synthesis and SAR.
Kausik K Nanda, Darrell A Henze, Kimberly Della Penna, Reshma Desai, Michael Leitl, George D Hartman

Bioorg Med Chem Lett· February 2014

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Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Swati P Mercer, Anthony J Roecker, Susan Garson, Duane R Reiss, C Meacham Harrell, George D Hartman

Bioorg Med Chem Lett· December 2013

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Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.
Scott D Kuduk, Ronald K Chang, Thomas J Greshock, William J Ray, Lei Ma, George D Hartman

ACS Med Chem Lett· December 2012

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Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.
Vadim Y Dudkin, Cheng Wang, Kenneth L Arrington, Mark E Fraley, George D Hartman

Bioorg Med Chem Lett· April 2012

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Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.
Vadim Y Dudkin, Keith Rickert, Constantine Kreatsoulas, Cheng Wang, Kenneth L Arrington, George D Hartman

Bioorg Med Chem Lett· April 2012

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Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Paul J Coleman, John D Schreier, Christopher D Cox, Michael J Breslin, David B Whitman, George D Hartman

ChemMedChem· March 2012

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Discovery of selective glucocorticoid receptor modulator MK-5932.
Christopher J Bungard, George D Hartman, Jesse J Manikowski, James J Perkins, Chang Bai

Bioorg Med Chem· December 2011

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Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3).
Scott D Kuduk, Ronald K Chang, Christina N Di Marco, Robert M Dipardo, Sean P Cook, George D Hartman

Bioorg Med Chem Lett· July 2011

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Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.
Scott D Kuduk, Ronald K Chang, Christina N Di Marco, Daniel R Pitts, Thomas J Greshock, George D Hartman

J Med Chem· July 2011

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Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328.
Scott T Harrison, James Mulhearn, Scott E Wolkenberg, Patricia J Miller, Stacey S O'Malley, George D Hartman

ACS Med Chem Lett· July 2011

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Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.
B Wesley Trotter, Kausik K Nanda, Christopher S Burgey, Craig M Potteiger, James Z Deng, George D Hartman

Bioorg Med Chem Lett· April 2011

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