Publications by authors named "Timothy Hartingh"

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Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease.
Rajini R Mudhasani, Joseph W Golden, Gregory C Adam, Timothy J Hartingh, Krishna P Kota

Microbiol Spectr· April 2024

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Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
Valerie W Shurtleff, Mark E Layton, Craig A Parish, James J Perkins, John D Schreier, Timothy J Hartingh

J Med Chem· March 2024

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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
Mark E Layton, Jeffrey C Kern, Timothy J Hartingh, William D Shipe, Izzat Raheem

J Med Chem· January 2023

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Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.
John D Schreier, Mark W Embrey, Izzat T Raheem, Guillaume Barbe, Louis-Charles Campeau, Timothy J Hartingh

Bioorg Med Chem Lett· May 2017

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Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.
Mark E Layton, Alexander J Reif, Timothy J Hartingh, Kevin Rodzinak, Vadim Dudkin

Bioorg Med Chem Lett· February 2016

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Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Izzat T Raheem, Abbas M Walji, Daniel Klein, John M Sanders, David A Powell, Timothy J Hartingh

J Med Chem· January 2016

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Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Izzat T Raheem, Abbas M Walji, Daniel Klein, John M Sanders, David A Powell, Timothy J Hartingh

J Med Chem· October 2015

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Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.
Antonella Converso, Timothy Hartingh, Mark E Fraley, Robert M Garbaccio, George D Hartman

Bioorg Med Chem Lett· June 2014

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Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.
Antonella Converso, Timothy Hartingh, Robert M Garbaccio, Edward Tasber, Keith Rickert

Bioorg Med Chem Lett· February 2009

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