Publications by authors named "William D Shipe"

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Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
Valerie W Shurtleff, Mark E Layton, Craig A Parish, James J Perkins, John D Schreier, William D Shipe

J Med Chem· March 2024

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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
Mark E Layton, Jeffrey C Kern, Timothy J Hartingh, William D Shipe, Izzat Raheem

J Med Chem· January 2023

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A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Keith P Moore, Adam G Schwaid, Matthew Tudor, Sangho Park, Douglas C Beshore, William D Shipe

ACS Chem Biol· September 2022

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The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Ashley B Forster, Pravien Abeywickrema, Jaime Bunda, Christopher D Cox, Tamara D Cabalu, William D Shipe

Bioorg Med Chem Lett· December 2017

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
John M Sanders, Douglas C Beshore, J Christopher Culberson, James I Fells, Jason E Imbriglio, William D Shipe

J Med Chem· August 2017

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Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group.
Christopher J Bungard, Peter D Williams, Jeanine E Ballard, David J Bennett, Christian Beaulieu, William D Shipe

ACS Med Chem Lett· July 2016

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Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Izzat T Raheem, John D Schreier, Joy Fuerst, Liza Gantert, Eric D Hostetler, William D Shipe

Bioorg Med Chem Lett· January 2016

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Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.
William D Shipe, Steven S Sharik, James C Barrow, Georgia B McGaughey, Cory R Theberge

J Med Chem· October 2015

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Accelerating lead development by microwave-enhanced medicinal chemistry.
William D Shipe, Scott E Wolkenberg, Craig W Lindsley

Drug Discov Today Technol· July 2014

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Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.
Feng V Yang, William D Shipe, Jaime L Bunda, M Brad Nolt, David D Wisnoski

Bioorg Med Chem Lett· January 2010

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Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Zhi-Qiang Yang, James C Barrow, William D Shipe, Kelly-Ann S Schlegel, Youheng Shu

J Med Chem· October 2008

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Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
William D Shipe, James C Barrow, Zhi-Qiang Yang, Craig W Lindsley, F Vivien Yang

J Med Chem· July 2008

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Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia.
Craig W Lindsley, William D Shipe, Scott E Wolkenberg, Cory R Theberge, David L Williams

Curr Top Med Chem· September 2006

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Convergent, enantioselective syntheses of guanacastepenes A and E featuring a selective cyclobutane fragmentation.
William D Shipe, Erik J Sorensen

J Am Chem Soc· May 2006

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Applications of microwave-assisted organic synthesis on the multigram scale.
Scott E Wolkenberg, William D Shipe, Craig W Lindsley, James P Guare, Joseph M Pawluczyk

Curr Opin Drug Discov Devel· November 2005

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Recent advances in positive allosteric modulators of metabotropic glutamate receptors.
William D Shipe, Scott E Wolkenberg, David L Williams, Craig W Lindsley

Curr Opin Drug Discov Devel· July 2005

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A convergent synthesis of the tricyclic architecture of the guanacastepenes featuring a selective ring fragmentation.
William D Shipe, Erik J Sorensen

Org Lett· June 2002

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