Publications by authors named "David D Wisnoski"

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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Philip A Harris, Nicolas Faucher, Nicolas George, Patrick M Eidam, Bryan W King, David D Wisnoski

J Med Chem· May 2019

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
Philip A Harris, Scott B Berger, Jae U Jeong, Rakesh Nagilla, Deepak Bandyopadhyay, David D Wisnoski

J Med Chem· February 2017

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Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.
Zining Wu, Todd L Graybill, Xin Zeng, Michael Platchek, Jean Zhang, David D Wisnoski

ACS Comb Sci· December 2015

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Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.
Adam K Charnley, Máire A Convery, Ami Lakdawala Shah, Emma Jones, Philip Hardwicke, David D Wisnoski

Bioorg Med Chem· November 2015

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-NITRO--SUBSTITUTED GUANIDINES: A SIMPLE CLASS OF NITRIC OXIDE SYNTHASE INHIBITORS.
Christophe D Guillon, David D Wisnoski, Jaya Saxena, Ned D Heindel, Diane E Heck

Mod Res Inflamm· May 2014

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Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy.
Karen A Evans, Barry G Shearer, David D Wisnoski, Dongchuan Shi, Steven M Sparks

Bioorg Med Chem Lett· April 2011

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Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists.
Brian W Budzik, Karen A Evans, David D Wisnoski, Jian Jin, Ralph A Rivero

Bioorg Med Chem Lett· February 2010

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Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.
Feng V Yang, William D Shipe, Jaime L Bunda, M Brad Nolt, David D Wisnoski

Bioorg Med Chem Lett· January 2010

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Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.
Karen A Evans, Brian W Budzik, Sean A Ross, David D Wisnoski, Jian Jin

J Med Chem· December 2009

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Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Scott E Wolkenberg, Zhijian Zhao, David D Wisnoski, William H Leister, Julie O'Brien

Bioorg Med Chem Lett· March 2009

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Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
Zhijian Zhao, David D Wisnoski, Julie A O'Brien, Wei Lemaire, David L Williams

Bioorg Med Chem Lett· March 2007

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p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.
Swaminathan R Natarajan, David D Wisnoski, James E Thompson, Edward A O'Neill, Stephen J O'Keefe

Bioorg Med Chem Lett· August 2006

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Acetonitrile/water gas-phase reaction products observed by use of atmospheric pressure chemical ionization: adducts formed with sulfonamides.
Charles W Ross, Arthur B Coddington, Joan S Murphy, David D Wisnoski, C Blair Zartman

Rapid Commun Mass Spectrom· May 2005

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
Gene G Kinney, Julie A O'Brien, Wei Lemaire, Maryann Burno, Denise J Bickel, David D Wisnoski

J Pharmacol Exp Ther· April 2005

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Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
Craig W Lindsley, David D Wisnoski, William H Leister, Julie A O'brien, Wei Lemaire

J Med Chem· November 2004

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.
Julie A O'Brien, Wei Lemaire, Marion Wittmann, Marlene A Jacobson, Sookhee N Ha, David D Wisnoski

J Pharmacol Exp Ther· May 2004

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Efficient synthesis of imidazoles from aldehydes and 1,2-diketones using microwave irradiation.
Scott E Wolkenberg, David D Wisnoski, William H Leister, Yi Wang, Zhijian Zhao

Org Lett· April 2004

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Difference in mGluR5 interaction between positive allosteric modulators from two structural classes.
David L Williams, Julie A O'Brien, Wei Lemaire, Tsing-Bau Chen, Raymond S L Chang, David D Wisnoski

Ann N Y Acad Sci· November 2003

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p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.
Swaminathan R Natarajan, David D Wisnoski, Suresh B Singh, John E Stelmach, Edward A O'Neill

Bioorg Med Chem Lett· January 2003

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