Publications by authors named "Suresh B Singh"

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Discovery of Potent Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 Using a Novel Growth-Based Protocol of Screening and Optimization in CONTOUR.
Zhijie Liu, Suresh B Singh, Yajun Zheng, Peter Lindblom, Colin Tice

J Chem Inf Model· August 2019

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Conformational control in structure-based drug design.
Yajun Zheng, Colin M Tice, Suresh B Singh

Bioorg Med Chem Lett· July 2017

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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor.
Linghang Zhuang, Colin M Tice, Zhenrong Xu, Wei Zhao, Salvacion Cacatian, Suresh B Singh

Bioorg Med Chem· July 2017

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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Colin M Tice, Paul B Noto, Kristi Yi Fan, Wei Zhao, Stephen D Lotesta, Suresh B Singh

Bioorg Med Chem Lett· October 2016

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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Yajun Zheng, Linghang Zhuang, Kristi Yi Fan, Colin M Tice, Wei Zhao, Suresh B Singh

J Med Chem· April 2016

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.
Stephen D Lotesta, Andrew P Marcus, Yajun Zheng, Katerina Leftheris, Paul B Noto, Suresh B Singh

Bioorg Med Chem· March 2016

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The medicinal chemistry of liver X receptor (LXR) modulators.
Colin M Tice, Paul B Noto, Kristi Yi Fan, Linghang Zhuang, Deepak S Lala, Suresh B Singh

J Med Chem· September 2014

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An electronic environment and contact direction sensitive scoring function for predicting affinities of protein-ligand complexes in Contour(®).
Peter R Lindblom, Guosheng Wu, Zhijie Liu, Kam-Chuen Jim, John J Baldwin, Suresh B Singh

J Mol Graph Model· September 2014

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The use of spirocyclic scaffolds in drug discovery.
Yajun Zheng, Colin M Tice, Suresh B Singh

Bioorg Med Chem Lett· August 2014

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Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.
Jing Yuan, Shankar Venkatraman, Yajun Zheng, Brian M McKeever, Lawrence W Dillard, Suresh B Singh

J Med Chem· June 2013

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Structure-based design technology contour and its application to the design of renin inhibitors.
Alexey Ishchenko, Zhijie Liu, Peter Lindblom, Guosheng Wu, Kam-Chuen Jim, Suresh B Singh

J Chem Inf Model· August 2012

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Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
Lanqi Jia, Robert D Simpson, Jing Yuan, Zhenrong Xu, Wei Zhao, Suresh B Singh

ACS Med Chem Lett· October 2011

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Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1.
Zhenrong Xu, Colin M Tice, Wei Zhao, Salvacion Cacatian, Yuan-Jie Ye, Suresh B Singh

J Med Chem· September 2011

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Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.
Jing Yuan, Robert D Simpson, Wei Zhao, Colin M Tice, Zhenrong Xu, Suresh B Singh

Bioorg Med Chem Lett· August 2011

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Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1.
Colin M Tice, Wei Zhao, Paula M Krosky, Barbara A Kruk, Jennifer Berbaum, Suresh B Singh

Bioorg Med Chem Lett· November 2010

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Spirocyclic ureas: orally bioavailable 11 beta-HSD1 inhibitors identified by computer-aided drug design.
Colin M Tice, Wei Zhao, Zhenrong Xu, Salvacion T Cacatian, Robert D Simpson, Suresh B Singh

Bioorg Med Chem Lett· February 2010

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Optimization of orally bioavailable alkyl amine renin inhibitors.
Zhenrong Xu, Salvacion Cacatian, Jing Yuan, Robert D Simpson, Lanqi Jia, Suresh B Singh

Bioorg Med Chem Lett· January 2010

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Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
Colin M Tice, Zhenrong Xu, Jing Yuan, Robert D Simpson, Salvacion T Cacatian, Suresh B Singh

Bioorg Med Chem Lett· July 2009

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Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors.
Meng-Hsin Chen, Patricia Fitzgerald, Suresh B Singh, Edward A O'Neill, Cheryl D Schwartz

Bioorg Med Chem Lett· March 2008

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p38 MAP kinase inhibitors. Part 6: 2-arylpyridazin-3-ones as templates for inhibitor design.
Swaminathan R Natarajan, Stephen T Heller, Kiyean Nam, Suresh B Singh, Giovanna Scapin

Bioorg Med Chem Lett· November 2006

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Selective inhibition of dog hepatic CYP2B11 and CYP3A12.
Ping Lu, Suresh B Singh, Brian A Carr, Yulin Fang, Cathie Dong Xiang

J Pharmacol Exp Ther· May 2005

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Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.
Giovanna Scapin, Sangita B Patel, Christine Chung, Jeffrey P Varnerin, Scott D Edmondson, Suresh B Singh

Biochemistry· May 2004

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SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors.
Luping Liu, John E Stelmach, Swaminathan R Natarajan, Meng-Hsin Chen, Suresh B Singh

Bioorg Med Chem Lett· November 2003

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Text Influenced Molecular Indexing (TIMI): a literature database mining approach that handles text and chemistry.
Suresh B Singh, Richard D Hull, Eugene M Fluder

J Chem Inf Comput Sci· October 2003

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The role of tryptophan 1072 in human PDE3B inhibitor binding.
Christine Chung, Jeffrey P Varnerin, Nancy R Morin, Douglas J MacNeil, Suresh B Singh

Biochem Biophys Res Commun· August 2003

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