Publications by authors named "Douglas J MacNeil"

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Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes.
Joshua D Frenster, Michael Kader, Scott Kamen, James Sun, Luis Chiriboga, Douglas J MacNeil

Neurooncol Adv· April 2020

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Imidazopyridyl compounds as aldosterone synthase inhibitors.
Brent R Whitehead, Michael M-C Lo, Amjad Ali, Min K Park, Scott B Hoyt, Douglas J MacNeil

Bioorg Med Chem Lett· January 2017

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Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
Whitney L Petrilli, Scott B Hoyt, Clare London, Daniel McMasters, Andreas Verras, Douglas J MacNeil

ACS Med Chem Lett· January 2017

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The role of melanin-concentrating hormone and its receptors in energy homeostasis.
Douglas J Macneil

Front Endocrinol (Lausanne)· April 2013

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A miniaturized homogenous assay of mitochondrial membrane potential.
Aurawan Vongs, Kelli J Solly, Laszlo Kiss, Douglas J Macneil, Charles I Rosenblum

Assay Drug Dev Technol· August 2011

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Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
Liping Wang, James A Hubert, Susan J Lee, Jie Pan, Su Qian, Douglas J MacNeil

Bioorg Med Chem Lett· May 2011

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Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes.
Hua Zhong, John Beaulaurier, Pek Yee Lum, Cliona Molony, Xia Yang, Douglas J Macneil

PLoS Genet· May 2010

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Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.
Ryuichi Moriya, Toru Fujikawa, Junko Ito, Takashi Shirakura, Hiroyasu Hirose, Douglas J Macneil

Eur J Pharmacol· February 2010

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Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.
Masahiko Ito, Akane Ishihara, Akira Gomori, Shinichiro Egashira, Hiroko Matsushita, Douglas J MacNeil

Eur J Pharmacol· December 2009

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MCH receptor peptide agonists and antagonists.
Douglas J MacNeil, Maria A Bednarek

Peptides· November 2009

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In vivo optical imaging of LacZ expression using lacZ transgenic mice.
Guo-Jun Zhang, Tsing-Bau Chen, Brett Connolly, Shu-An Lin, Richard Hargreaves, Douglas J Macneil

Assay Drug Dev Technol· August 2009

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Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.
Xia Yang, Joshua L Deignan, Hongxiu Qi, Jun Zhu, Su Qian, Douglas J Macneil

Nat Genet· April 2009

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Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.
Toshihiro Sakamoto, Minoru Moriya, Yuji Haga, Toshiyuki Takahashi, Takunobu Shibata, Douglas J Macneil

Bioorg Med Chem Lett· March 2009

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2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.
Richard Berger, Cheng Zhu, Alexa R Hansen, Bart Harper, Zhesheng Chen, Douglas J Macneil

Bioorg Med Chem Lett· September 2008

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Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.
Makoto Ito, Akira Gomori, Jun Suzuki, Shigeharu Tsujioka, Minoru Sasaki, Douglas J Macneil

J Endocrinol· August 2008

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Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.
Su Qian, Sheena Mumick, Peter Nizner, Michael R Tota, Joseph Menetski, Douglas J Macneil

Basic Clin Pharmacol Toxicol· July 2008

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Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine.
Satoshi Mashiko, Akane Ishihara, Hisashi Iwaasa, Ryuichi Moriya, Hidefumi Kitazawa, Douglas J MacNeil

Obesity (Silver Spring)· July 2008

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Variations in DNA elucidate molecular networks that cause disease.
Yanqing Chen, Jun Zhu, Pek Yee Lum, Xia Yang, Shirly Pinto, Douglas J MacNeil

Nature· March 2008

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NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs.
Douglas J MacNeil

Curr Top Med Chem· February 2008

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Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.
Lauren P Shearman, D Sloan Stribling, Ramon E Camacho, Kimberly M Rosko, Junying Wang, Douglas J Macneil

Eur J Pharmacol· January 2008

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Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults.
Ira Gantz, Ngozi Erondu, Madhuja Mallick, Bret Musser, Rajesh Krishna, Douglas J Macneil

J Clin Endocrinol Metab· May 2007

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A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
Satoshi Mashiko, Akane Ishihara, Hisashi Iwaasa, Hideki Sano, Junko Ito, Douglas J MacNeil

Mol Pharmacol· February 2007

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2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists.
Jinlong Jiang, Myle Hoang, Jonathan R Young, Danny Chaung, Ronsar Eid, Douglas J MacNeil

Bioorg Med Chem Lett· October 2006

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Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.
Ngozi Erondu, Ira Gantz, Bret Musser, Shailaja Suryawanshi, Madhuja Mallick, Douglas J MacNeil

Cell Metab· October 2006

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Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.
Ryo Yoshimoto, Yasuhisa Miyamoto, Ken Shimamura, Akane Ishihara, Kazuhiko Takahashi, Douglas J Macneil

Proc Natl Acad Sci U S A· September 2006

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