Publications by authors named "Brian M McKeever"

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A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
Andrei V Krivtsov, Kathryn Evans, Jayant Y Gadrey, Benjamin K Eschle, Charlie Hatton, Brian M McKeever

Cancer Cell· December 2019

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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor.
Linghang Zhuang, Colin M Tice, Zhenrong Xu, Wei Zhao, Salvacion Cacatian, Brian M McKeever

Bioorg Med Chem· July 2017

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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Colin M Tice, Paul B Noto, Kristi Yi Fan, Wei Zhao, Stephen D Lotesta, Brian M McKeever

Bioorg Med Chem Lett· October 2016

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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Yajun Zheng, Linghang Zhuang, Kristi Yi Fan, Colin M Tice, Wei Zhao, Brian M McKeever

J Med Chem· April 2016

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Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.
Jing Yuan, Shankar Venkatraman, Yajun Zheng, Brian M McKeever, Lawrence W Dillard

J Med Chem· June 2013

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New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin.
Manne Krop, Xifeng Lu, Koen Verdonk, Maarten A D H Schalekamp, Jeanette M G van Gool, Brian M McKeever

Hypertension· May 2013

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Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.
Paul B Noto, Yuri Bukhtiyarov, Meng Shi, Brian M McKeever, Gerard M McGeehan

Mol Pharmacol· October 2012

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Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
Lanqi Jia, Robert D Simpson, Jing Yuan, Zhenrong Xu, Wei Zhao, Brian M McKeever

ACS Med Chem Lett· October 2011

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Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1.
Zhenrong Xu, Colin M Tice, Wei Zhao, Salvacion Cacatian, Yuan-Jie Ye, Brian M McKeever

J Med Chem· September 2011

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Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.
Jing Yuan, Robert D Simpson, Wei Zhao, Colin M Tice, Zhenrong Xu, Brian M McKeever

Bioorg Med Chem Lett· August 2011

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Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1.
Colin M Tice, Wei Zhao, Paula M Krosky, Barbara A Kruk, Jennifer Berbaum, Brian M McKeever

Bioorg Med Chem Lett· November 2010

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Spirocyclic ureas: orally bioavailable 11 beta-HSD1 inhibitors identified by computer-aided drug design.
Colin M Tice, Wei Zhao, Zhenrong Xu, Salvacion T Cacatian, Robert D Simpson, Brian M McKeever

Bioorg Med Chem Lett· February 2010

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Optimization of orally bioavailable alkyl amine renin inhibitors.
Zhenrong Xu, Salvacion Cacatian, Jing Yuan, Robert D Simpson, Lanqi Jia, Brian M McKeever

Bioorg Med Chem Lett· January 2010

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Expression, purification and crystallization of human 5-lipoxygenase-activating protein with leukotriene-biosynthesis inhibitors.
Shihua Xu, Brian M McKeever, Douglas Wisniewski, Douglas K Miller, Robert H Spencer

Acta Crystallogr Sect F Struct Biol Cryst Commun· December 2007

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Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
Andrew D Ferguson, Brian M McKeever, Shihua Xu, Douglas Wisniewski, Douglas K Miller

Science· July 2007

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Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
Guo Q Shi, James F Dropinski, Brian M McKeever, Shihua Xu, Joseph W Becker

J Med Chem· June 2005

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Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics.
Brian M McKeever, Barton K Hawkins, Wayne M Geissler, Ling Wu, Robert P Sheridan

Biochim Biophys Acta· November 2002

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