Publications by authors named "Charlie Hatton"

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KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.
Nicole L Michmerhuizen, Emily B Heikamp, Ilaria Iacobucci, Masayuki Umeda, Bright Arthur, Charlie Hatton

Cancer Discov· October 2025

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High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity.
James B Shaum, Miquel Muñoz I Ordoño, Erica A Steen, Daniela V Wenge, Hakyung Cheong, Charlie Hatton

bioRxiv· September 2025

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Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer.
Sarah Naomi Olsen, Bryn Anderson, Charlie Hatton, Zhengtao Chu, Christopher Simpkins

Cell Rep Med· July 2025

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NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive gene expression in AML.
Emily B Heikamp, Cynthia Martucci, Jill A Henrich, Dana S Neel, Sanisha Mahendra-Rajah, Charlie Hatton

Cell Rep· November 2024

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Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Wallace Bourgeois, Jevon A Cutler, Brandon J Aubrey, Daniela V Wenge, Florian Perner, Charlie Hatton

Blood· April 2024

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Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.
Jonathan Paolino, Boris Dimitrov, Beth Apsel Winger, Angelica Sandoval-Perez, Amith Vikram Rangarajan, Charlie Hatton

Clin Cancer Res· November 2023

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KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.
Leslie Duplaquet, Yixiang Li, Matthew A Booker, Yingtian Xie, Sarah Naomi Olsen, Charlie Hatton

Nat Cell Biol· September 2023

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UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Jonathan M Tsai, Jacob D Aguirre, Yen-Der Li, Jared Brown, Vivian Focht, Charlie Hatton

Mol Cell· August 2023

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Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.
Hannah J Uckelmann, Elena L Haarer, Reina Takeda, Eric M Wong, Charlie Hatton

Cancer Discov· March 2023

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MEN1 mutations mediate clinical resistance to menin inhibition.
Florian Perner, Eytan M Stein, Daniela V Wenge, Sukrit Singh, Jeonghyeon Kim, Charlie Hatton

Nature· March 2023

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MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.
Matthew L Hemming, Morgan R Benson, Michael A Loycano, Justin A Anderson, Jessica L Andersen, Charlie Hatton

Cancer Discov· July 2022

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IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.
Brandon J Aubrey, Jevon A Cutler, Wallace Bourgeois, Katherine A Donovan, Shengqing Gu, Charlie Hatton

Nat Cancer· May 2022

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A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
Andrei V Krivtsov, Kathryn Evans, Jayant Y Gadrey, Benjamin K Eschle, Charlie Hatton

Cancer Cell· December 2019

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An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.
Brian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, Paul Labhart, Gulfem D Guler, Charlie Hatton

PLoS One· June 2017

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Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment.
Yinshi Huang, Sabikun Nahar, Akifumi Nakagawa, Maite G Fernandez-Barrena, Jennifer A Mertz, Charlie Hatton

Clin Cancer Res· August 2016

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Correction: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.
Andrew R Conery, Richard C Centore, Adrianne Neiss, Patricia J Keller, Shivangi Joshi, Charlie Hatton

Elife· July 2016

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Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
Srimoyee Ghosh, Alexander Taylor, Melissa Chin, Hon-Ren Huang, Andrew R Conery, Charlie Hatton

J Biol Chem· June 2016

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Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.
John P McGrath, Kaylyn E Williamson, Srividya Balasubramanian, Shobu Odate, Shilpi Arora, Charlie Hatton

Cancer Res· April 2016

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Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response.
Andrew R Conery, Richard C Centore, Kerry L Spillane, Nicole E Follmer, Archana Bommi-Reddy, Charlie Hatton

Cancer Res· March 2016

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Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.
Andrew R Conery, Richard C Centore, Adrianne Neiss, Patricia J Keller, Shivangi Joshi, Charlie Hatton

Elife· January 2016

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Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
Laura E MacConaill, Elizabeth Garcia, Priyanka Shivdasani, Matthew Ducar, Ravali Adusumilli, Charlie Hatton

J Mol Diagn· November 2014

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EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.
William D Bradley, Shilpi Arora, Jennifer Busby, Srividya Balasubramanian, Victor S Gehling, Charlie Hatton

Chem Biol· November 2014

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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Courtney A Lovejoy, Wendi Li, Steven Reisenweber, Supawat Thongthip, Joanne Bruno, Charlie Hatton

PLoS Genet· January 2013

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High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.
Michael K Kiessling, Patrick A Oberholzer, Chandrani Mondal, Maria B Karpova, Marie C Zipser, Charlie Hatton

Blood· February 2011

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Drug-sensitive FGFR2 mutations in endometrial carcinoma.
Amit Dutt, Helga B Salvesen, Tzu-Hsiu Chen, Alex H Ramos, Robert C Onofrio, Charlie Hatton

Proc Natl Acad Sci U S A· June 2008

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