Publications by authors named "Joseph W Becker"

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Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.
Sheo B Singh, John G Ondeyka, Kithsiri B Herath, Chaowei Zhang, Hiranthi Jayasuriya, Joseph W Becker

Bioorg Med Chem Lett· August 2009

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The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.
Sangita B Patel, Patricia M Cameron, Stephen J O'Keefe, Betsy Frantz-Wattley, Jed Thompson, Joseph W Becker

Acta Crystallogr D Biol Crystallogr· August 2009

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Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.
Stephen M Soisson, Gopalakrishnan Parthasarathy, Alan D Adams, Soumya Sahoo, Ayesha Sitlani, Joseph W Becker

Proc Natl Acad Sci U S A· April 2008

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Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae.
Gopalakrishnan Parthasarathy, Richard Cummings, Joseph W Becker, Stephen M Soisson

Acta Crystallogr D Biol Crystallogr· February 2008

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The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.
Monica Einstein, Taro E Akiyama, Gino A Castriota, Chuanlin F Wang, Brian McKeever, Joseph W Becker

Mol Pharmacol· January 2008

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Expression, purification and crystallization of human 5-lipoxygenase-activating protein with leukotriene-biosynthesis inhibitors.
Shihua Xu, Brian M McKeever, Douglas Wisniewski, Douglas K Miller, Robert H Spencer, Joseph W Becker

Acta Crystallogr Sect F Struct Biol Cryst Commun· December 2007

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Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
Andrew D Ferguson, Brian M McKeever, Shihua Xu, Douglas Wisniewski, Douglas K Miller, Joseph W Becker

Science· July 2007

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Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.
Livia Casciola-Rosen, Margarita Garcia-Calvo, Herbert G Bull, Joseph W Becker, Tonie Hines

J Biol Chem· February 2007

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Jun Wang, Stephen M Soisson, Katherine Young, Wesley Shoop, Srinivas Kodali, Joseph W Becker

Nature· May 2006

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Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
Ernest Asante-Appiah, Sangita Patel, Caroline Desponts, Jillian M Taylor, Cheuk Lau, Joseph W Becker

J Biol Chem· March 2006

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Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
Guo Q Shi, James F Dropinski, Brian M McKeever, Shihua Xu, Joseph W Becker

J Med Chem· June 2005

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Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Joseph W Becker, Jennifer Rotonda, Stephen M Soisson, Renee Aspiotis, Christopher Bayly

J Med Chem· May 2004

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Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.
Giovanna Scapin, Sangita B Patel, Christine Chung, Jeffrey P Varnerin, Scott D Edmondson, Joseph W Becker

Biochemistry· May 2004

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Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Yongxin Han, André Giroux, Erich L Grimm, Renée Aspiotis, Sébastien Francoeur, Joseph W Becker

Bioorg Med Chem Lett· February 2004

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Crystallization and preliminary X-ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B.
Sangita B Patel, Jeffrey P Varnerin, Michael R Tota, Scott D Edmondson, Emma R Parmee, Joseph W Becker

Acta Crystallogr D Biol Crystallogr· January 2004

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Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.
Sangita B Patel, Patricia M Cameron, Betsy Frantz-Wattley, Edward O'Neill, Joseph W Becker

Biochim Biophys Acta· January 2004

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The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
Giovanna Scapin, Sangita B Patel, Joseph W Becker, Qingping Wang, Caroline Desponts

Biochemistry· October 2003

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Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.
Catherine E Fitzgerald, Sangita B Patel, Joseph W Becker, Patricia M Cameron, Dennis Zaller

Nat Struct Biol· September 2003

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Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B.
Yolanda Romsicki, Giovanna Scapin, Veronique Beaulieu-Audy, Sangita Patel, Joseph W Becker

J Biol Chem· August 2003

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The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.
Giovanna Scapin, Sangita B Patel, JeanMarie Lisnock, Joseph W Becker, Philip V LoGrasso

Chem Biol· August 2003

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The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.
Ernest Asante-Appiah, Sangita Patel, Claude Dufresne, Patrick Roy, Qingping Wang, Joseph W Becker

Biochemistry· July 2002

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