Publications by authors named "Andre Giroux"

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Trisubstituted ureas as potent and selective mPGES-1 inhibitors.
Jean-François Chiasson, Louise Boulet, Christine Brideau, Anh Chau, David Claveau, André Giroux

Bioorg Med Chem Lett· March 2011

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Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
André Giroux, Louise Boulet, Christine Brideau, Anh Chau, David Claveau

Bioorg Med Chem Lett· October 2009

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MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
Daigen Xu, Steven E Rowland, Patsy Clark, André Giroux, Bernard Côté

J Pharmacol Exp Ther· September 2008

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Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.
Yongxin Han, Michel Belley, Christopher I Bayly, John Colucci, Claude Dufresne, Andre Giroux

Bioorg Med Chem Lett· June 2008

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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Bernard Côté, Louise Boulet, Christine Brideau, David Claveau, Diane Ethier, André Giroux

Bioorg Med Chem Lett· December 2007

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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.
Elise Isabel, Renee Aspiotis, W Cameron Black, John Colucci, Réjean Fortin, André Giroux

Bioorg Med Chem Lett· March 2007

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Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay.
Paul Tawa, Andre Giroux, Erich Grimm, Yongxin Han, Donald W Nicholson

Anal Biochem· March 2006

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Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
Christophe Mellon, Reneé Aspiotis, Cameron W Black, Christopher I Bayly, Erich L Grimm, André Giroux

Bioorg Med Chem Lett· September 2005

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Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
Yongxin Han, André Giroux, John Colucci, Christopher I Bayly, Daniel J Mckay

Bioorg Med Chem Lett· February 2005

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Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Joseph W Becker, Jennifer Rotonda, Stephen M Soisson, Renee Aspiotis, Christopher Bayly, Andre Giroux

J Med Chem· May 2004

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Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Yongxin Han, André Giroux, Erich L Grimm, Renée Aspiotis, Sébastien Francoeur

Bioorg Med Chem Lett· February 2004

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Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease.
Sylvie Toulmond, Keith Tang, Yves Bureau, Helen Ashdown, Sarah Degen, André Giroux

Br J Pharmacol· February 2004

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Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.
Byung Hee Han, Daigen Xu, Junjeong Choi, Yongxin Han, Steven Xanthoudakis, Andre Giroux

J Biol Chem· August 2002

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Palladium-Catalyzed Suzuki-Type Cross-Couplings of Iodocyclopropanes with Boronic Acids: Synthesis of trans-1,2-Dicyclopropyl Alkenes.
André B. Charette, André Giroux

J Org Chem· December 1996

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