Publications by authors named "Patsy Clark"

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Jason D Burch, Julie Farand, John Colucci, Claudio Sturino, Yves Ducharme, Patsy Clark

Bioorg Med Chem Lett· February 2011

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A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.
Michael J Boyd, Carl Berthelette, Jean-François Chiasson, Patsy Clark, John Colucci

Bioorg Med Chem Lett· January 2011

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The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Marc Blouin, Yongxin Han, Jason Burch, Julie Farand, Christophe Mellon, Patsy Clark

J Med Chem· March 2010

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Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis.
Leigh A Jania, Subhashini Chandrasekharan, Michael G Backlund, Nicholas A Foley, John Snouwaert, Patsy Clark

Prostaglandins Other Lipid Mediat· April 2009

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MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
Daigen Xu, Steven E Rowland, Patsy Clark, André Giroux, Bernard Côté

J Pharmacol Exp Ther· September 2008

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Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.
Marie-Claude Mathieu, Simon Lord-Dufour, Virginie Bernier, Yves Boie, Jason D Burch, Patsy Clark

Eur J Immunol· July 2008

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MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
Patsy Clark, Steven E Rowland, Danielle Denis, Marie-Claude Mathieu, Rino Stocco

J Pharmacol Exp Ther· May 2008

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Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis.
Mei Chen, Eric Boilard, Peter A Nigrovic, Patsy Clark, Daigen Xu

Arthritis Rheum· May 2008

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Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Masako Nakanishi, David C Montrose, Patsy Clark, Prashant R Nambiar, Glenn S Belinsky

Cancer Res· May 2008

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.
Jason D Burch, Michel Belley, Réjean Fortin, Denis Deschênes, Mario Girard, Patsy Clark

Bioorg Med Chem Lett· March 2008

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Simultaneous analysis of prostanoids using liquid chromatography/high-field asymmetric waveform ion mobility spectrometry/tandem mass spectrometry.
James Kapron, Jin Wu, Timo Mauriala, Patsy Clark, Randy W Purves

Rapid Commun Mass Spectrom· July 2007

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Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species.
Steven E Rowland, Patsy Clark, Robert Gordon, Anne K Mullen, Jocelyne Guay

Eur J Pharmacol· April 2007

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Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis.
Anne-Marie Pulichino, Steve Rowland, Tom Wu, Patsy Clark, Daigen Xu

J Pharmacol Exp Ther· December 2006

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Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland.
Subhashini Chandrasekharan, Nicholas A Foley, Leigh Jania, Patsy Clark, Laurent P Audoly

J Lipid Res· December 2005

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Rescue of defective branching nephrogenesis in renal-coloboma syndrome by the caspase inhibitor, Z-VAD-fmk.
Patsy Clark, Alison Dziarmaga, Michael Eccles, Paul Goodyer

J Am Soc Nephrol· February 2004

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Ureteric bud apoptosis and renal hypoplasia in transgenic PAX2-Bax fetal mice mimics the renal-coloboma syndrome.
Alison Dziarmaga, Patsy Clark, Cherie Stayner, Jean Pierre Julien, Elena Torban

J Am Soc Nephrol· November 2003

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