Publications by authors named "Danielle Denis"

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Jason D Burch, Julie Farand, John Colucci, Claudio Sturino, Yves Ducharme, Danielle Denis

Bioorg Med Chem Lett· February 2011

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Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist.
Francois G Gervais, Nicole Sawyer, Rino Stocco, Martine Hamel, Connie Krawczyk, Danielle Denis

Mol Pharmacol· January 2011

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Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Michel Gallant, Christian Beaulieu, Carl Berthelette, John Colucci, Michael A Crackower, Danielle Denis

Bioorg Med Chem Lett· January 2011

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A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.
Michael J Boyd, Carl Berthelette, Jean-François Chiasson, Patsy Clark, John Colucci, Danielle Denis

Bioorg Med Chem Lett· January 2011

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The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.
Lianhai Li, Marie-Claude Mathieu, Danielle Denis, Alex G Therien, Zhaoyin Wang

Bioorg Med Chem Lett· January 2011

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Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.
Lianhai Li, Christian Beaulieu, Marie-Claude Carriere, Danielle Denis, Gillian Greig

Bioorg Med Chem Lett· December 2010

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Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
John Colucci, Michael Boyd, Carl Berthelette, Jean-Francois Chiasson, Zhaoyin Wang, Danielle Denis

Bioorg Med Chem Lett· June 2010

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The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Marc Blouin, Yongxin Han, Jason Burch, Julie Farand, Christophe Mellon, Danielle Denis

J Med Chem· March 2010

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Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
Yves Leblanc, Patrick Roy, Claude Dufresne, Nicolas Lachance, Zhaoyin Wang, Danielle Denis

Bioorg Med Chem Lett· April 2009

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Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.
Marie-Claude Mathieu, Simon Lord-Dufour, Virginie Bernier, Yves Boie, Jason D Burch, Danielle Denis

Eur J Immunol· July 2008

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MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
Patsy Clark, Steven E Rowland, Danielle Denis, Marie-Claude Mathieu, Rino Stocco

J Pharmacol Exp Ther· May 2008

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Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.
Christian Beaulieu, Daniel Guay, Zhaoyin Wang, Yves Leblanc, Patrick Roy, Danielle Denis

Bioorg Med Chem Lett· April 2008

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.
Jason D Burch, Michel Belley, Réjean Fortin, Denis Deschênes, Mario Girard, Danielle Denis

Bioorg Med Chem Lett· March 2008

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Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
Claudio F Sturino, Gary O'Neill, Nicolas Lachance, Michael Boyd, Carl Berthelette, Danielle Denis

J Med Chem· February 2007

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Comparison between two classes of selective EP(3) antagonists and their biological activities.
Michel Belley, Chi Chung Chan, Yves Gareau, Michel Gallant, Hélène Juteau, Danielle Denis

Bioorg Med Chem Lett· November 2006

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Identification of an indole series of prostaglandin D2 receptor antagonists.
Claudio F Sturino, Nicolas Lachance, Michael Boyd, Carl Berthelette, Marc Labelle, Danielle Denis

Bioorg Med Chem Lett· June 2006

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Identification of a potent and selective synthetic agonist at the CRTH2 receptor.
François G Gervais, Jean-Pierre Morello, Christian Beaulieu, Nicole Sawyer, Danielle Denis

Mol Pharmacol· June 2005

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Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.
Michel Belley, Michel Gallant, Bruno Roy, Karine Houde, Nicolas Lachance, Danielle Denis

Bioorg Med Chem Lett· February 2005

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2,3-Diarylthiophenes as selective EP1 receptor antagonists.
Yves Ducharme, Marc Blouin, Marie-Claude Carrière, Anne Chateauneuf, Bernard Côté, Danielle Denis

Bioorg Med Chem Lett· February 2005

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Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis.
Christian Beaulieu, Zhaoyin Wang, Danielle Denis, Gillian Greig, Sonia Lamontagne

Bioorg Med Chem Lett· June 2004

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Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor.
Michel Gallant, Michel Belley, Marie-Claude Carrière, Anne Chateauneuf, Danielle Denis

Bioorg Med Chem Lett· November 2003

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Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
Xavier Billot, Anne Chateauneuf, Nathalie Chauret, Danielle Denis, Gillian Greig

Bioorg Med Chem Lett· March 2003

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The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat.
James G Martin, Masaru Suzuki, Karim Maghni, Rosa Pantano, David Ramos-Barbón, Danielle Denis

J Immunol· October 2002

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