Publications by authors named "Jason Burch"

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Discovery of novel NLRP3 inhibitors enabled by a high-throughput screen.
Stéphane Dorich, Anick Auger, Li Wang, Jason Burch, Charles Pellerin

Bioorg Med Chem Lett· July 2025

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Structural insight into the cGAS active site explains differences between therapeutically relevant species.
Alexander M Skeldon, Li Wang, Nicolas Sgarioto, Ramsay E Beveridge, Silas Chan, Jason D Burch

Commun Chem· March 2025

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Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization.
Patrick Cyr, Lee D Fader, Jason D Burch, Kelly A Pike, Daniel V Sietsema

ACS Med Chem Lett· December 2024

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Depicting and defining sleep disturbed breathing associated with vagal nerve stimulation.
Ashley L Garrett, Jason Burch, Yue Zhang, Haojia Li, Krishna M Sundar

Sleep Med· October 2023

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Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease.
Miguel St-Onge, Amandine Chefson, Joyce Wu, Édouard Caron-Duval, Valerie Dumais, Jason Burch

Bioorg Med Chem Lett· July 2023

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Total Synthesis of Aflastatin A.
David A Evans, Jason J Beiger, Jason D Burch, Peter H Fuller, Frank Glorius

J Am Chem Soc· November 2022

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Could AlphaFold revolutionize chemical therapeutics?
Alexander B Tong, Jason D Burch, Daniel McKay, Carlos Bustamante, Michael A Crackower

Nat Struct Mol Biol· October 2021

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Novel pyridone EP agonists featuring allylic alcohol ω-chains.
Stéphane Dorich, Jennifer H Cox, Jason D Burch, Félix Chagnon, Bin Chen

Bioorg Med Chem Lett· May 2020

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Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3-Alkylbicyclo[1.1.1]pentan-1-amines.
Jonathan M E Hughes, David A Scarlata, Austin C-Y Chen, Jason D Burch, James L Gleason

Org Lett· September 2019

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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
Nicole Blaquiere, Georgette M Castanedo, Jason D Burch, Leonid M Berezhkovskiy, Hans Brightbill

J Med Chem· August 2018

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Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal Growth in Candida albicans.
Jason M Burch, Siavash Mashayekh, Dennis D Wykoff, Catherine L Grimes

ACS Infect Dis· January 2018

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Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70.
Amy K Schaefer, Hannah C Wastyk, Vishnu Mohanan, Ching-Wen Hou, Mackenzie L Lauro, Jason M Burch

Biochemistry· August 2017

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The effect of NOD2 on the microbiota in Crohn's disease.
Mackenzie L Lauro, Jason M Burch, Catherine Leimkuhler Grimes

Curr Opin Biotechnol· August 2016

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Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors.
Alexander Heifetz, Giancarlo Trani, Matteo Aldeghi, Colin H MacKinnon, Paul A McEwan, Jason D Burch

J Med Chem· May 2016

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Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Yonglian Sun, Ivan Peng, Joshua D Webster, Eric Suto, Justin Lesch, Jason D Burch

Sci Signal· December 2015

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Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
Jason D Burch, Kathy Barrett, Yuan Chen, Jason DeVoss, Charles Eigenbrot

J Med Chem· May 2015

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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).
Giancarlo Trani, John J Barker, Steven M Bromidge, Frederick A Brookfield, Jason D Burch

Bioorg Med Chem Lett· December 2014

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In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor.
Ming-Tain Lai, Meizhen Feng, Jean-Pierre Falgueyret, Paul Tawa, Marc Witmer, Jason Burch

Antimicrob Agents Chemother· October 2014

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Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.
Jason D Burch, Kevin Lau, John J Barker, Fred Brookfield, Yong Chen

J Med Chem· July 2014

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Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
Richard M Pastor, Jason D Burch, Steven Magnuson, Daniel F Ortwine, Yuan Chen

Bioorg Med Chem Lett· June 2014

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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Bernard Côté, Jason D Burch, Ernest Asante-Appiah, Chris Bayly, Leanne Bédard

Bioorg Med Chem Lett· February 2014

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Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.
Steven T Staben, Jianwen A Feng, Karen Lyle, Marcia Belvin, Jason Boggs, Jason D Burch

J Med Chem· February 2014

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Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK).
Colin H MacKinnon, Kevin Lau, Jason D Burch, Yuan Chen, Jonathon Dines

Bioorg Med Chem Lett· December 2013

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Jason D Burch, Julie Farand, John Colucci, Claudio Sturino, Yves Ducharme

Bioorg Med Chem Lett· February 2011

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The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Marc Blouin, Yongxin Han, Jason Burch, Julie Farand, Christophe Mellon

J Med Chem· March 2010

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