Publications by authors named "Amandine Chefson"

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Discovery of novel NLRP3 inhibitors enabled by a high-throughput screen.
Stéphane Dorich, Anick Auger, Li Wang, Jason Burch, Charles Pellerin, Amandine Chefson

Bioorg Med Chem Lett· July 2025

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Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration.
Anick Auger, Rania Faidi, Alexis D Rickman, Carolina Pena Martinez, Austin Fajfer, Amandine Chefson

NPJ Dement· May 2025

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Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).
W Cameron Black, Abbas Abdoli, Xiuli An, Anick Auger, Patrick Beaulieu, Amandine Chefson

J Med Chem· February 2024

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Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease.
Miguel St-Onge, Amandine Chefson, Joyce Wu, Édouard Caron-Duval, Valerie Dumais

Bioorg Med Chem Lett· July 2023

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Identification of , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Amandine Chefson

J Med Chem· October 2022

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RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.
Anne Roulston, Michal Zimmermann, Robert Papp, Alexander Skeldon, Charles Pellerin, Amandine Chefson

Mol Cancer Ther· February 2022

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Stability of Hydrocortisone, Nifedipine, and Nitroglycerine Compounded Preparations for the Treatment of Anorectal Conditions.
Mihaela Friciu, Amandine Chefson, Grégoire Leclair

Can J Hosp Pharm· September 2016

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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Bernard Côté, Jason D Burch, Ernest Asante-Appiah, Chris Bayly, Leanne Bédard, Amandine Chefson

Bioorg Med Chem Lett· February 2014

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Design and synthesis of potent, isoxazole-containing renin inhibitors.
Pierre-André Fournier, Mélissa Arbour, Elizabeth Cauchon, Austin Chen, Amandine Chefson

Bioorg Med Chem Lett· April 2012

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Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.
Jean-François Lévesque, Kelly Bleasby, Amandine Chefson, Austin Chen, Daniel Dubé

Bioorg Med Chem Lett· September 2011

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Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.
Austin Chen, Louis-Charles Campeau, Elizabeth Cauchon, Amandine Chefson, Yves Ducharme

Bioorg Med Chem Lett· July 2011

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Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.
Austin Chen, Elizabeth Cauchon, Amandine Chefson, Sarah Dolman, Yves Ducharme

Bioorg Med Chem Lett· July 2011

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CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents.
Amandine Chefson, Karine Auclair

Chembiochem· July 2007

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Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6.
Amandine Chefson, Jin Zhao, Karine Auclair

J Biotechnol· July 2007

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Progress towards the easier use of P450 enzymes.
Amandine Chefson, Karine Auclair

Mol Biosyst· October 2006

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Replacement of natural cofactors by selected hydrogen peroxide donors or organic peroxides results in improved activity for CYP3A4 and CYP2D6.
Amandine Chefson, Jin Zhao, Karine Auclair

Chembiochem· June 2006

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