Publications by authors named "Daniel Dube"

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Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine.
Gilbert Stork, Ayako Yamashita, Robert M Hanson, Ly Phan, Eifion Phillips

Org Lett· October 2017

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3,4-Diarylpiperidines as potent renin inhibitors.
Patrick Lacombe, Mélissa Arbour, Renée Aspiotis, Elizabeth Cauchon, Austin Chen

Bioorg Med Chem Lett· March 2012

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Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.
Jean-François Lévesque, Kelly Bleasby, Amandine Chefson, Austin Chen, Daniel Dubé

Bioorg Med Chem Lett· September 2011

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Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.
Austin Chen, Louis-Charles Campeau, Elizabeth Cauchon, Amandine Chefson, Yves Ducharme

Bioorg Med Chem Lett· July 2011

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Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.
Austin Chen, Elizabeth Cauchon, Amandine Chefson, Sarah Dolman, Yves Ducharme

Bioorg Med Chem Lett· July 2011

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The discovery and synthesis of potent zwitterionic inhibitors of renin.
Renee Aspiotis, Austin Chen, Elizabeth Cauchon, Daniel Dubé, Jean-Pierre Falgueyret

Bioorg Med Chem Lett· April 2011

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Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.
Michel Gallant, Renee Aspiotis, Stephen Day, Rebecca Dias, Daniel Dubé

Bioorg Med Chem Lett· November 2010

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Identification of a new biaryl scaffold generating potent renin inhibitors.
Patrick Lacombe, Renée Aspiotis, Christopher Bayly, Austin Chen, Daniel Dubé

Bioorg Med Chem Lett· October 2010

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Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study.
Austin Chen, Daniel Dubé, Laurence Dubé, Sébastien Gagné, Michel Gallant

Bioorg Med Chem Lett· September 2010

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The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.
Renee Aspiotis, Denis Deschênes, Daniel Dubé, Yves Girard, Zheng Huang

Bioorg Med Chem Lett· September 2010

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Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.
Austin Chen, Christopher Bayly, Olivier Bezençon, Sylvia Richard-Bildstein, Daniel Dubé

Bioorg Med Chem Lett· April 2010

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Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Patrick Lacombe, Nathalie Chauret, David Claveau, Stephen Day, Denis Deschênes

Bioorg Med Chem Lett· September 2009

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Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.
Michel Gallant, Nathalie Chauret, David Claveau, Stephen Day, Denis Deschênes

Bioorg Med Chem Lett· February 2008

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Evaluation of the causes of racial disparity in surgical treatment of early-stage lung cancer.
Daniel S Dube

Chest· October 2006

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Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.
Kevin P Bateman, Laird Trimble, Nathalie Chauret, Jose Silva, Stephen Day, Daniel Dube

J Mass Spectrom· June 2006

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Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.
Patrick Lacombe, Denis Deschênes, Daniel Dubé, Laurence Dubé, Michel Gallant

Bioorg Med Chem Lett· May 2006

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Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
Dwight Macdonald, Anthony Mastracchio, Hélène Perrier, Daniel Dubé, Michel Gallant

Bioorg Med Chem Lett· December 2005

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The Diabetes Prevention Program and the metabolic syndrome.
Priscilla S Sarinas, Daniel S Dube

Ann Intern Med· October 2005

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Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors.
Susana Liu, Alain Veilleux, Lei Zhang, Andrew Young, Evonne Kwok

J Pharmacol Exp Ther· August 2005

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A trial of intrapleural streptokinase.
Chandra K Katikireddy, Daniel S Dube

N Engl J Med· May 2005

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Influence of overweight on ICU mortality: a prospective study.
Daniel S Dube

Chest· February 2005

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The dropped head sign: an unusual presenting feature of myasthenia gravis.
Michael Puruckherr, Payam Pooyan, Daniel Dube, Ryland P Byrd, Thomas M Roy

Neuromuscul Disord· June 2004

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Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones.
Qingping Wang, Daniel Dubé, Richard W Friesen, Tammy G LeRiche, Kevin P Bateman

Biochemistry· April 2004

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Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors.
Yves Ducharme, Richard W Friesen, Marc Blouin, Bernard Côté, Daniel Dubé

Bioorg Med Chem Lett· June 2003

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A lesson in poverty.
Daniel Sijipunda Dube

Ann Intern Med· June 2003

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