Publications by authors named "Laird Trimble"

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Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib.
Robert Papp, Laird Trimble, Adrian J Fretland, Ravi Manohar, Richard Phipps

Drug Metab Dispos· February 2024

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Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection.
Lin Xu, Bruce Adams, Valentina V Jeliazkova-Mecheva, Laird Trimble, Gloria Kwei

Drug Metab Dispos· April 2008

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Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: impacts of glutathione trapping and glucuronide conjugation on covalent binding.
Jean-François Lévesque, Stephen H Day, Nathalie Chauret, Carmai Seto, Laird Trimble

Bioorg Med Chem Lett· June 2007

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Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
Claudio F Sturino, Gary O'Neill, Nicolas Lachance, Michael Boyd, Carl Berthelette, Laird A Trimble

J Med Chem· February 2007

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In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites.
Deborah A Nicoll-Griffith, Carmai Seto, Yves Aubin, Jean François Lévesque, Nathalie Chauret, Laird A Trimble

Bioorg Med Chem Lett· January 2007

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Isolation and structure elucidation by LC-MS-SPE/NMR: PR toxin- and cuspidatol-related eremophilane sesquiterpenes from Penicillium roqueforti.
Dan Sørensen, Annie Raditsis, Laird A Trimble, Barbara A Blackwell, Mark W Sumarah

J Nat Prod· January 2007

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Total synthesis of (+)-cyanthiwigin AC.
T Jagadeeswar Reddy, Guillaume Bordeau, Laird Trimble

Org Lett· November 2006

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Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.
Kevin P Bateman, Laird Trimble, Nathalie Chauret, Jose Silva, Stephen Day

J Mass Spectrom· June 2006

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Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
Dwight Macdonald, Anthony Mastracchio, Hélène Perrier, Daniel Dubé, Michel Gallant, Laird A Trimble

Bioorg Med Chem Lett· December 2005

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Discovery, biosynthesis, and structure elucidation of metabolites of a doping agent and a direct analogue, tetrahydrogestrinone and gestrinone, using human hepatocytes.
Jean-François Lévesque, Erin Templeton, Laird Trimble, Carl Berthelette, Nathalie Chauret

Anal Chem· May 2005

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Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.
Michel Belley, Michel Gallant, Bruno Roy, Karine Houde, Nicolas Lachance, Laird A Trimble

Bioorg Med Chem Lett· February 2005

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Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones.
Qingping Wang, Daniel Dubé, Richard W Friesen, Tammy G LeRiche, Kevin P Bateman, Laird Trimble

Biochemistry· April 2004

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Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
F Peter Guengerich, Grover P Miller, Imad H Hanna, Martha V Martin, Serge Léger, Laird A Trimble

Biochemistry· September 2002

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Studies on the Dimerization of 2-Benzylidene-1-indanone.
Carl Berthelette, Chris McCooye, Yves Leblanc, Laird A. Trimble, Nancy N. Tsou

J Org Chem· June 1997

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