Publications by authors named "Yongxin Han"

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AKAP1-STABILIZED TIMP-4 ATTENUATES ANG-II-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN VASCULAR SMOOTH MUSCLE CELLS BY INACTIVATING THE NF-ΚB SIGNALING.
Yongxin Han, Xuejun Wu, Xin Shi, Guoliang Zhang, Xiaohan Wang

Shock· May 2025

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MCPIP1 deficiency alleviates abdominal aortic aneurysm formation by inhibiting MAPK signaling.
Ming Xue, Hailing Ding, Yongxin Han, Yuhua Wei, Xuming Wang, Xiaohan Wang

Biochem Cell Biol· January 2025

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Machine Learning ADME Models in Practice: Four Guidelines from a Successful Lead Optimization Case Study.
Alexander S Rich, Yvonne H Chan, Benjamin Birnbaum, Kamran Haider, Joshua Haimson, Yongxin Han

ACS Med Chem Lett· August 2024

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The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Yongxin Han

Cancer Discov· July 2024

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Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS Inhibitor.
Xiaoshen Ma, David L Sloman, Ruchia Duggal, Kenneth D Anderson, Jeanine E Ballard, Indu Bharathan, David Jonathan Bennett, Yongxin Han

J Med Chem· July 2024

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Hyperlactatemia in patients undergoing pulmonary endarterectomy with deep hypothermic circulatory arrest: Risk factors and its effects on the outcome.
Ying-Hui Fang, Ya-Jun Zhang, Ya-Nan Zhen, Xiao-Peng Liu, Guang Sun, Yong-Xin Han

Perfusion· November 2023

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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
Michael T Rudd, Peter J Manley, Barbara Hanney, Zhaoyang Meng, Youheng Shu, Yongxin Han, Neetesh Bhandari, Jonathan T Kern

ACS Med Chem Lett· August 2023

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[Risk factors of hyperlactatemia during pulmonary endarterectomy under deep hypothermic circulatory arrest and its influence on prognosis].
Y H Fang, Y J Zhang, X P Zhen, G Liu, Y X Sun, Yongxin Han

Zhonghua Yi Xue Za Zhi· January 2023

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Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
Derun Li, David L Sloman, Abdelghani Achab, Hua Zhou, Meredeth A McGowan, Hongjun Zhang, Indu Bharathan, Huangguang Zhang, David Jonathan Bennett, Yongxin Han

J Med Chem· April 2022

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WNT5B promotes vascular smooth muscle cell dedifferentiation via mitochondrial dynamics regulation in chronic thromboembolic pulmonary hypertension.
Feng Wang, Yanan Zhen, Chaozeng Si, Cheng Wang, Lin Pan, Yongxin Han

J Cell Physiol· January 2022

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Role of pyroptosis in atherosclerosis and its therapeutic implications.
Bin He, Qiangqiang Nie, Feng Wang, Yongxin Han, Bo Yang

J Cell Physiol· October 2021

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Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold.
Wensheng Yu, Yongqi Deng, David Sloman, Derun Li, Kun Liu, David Jonathan Bennett, Yongxin Han

Bioorg Med Chem Lett· October 2021

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SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors.
Wensheng Yu, Yongqi Deng, Brett Hopkins, Xianhai Huang, David Sloman, Hongjun Zhang, David Jonathan Bennett, Yongxin Han

Bioorg Med Chem Lett· September 2021

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Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors.
Brett Hopkins, Hongjun Zhang, Indu Bharathan, Derun Li, Qinglin Pu, David Jonathan Bennett, Yongxin Han

ACS Med Chem Lett· September 2021

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Surgical treatment of primary pulmonary artery sarcoma.
Yongxin Han, Yanan Zhen, Xiaopeng Liu, Xia Zheng, Jianbin Zhang, Yajun Zhang

Gen Thorac Cardiovasc Surg· April 2021

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Carbamate and -Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.
Derun Li, Yongqi Deng, Abdelghani Achab, Indu Bharathan, Brett Andrew Hopkins, Hongjun Zhang, David Jonathan Bennett, Yongxin Han

ACS Med Chem Lett· March 2021

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Combination of EP antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells.
Yun Wang, Long Cui, Peter Georgiev, Latika Singh, Yanyan Zheng, Chunsheng Zhang, Yongxin Han

Oncoimmunology· March 2021

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Selective Synthesis of 1-Dialkylamino-2-alkylbicyclo-[1.1.1]pentanes.
Xiaoshen Ma, Yongxin Han, David J Bennett

Org Lett· November 2020

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Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors.
Qinglin Pu, Hongjun Zhang, Liangqin Guo, Mangeng Cheng, Amy C Doty, David Jonathan Bennett, Yongxin Han

ACS Med Chem Lett· August 2020

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Small Molecular Immune Modulators as Anticancer Agents.
Yongxin Han, Li Zhu, Wei Wu, Hui Zhang, Wei Hu

Adv Exp Med Biol· April 2020

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Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1).
Catherine White, Meredeth A McGowan, Hua Zhou, Nunzio Sciammetta, Xavier Fradera, David Jonathan Bennett, Yongxin Han

ACS Med Chem Lett· April 2020

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Impact of pulmonary thromboendarterectomy on tricuspid regurgitation in patients with chronic thromboembolic pulmonary hypertension: a single-center prospective cohort experience.
Yanan Zhen, Jianbin Zhang, Xiaopeng Liu, Guang Sun, Xia Zheng, Yongxin Han

J Thorac Dis· March 2020

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Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.
Hongjun Zhang, Kun Liu, Qinglin Pu, Abdelghani Achab, Michael J Ardolino, David Jonathan Bennett, Yongxin Han

ACS Med Chem Lett· November 2019

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A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: "BCP-F".
Xiaoshen Ma, David L Sloman, Yongxin Han, David J Bennett

Org Lett· September 2019

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An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review.
XiaoYu Fan, WenYue Wang, ChaoFeng Li, Tao Tang, YongXin Han

Medicine (Baltimore)· April 2019

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