Publications by authors named "Meagan B Ryan"

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The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg

Cancer Discov· July 2024

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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression.
Ioannis Sanidas, Hanjun Lee, Purva H Rumde, Gaylor Boulay, Robert Morris, Meagan B Ryan, Ryan B Corcoran

Mol Cell· September 2022

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KRAS-independent feedback activation of wild-type RAS constrains KRAS inhibitor efficacy.
Meagan B Ryan, Oluwadara Coker, Alexey Sorokin, Katerina Fella, Haley Barnes, Ryan B Corcoran

Cell Rep· June 2022

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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment.
Jennifer E Klomp, Ye S Lee, Craig M Goodwin, Björn Papke, Jeff A Klomp, Meagan B Ryan, Kirsten L Bryant

Cell Rep· November 2021

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Clinical Acquired Resistance to KRAS Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation.
Noritaka Tanaka, Jessica J Lin, Chendi Li, Meagan B Ryan, Junbing Zhang, Ryan B Corcoran

Cancer Discov· August 2021

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Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRAS Inhibition.
Meagan B Ryan, Ferran Fece de la Cruz, Sarah Phat, David T Myers, Edmond Wong, Ryan B Corcoran

Clin Cancer Res· April 2020

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WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.
Megan J Agajanian, Matthew P Walker, Alison D Axtman, Roberta R Ruela-de-Sousa, D Stephen Serafin, Meagan B Ryan

Cell Rep· January 2019

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Therapeutic strategies to target RAS-mutant cancers.
Meagan B Ryan, Ryan B Corcoran

Nat Rev Clin Oncol· November 2018

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ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma.
Meagan B Ryan, Alexander J Finn, Katherine H Pedone, Nancy E Thomas, Channing J Der

Mol Cancer Res· October 2016

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Targeting -mutant cancers: is ERK the key?
Meagan B Ryan, Channing J Der, Andrea Wang-Gillam, Adrienne D Cox

Trends Cancer· November 2015

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