Publications by authors named "Alison D Axtman"

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BRSK2 plays a role in autophagy and cancer cell growth and survival under nutrient deprivation stress via the PIK3C3 pathway.
Aparna Maiti, Alison D Axtman, Rongrong Wu, Lydia J B Redman, Kazuaki Takabe

Sci Rep· November 2025

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Cellular Selectivity Analyses Reveal Distinguishing Profiles for Type II Kinase Inhibitors.
Matthew J Binder, Frances M Bashore, Kaitlin K Dunn Hoffman, Cameron Daamgard, Michael R Slater, Alison D Axtman

bioRxiv· October 2025

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Development of a chemical probe to enable characterization of the casein kinase 1γ subfamily.
Jacob L Capener, Thomas W Kramer, Frances M Bashore, Emily Flory, Fengling Li, Alison D Axtman

bioRxiv· September 2025

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Development of a Second-Generation, Chemical Probe for PIKfyve.
Sophia M Min, Frances M Bashore, Jeffery L Smith, Tammy M Havener, Stefanie Howell, Alison D Axtman

J Med Chem· February 2025

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Targeting Na1.7 and Na1.8 with a PIKfyve inhibitor to reverse inflammatory and neuropathic pain.
Erick J Rodríguez-Palma, Santiago Loya-Lopez, Sophia M Min, Aida Calderon-Rivera, Kimberly Gomez, Alison D Axtman

Neurobiol Pain· November 2024

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Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2.
Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Alison D Axtman

Molecules· September 2024

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Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Alison D Axtman

ACS Med Chem Lett· August 2024

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More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication.
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Alison D Axtman

J Med Chem· July 2024

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Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.
Jacob L Capener, James D Vasta, Vittorio L Katis, Ani Michaud, Michael T Beck, Alison D Axtman

bioRxiv· June 2024

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Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships.
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Alison D Axtman

Eur J Med Chem· May 2024

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Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Alison D Axtman

bioRxiv· May 2024

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Illuminating function of the understudied druggable kinome.
Shawn M Gomez, Alison D Axtman, Timothy M Willson, Michael B Major, Reid R Townsend

Drug Discov Today· March 2024

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Illumination of understudied ciliary kinases.
Raymond G Flax, Peter Rosston, Cecilia Rocha, Brian Anderson, Jacob L Capener, Alison D Axtman

Front Mol Biosci· March 2024

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, Alison D Axtman

PLoS One· February 2024

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Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity.
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Alison D Axtman

Pharmaceuticals (Basel)· February 2024

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Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Yuhong Du, William J Bradshaw, Tina M Leisner, Joel K Annor-Gyamfi, Kun Qian, Alison D Axtman

J Biol Chem· December 2023

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Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships.
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Alison D Axtman

bioRxiv· December 2023

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Fused Tetrahydroquinolines Are Interfering with Your Assay.
Frances M Bashore, Joel Annor-Gyamfi, Yuhong Du, Vittorio Katis, Felix Nwogbo, Alison D Axtman

J Med Chem· November 2023

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Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A.
Xuan Yang, Han Wee Ong, Rebekah J Dickmander, Jeffery L Smith, Jason W Brown, Alison D Axtman

ACS Omega· October 2023

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Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A.
Xuan Yang, Han Wee Ong, Rebekah J Dickmander, Jeffery L Smith, Jason W Brown, Alison D Axtman

bioRxiv· July 2023

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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Anna Castano, Margaux Silvestre, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Alison D Axtman

Elife· July 2023

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, Alison D Axtman

bioRxiv· July 2023

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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Anna Castano, Margaux Silvestre, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Alison D Axtman

bioRxiv· June 2023

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Open drug discovery in Alzheimer's disease.
Alison D Axtman, Paul E Brennan, Tristan Frappier-Brinton, Ranjita Betarbet, Gregory W Carter

Alzheimers Dement (N Y)· May 2023

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Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease.
Yuhong Du, William J Bradshaw, Tina M Leisner, Joel K Annor-Gyamfi, Kun Qian, Alison D Axtman

bioRxiv· May 2023

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