Publications by authors named "Michael B Major"

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Activating NRF2 mutation alters the differentiation of human non-small cell lung cancer.
Samera H Hamad, Hansa Joshi, T Hess, Stuart R Jefferys, Zena Saleh, Michael B Major

Cancer Gene Ther· December 2025

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A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth.
Nilotpal Roy, Tine Wyseure, I-Chung Lo, Justine Lu, Christie L Eissler, Michael B Major

Cancer Discov· December 2025

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Pyrimethamine and a potent analog inhibit NRF2 by suppressing one-carbon metabolism.
Julius Chembo, Brittany M Bowman, Kyle Lapak, Emily Wilkerson, Nathan T Wamsley, Michael B Major

J Biol Chem· October 2025

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NRF2 immunobiology in cancer: implications for immunotherapy and therapeutic targeting.
Harit Panda, Natalie G Rowland, Caroline M Krall, Brittany M Bowman, Michael B Major

Oncogene· October 2025

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Mapping of the hSOX10 protein interactome in human melanoma.
Catherine M Newsom-Stewart, Dhaval P Bhatt, Michael B Major, Charles K Kaufman

bioRxiv· September 2025

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Stable Cas9 expression regulates cell growth by facilitating mTORC2 activation.
Le Yu, Yi Jin, Jianfeng Chen, Zhichuan Zhu, Siyuan Su, Michael B Major

Nucleic Acids Res· September 2025

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A SETD2-CDK1-lamin axis maintains nuclear morphology and genome stability.
Abid Khan, Cheng Zhang, Phu G Nguyen, James M Metts, Lucas C Collins, Michael B Major

Nat Cell Biol· August 2025

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Association between Locoregional Failure and NFE2L2/KEAP1/CUL3 Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer.
Li Guan, Pedro A Torres-Saavedra, Xiaobei Zhao, Michael B Major, Brittany J Holmes

Clin Cancer Res· May 2025

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The contribution of de novo coding mutations to meningomyelocele.
Yoo-Jin Jiny Ha, Ashna Nisal, Isaac Tang, Chanjae Lee, Ishani Jhamb, Michael B Major

Nature· May 2025

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The gain-of-function UBE3A variant causes Angelman-like neurodevelopmental phenotypes in mice.
Kellan P Weston, Anna M Gunelson, Susan E Maloney, Xia Ge, Jalin A Stelzer, Michael B Major

Sci Rep· March 2025

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Proximity proteomics provides a new resource for exploring the function of Afadin and the complexity of cell-cell adherens junctions.
Wangsun Choi, Dennis Goldfarb, Feng Yan, Michael B Major, Alan S Fanning

Biol Open· February 2025

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Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism.
Julius Chembo, Brittany M Bowman, Kyle Lapak, Emily Wilkerson, Chorlada Paiboonrungruang, Michael B Major

bioRxiv· February 2025

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Author Correction: A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.
Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M Greenwalt, Dennis Goldfarb, Feng Yan, Michael B Major

Nat Commun· November 2024

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Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency.
Jianfeng Chen, Siyuan Su, Adrian Pickar-Oliver, Anna M Chiarella, Quentin Hahn, Michael B Major

Nucleic Acids Res· October 2024

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A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
Maritza Puray-Chavez, Jenna E Eschbach, Ming Xia, Kyle M LaPak, Qianzi Zhou, Michael B Major

bioRxiv· September 2024

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Mutant Nrf2 enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors.
John G Witherspoon, Jonathan R Hall, Dereje Jima, Hannah M Atkins, Nathan T Wamsley, Michael B Major

Redox Biol· September 2024

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The small MAF transcription factor MAFG co-opts MITF to promote melanoma progression.
Olga Vera, Michael Martinez, Zulaida Soto-Vargas, Kaizhen Wang, Xiaonan Xu, Michael B Major

bioRxiv· September 2024

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A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
Maritza Puray-Chavez, Jenna E Eschbach, Ming Xia, Kyle M LaPak, Qianzi Zhou, Michael B Major

Nat Commun· September 2024

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Transcriptional analysis of primary ciliary dyskinesia airway cells reveals a dedicated cilia glutathione pathway.
Jeffrey R Koenitzer, Deepesh Kumar Gupta, Wang Kyaw Twan, Huihui Xu, Nicholas Hadas, Michael B Major

JCI Insight· July 2024

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TCAF1 promotes TRPV2-mediated Ca release in response to cytosolic DNA to protect stressed replication forks.
Lingzhen Kong, Chen Cheng, Abigael Cheruiyot, Jiayi Yuan, Yichan Yang, Michael B Major

Nat Commun· May 2024

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Illuminating function of the understudied druggable kinome.
Shawn M Gomez, Alison D Axtman, Timothy M Willson, Michael B Major, Reid R Townsend

Drug Discov Today· March 2024

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NRF2 Activation in Trp53;p16-deficient Mice Drives Oral Squamous Cell Carcinoma.
Samera H Hamad, Rani S Sellers, Nathan Wamsley, Paul Zolkind, Travis P Schrank, Michael B Major

Cancer Res Commun· February 2024

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ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas.
Vinh Nguyen, Travis P Schrank, Michael B Major, Bernard E Weissman

PLoS One· February 2024

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Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
Nathan T Wamsley, Emily M Wilkerson, Li Guan, Kyle M LaPak, Travis P Schrank, Michael B Major

Mol Cell Proteomics· November 2023

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NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells.
Li Guan, Dhanya K Nambiar, Hongbin Cao, Vignesh Viswanathan, Shirley Kwok, Michael B Major

Cancer Res· March 2023

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