Publications by authors named "James D Vasta"

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A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
Elisabeth M Rothweiler, Ani Michaud, Jakub Stefaniak, Usha Singh, Brynwood B Mikulsky, James D Vasta

Nat Commun· December 2025

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Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, James D Vasta

J Med Chem· August 2024

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tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis.
Johannes Dopfer, James D Vasta, Susanne Müller, Stefan Knapp, Matthew B Robers

Nat Commun· July 2024

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Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.
Jacob L Capener, James D Vasta, Vittorio L Katis, Ani Michaud, Michael T Beck

bioRxiv· June 2024

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A Method to Conditionally Measure Target Engagement at Intracellular RAS and RAF Complexes.
James D Vasta, Ani Michaud, J Aaron Crapster, Matthew B Robers

Methods Mol Biol· April 2024

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Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis.
Tatsuo Sugawara, Ekaterina Nevedomskaya, Simon Heller, Annika Böhme, Ralf Lesche, James D Vasta

Mol Oncol· March 2024

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Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex.
James D Vasta, Ani Michaud, Chad A Zimprich, Michael T Beck, Matthew R Swiatnicki

Cell Chem Biol· November 2023

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DELs enable the development of BRET probes for target engagement studies in cells.
Kelly A Teske, Wenji Su, Cesear R Corona, Jing Wen, Jason Deng, James D Vasta

Cell Chem Biol· August 2023

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NanoBRET™ Live-Cell Kinase Selectivity Profiling Adapted for High-Throughput Screening.
Amanda N Nieman, Kaitlin K Dunn Hoffman, Elizabeth R Dominguez, Jennifer Wilkinson, James D Vasta

Methods Mol Biol· August 2023

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells.
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, James D Vasta

bioRxiv· March 2023

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells.
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, James D Vasta

Molecules· March 2023

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Small-molecule inhibition of the archetypal UbiB protein COQ8.
Nathan H Murray, Christopher R M Asquith, Zixiang Fang, Michael P East, Naomi Ptak, James D Vasta

Nat Chem Biol· February 2023

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A High-Throughput Method to Prioritize PROTAC Intracellular Target Engagement and Cell Permeability Using NanoBRET.
James D Vasta, Cesear R Corona, Matthew B Robers

Methods Mol Biol· November 2022

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KRAS is vulnerable to reversible switch-II pocket engagement in cells.
James D Vasta, D Matthew Peacock, Qinheng Zheng, Joel A Walker, Ziyang Zhang

Nat Chem Biol· June 2022

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A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Martin P Schwalm, Lena M Berger, Maximilian N Meuter, James D Vasta, Cesear R Corona

Front Cell Dev Biol· May 2022

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Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Florian Wittlinger, David E Heppner, Ciric To, Marcel Günther, Bo Hee Shin, James D Vasta

J Med Chem· January 2022

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Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET.
Matthew B Robers, Jennifer M Wilkinson, James D Vasta, Lena M Berger, Benedict-Tilman Berger

STAR Protoc· December 2021

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CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle-Dependent Degradation of CDK2.
Kristin M Riching, Marie K Schwinn, James D Vasta, Matthew B Robers, Thomas Machleidt

SLAS Discov· April 2021

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Discovery of a selective inhibitor of doublecortin like kinase 1.
Fleur M Ferguson, Behnam Nabet, Srivatsan Raghavan, Yan Liu, Alan L Leggett, James D Vasta

Nat Chem Biol· June 2020

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Quantifying CDK inhibitor selectivity in live cells.
Carrow I Wells, James D Vasta, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich

Nat Commun· June 2020

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Quantitative, Real-Time Measurements of Intracellular Target Engagement Using Energy Transfer.
Matthew B Robers, James D Vasta, Cesear R Corona, Rachel Friedman Ohana, Robin Hurst

Methods Mol Biol· June 2019

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Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Saleta Vazquez-Rodriguez, Miranda Wright, Catherine M Rogers, Adam P Cribbs, Srikannathasan Velupillai, James D Vasta

Angew Chem Int Ed Engl· January 2019

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Collagen Prolyl 4-Hydroxylase as a Therapeutic Target.
James D Vasta, Ronald T Raines

J Med Chem· December 2018

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Binding Kinetics Survey of the Drugged Kinome.
Victoria Georgi, Felix Schiele, Benedict-Tilman Berger, Andreas Steffen, Paula A Marin Zapata, James D Vasta

J Am Chem Soc· November 2018

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Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action.
Kristin M Riching, Sarah Mahan, Cesear R Corona, Mark McDougall, James D Vasta

ACS Chem Biol· September 2018

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