Publications by authors named "Matthew B Robers"

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A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
Elisabeth M Rothweiler, Ani Michaud, Jakub Stefaniak, Usha Singh, Brynwood B Mikulsky, Matthew B Robers

Nat Commun· December 2025

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Cellular Selectivity Analyses Reveal Distinguishing Profiles for Type II Kinase Inhibitors.
Matthew J Binder, Frances M Bashore, Kaitlin K Dunn Hoffman, Cameron Daamgard, Michael R Slater, Matthew B Robers

bioRxiv· October 2025

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Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays.
Francisco Castillo, Thomas A Mackenzie, Elisabeth Domingo, Inmaculada Iañez, Matthew B Robers

SLAS Discov· September 2025

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Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase.
Mya D Gough, Matthew B Robers, Cesear R Corona, Ranjit K Mehta, Mukesh K Nyati

SLAS Discov· April 2025

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Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation.
Martin P Schwalm, Amelie Menge, Lewis Elson, Francesco A Greco, Matthew B Robers

ACS Chem Biol· January 2025

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Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.
Ravikumar Jimmidi, Diana Monsivais, Hai Minh Ta, Kiran L Sharma, Kurt M Bohren, Matthew B Robers

Proc Natl Acad Sci U S A· November 2024

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Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Matthew B Robers

J Med Chem· August 2024

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tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis.
Johannes Dopfer, James D Vasta, Susanne Müller, Stefan Knapp, Matthew B Robers

Nat Commun· July 2024

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Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.
Jacob L Capener, James D Vasta, Vittorio L Katis, Ani Michaud, Michael T Beck, Matthew B Robers

bioRxiv· June 2024

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Reversible male contraception by targeted inhibition of serine/threonine kinase 33.
Angela F Ku, Kiran L Sharma, Hai Minh Ta, Courtney M Sutton, Kurt M Bohren, Matthew B Robers

Science· May 2024

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A Method to Conditionally Measure Target Engagement at Intracellular RAS and RAF Complexes.
James D Vasta, Ani Michaud, J Aaron Crapster, Matthew B Robers

Methods Mol Biol· April 2024

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Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis.
Tatsuo Sugawara, Ekaterina Nevedomskaya, Simon Heller, Annika Böhme, Ralf Lesche, Matthew B Robers

Mol Oncol· March 2024

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Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays.
Kelly A Teske, Cesear Corona, Jennifer Wilkinson, Daniel Mamott, David A Good, Matthew B Robers

Cell Chem Biol· February 2024

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Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex.
James D Vasta, Ani Michaud, Chad A Zimprich, Michael T Beck, Matthew R Swiatnicki, Matthew B Robers

Cell Chem Biol· November 2023

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DELs enable the development of BRET probes for target engagement studies in cells.
Kelly A Teske, Wenji Su, Cesear R Corona, Jing Wen, Jason Deng, Matthew B Robers

Cell Chem Biol· August 2023

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NanoBRET™ Live-Cell Kinase Selectivity Profiling Adapted for High-Throughput Screening.
Amanda N Nieman, Kaitlin K Dunn Hoffman, Elizabeth R Dominguez, Jennifer Wilkinson, James D Vasta, Matthew B Robers

Methods Mol Biol· August 2023

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells.
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, Matthew B Robers

bioRxiv· March 2023

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells.
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, Matthew B Robers

Molecules· March 2023

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Small-molecule inhibition of the archetypal UbiB protein COQ8.
Nathan H Murray, Christopher R M Asquith, Zixiang Fang, Michael P East, Naomi Ptak, Matthew B Robers

Nat Chem Biol· February 2023

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Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
Zhengnian Li, Ryosuke Ishida, Yan Liu, Jinhua Wang, Yina Li, Matthew B Robers

Eur J Med Chem· August 2022

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KRAS is vulnerable to reversible switch-II pocket engagement in cells.
James D Vasta, D Matthew Peacock, Qinheng Zheng, Joel A Walker, Ziyang Zhang, Matthew B Robers

Nat Chem Biol· June 2022

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A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Martin P Schwalm, Lena M Berger, Maximilian N Meuter, James D Vasta, Cesear R Corona, Matthew B Robers

Front Cell Dev Biol· May 2022

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Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Florian Wittlinger, David E Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Matthew B Robers

J Med Chem· January 2022

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Resistance to kinase inhibition through shortened target engagement.
Aziz M Rangwala, Benedict-Tilman Berger, Matthew B Robers, Stefan Knapp, Markus A Seeliger

Mol Cell Oncol· January 2022

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Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
Agatha Lyczek, Benedict-Tilman Berger, Aziz M Rangwala, YiTing Paung, Jessica Tom, Matthew B Robers

Proc Natl Acad Sci U S A· November 2021

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