Publications by authors named "Daigen Xu"

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Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models.
Justin Komguep Nono, Kai Fu, Thabo Mpotje, Georgianna Varrone, Nada Abdel Aziz, Daigen Xu

Sci Rep· June 2020

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Discovery of Affinity-Based Probes for Btk Occupancy Assays.
Hui Qiu, Richard Caldwell, Lesley Liu-Bujalski, Andreas Goutopoulos, Reinaldo Jones, Daigen Xu

ChemMedChem· January 2019

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Btk inhibition treats TLR7/IFN driven murine lupus.
Andrew T Bender, Albertina Pereira, Kai Fu, Eileen Samy, Yin Wu, Daigen Xu

Clin Immunol· March 2016

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Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.
Matthew C Lucas, Niala Bhagirath, Eric Chiao, David M Goldstein, Johannes C Hermann, Daigen Xu

J Med Chem· March 2014

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Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy.
Cheng Liao, Jonathan Hsu, Yong Kim, Dong-Qing Hu, Daigen Xu

Arthritis Res Ther· October 2013

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Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase.
Paola Mina-Osorio, Jacob LaStant, Natalie Keirstead, Toni Whittard, Julia Ayala, Daigen Xu

Arthritis Rheum· September 2013

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Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
Fernando Padilla, Niala Bhagirath, Shaoqing Chen, Eric Chiao, David M Goldstein, Daigen Xu

J Med Chem· February 2013

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A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo.
Jun Zhang, Dorin V Preda, Kristine O Vasquez, Jeff Morin, Jeannine Delaney, Daigen Xu

Am J Physiol Renal Physiol· August 2012

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RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents.
Daigen Xu, Yong Kim, Jennifer Postelnek, Minh Diem Vu, Dong-Qing Hu

J Pharmacol Exp Ther· April 2012

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Dual, constrictor-to-dilator, response of the mouse ductus arteriosus to the microsomal prostaglandin E synthase-1 inhibitor, 2-(6-chloro-1H-phenanthro[9,10d]imidazole- 2-yl)isophthalonitrile.
Barbara Baragatti, Francesca Scebba, Daria Sodini, Eleonora Pagni, Enrica Ciofini, Daigen Xu

Neonatology· January 2012

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Trisubstituted ureas as potent and selective mPGES-1 inhibitors.
Jean-François Chiasson, Louise Boulet, Christine Brideau, Anh Chau, David Claveau, Daigen Xu

Bioorg Med Chem Lett· March 2011

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Jason D Burch, Julie Farand, John Colucci, Claudio Sturino, Yves Ducharme, Daigen Xu

Bioorg Med Chem Lett· February 2011

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A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.
Michael J Boyd, Carl Berthelette, Jean-François Chiasson, Patsy Clark, John Colucci, Daigen Xu

Bioorg Med Chem Lett· January 2011

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Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
John Colucci, Michael Boyd, Carl Berthelette, Jean-Francois Chiasson, Zhaoyin Wang, Daigen Xu

Bioorg Med Chem Lett· June 2010

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The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Marc Blouin, Yongxin Han, Jason Burch, Julie Farand, Christophe Mellon, Daigen Xu

J Med Chem· March 2010

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Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
André Giroux, Louise Boulet, Christine Brideau, Anh Chau, David Claveau, Daigen Xu

Bioorg Med Chem Lett· October 2009

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Development of a homogeneous immunoassay for the detection of angiotensin I in plasma using AlphaLISA acceptor beads technology.
Elizabeth Cauchon, Susana Liu, M David Percival, Steve E Rowland, Daigen Xu

Anal Biochem· May 2009

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MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
Daigen Xu, Steven E Rowland, Patsy Clark, André Giroux, Bernard Côté

J Pharmacol Exp Ther· September 2008

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MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
Patsy Clark, Steven E Rowland, Danielle Denis, Marie-Claude Mathieu, Rino Stocco, Daigen Xu

J Pharmacol Exp Ther· May 2008

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Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis.
Mei Chen, Eric Boilard, Peter A Nigrovic, Patsy Clark, Daigen Xu

Arthritis Rheum· May 2008

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Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Masako Nakanishi, David C Montrose, Patsy Clark, Prashant R Nambiar, Glenn S Belinsky, Daigen Xu

Cancer Res· May 2008

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.
Jason D Burch, Michel Belley, Réjean Fortin, Denis Deschênes, Mario Girard, Daigen Xu

Bioorg Med Chem Lett· March 2008

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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Bernard Côté, Louise Boulet, Christine Brideau, David Claveau, Diane Ethier, Daigen Xu

Bioorg Med Chem Lett· December 2007

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Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species.
Steven E Rowland, Patsy Clark, Robert Gordon, Anne K Mullen, Jocelyne Guay, Daigen Xu

Eur J Pharmacol· April 2007

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Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis.
Anne-Marie Pulichino, Steve Rowland, Tom Wu, Patsy Clark, Daigen Xu

J Pharmacol Exp Ther· December 2006

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