Publications by authors named "Stephen M Soisson"

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A non-canonical mechanism of GPCR activation.
Alexander S Powers, Aasma Khan, Joseph M Paggi, Naomi R Latorraca, Sarah Souza, Stephen M Soisson

Nat Commun· November 2024

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Biostructural, biochemical and biophysical studies of mutant IDH1.
Mark A McCoy, Jun Lu, F Richard Miller, Stephen M Soisson, Michael H Lam

Nat Commun· September 2024

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Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates.
Chengwei Wu, Izzat T Raheem, Debbie D Nahas, Michael Citron, Peter S Kim, Stephen M Soisson

Proc Natl Acad Sci U S A· May 2024

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Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels.
Yun-Ting Chen, Mee Ra Hong, Xin-Jun Zhang, James Kostas, Yuxing Li, Stephen M Soisson

Proc Natl Acad Sci U S A· October 2023

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A non-canonical mechanism of GPCR activation.
Alexander S Powers, Aasma Khan, Joseph M Paggi, Naomi R Latorraca, Sarah Souza, Stephen M Soisson

bioRxiv· August 2023

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Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis.
Anthony T Ginnetti, Daniel V Paone, Kausik K Nanda, Jing Li, Marina Busuek, Stephen M Soisson

Bioorg Med Chem Lett· October 2022

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Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Stephen M Soisson

Nat Commun· May 2021

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Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Robert P Hayes, Mee Ra Heo, Mark Mason, John Reid, Christine Burlein, Stephen M Soisson

Nat Commun· May 2021

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Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy.
Noel J Byrne, Amy C Lee, James Kostas, John C Reid, Andrea T Partridge, Stephen M Soisson

Protein Expr Purif· March 2021

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Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
Chuan Hong, Noel J Byrne, Beata Zamlynny, Srivanya Tummala, Li Xiao, Stephen M Soisson

Nat Commun· February 2021

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Whitney L Petrilli, Gregory C Adam, Roman S Erdmann, Pravien Abeywickrema, Vijayalakshmi Agnani, Stephen M Soisson

Cell Chem Biol· February 2021

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Identification of potent inhibitors of the sortilin-progranulin interaction.
Shawn J Stachel, Anthony T Ginnetti, Scott A Johnson, Paige Cramer, Yi Wang, Stephen M Soisson

Bioorg Med Chem Lett· September 2020

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Whitney L Petrilli, Gregory C Adam, Roman S Erdmann, Pravien Abeywickrema, Vijayalakshmi Agnani, Stephen M Soisson

Cell Chem Biol· January 2020

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A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein.
Aimin Tang, Zhifeng Chen, Kara S Cox, Hua-Poo Su, Cheryl Callahan, Stephen M Soisson

Nat Commun· September 2019

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Jun Lu, Noel Byrne, John Wang, Gerard Bricogne, Frank K Brown, Stephen M Soisson

Nat Struct Mol Biol· July 2017

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Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.
Nathaniel L Elsen, Sangita B Patel, Rachael E Ford, Dawn L Hall, Fred Hess, Stephen M Soisson

Nat Chem Biol· June 2017

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Structural basis for selectivity and diversity in angiotensin II receptors.
Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L White, Stephen M Soisson

Nature· April 2017

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Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Hua-Poo Su, Keith Rickert, Christine Burlein, Kartik Narayan, Marina Bukhtiyarova, Stephen M Soisson

Proc Natl Acad Sci U S A· January 2017

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Identification of an allosteric binding site for RORγt inhibition.
Marcel Scheepstra, Seppe Leysen, Geert C van Almen, J Richard Miller, Jennifer Piesvaux, Stephen M Soisson

Nat Commun· December 2015

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Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
Samantha J Allen, Gopal Parthasarathy, Paul L Darke, Ronald E Diehl, Rachael E Ford, Stephen M Soisson

J Biol Chem· August 2015

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Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode.
Jun Lu, Sangita Patel, Nandini Sharma, Stephen M Soisson, Ryuta Kishii

ACS Chem Biol· September 2014

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Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer.
Gina M Clayton, Daniel J Klein, Keith W Rickert, Sangita B Patel, Maria Kornienko, Stephen M Soisson

J Biol Chem· November 2013

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Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
Alan B Northrup, Matthew H Katcher, Michael D Altman, Melissa Chenard, Matthew H Daniels, Stephen M Soisson

J Med Chem· March 2013

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Mechanism of action of the cell-division inhibitor PC190723: modulation of FtsZ assembly cooperativity.
Nathaniel L Elsen, Jun Lu, Gopal Parthasarathy, John C Reid, Sujata Sharma, Stephen M Soisson

J Am Chem Soc· August 2012

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Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.
Christopher M Tan, Alex G Therien, Jun Lu, Sang H Lee, Alexandre Caron, Stephen M Soisson

Sci Transl Med· March 2012

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