Publications by authors named "Fred Hess"

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Atypical Presentation of Primary Osteosarcoma of the Lumbar Spine with Caval Tumor Thrombus in a 17-Year-Old Male: A Case Report.
Matthew Rae, Joseph Wong, Justin Tunis, W Fred Hess, Jerad M Gardner

Curr Sports Med Rep· November 2022

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MK-8719, a Novel and Selective -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy.
Xiaohai Wang, Wenping Li, Jacob Marcus, Michelle Pearson, Lixin Song, J Fred Hess

J Pharmacol Exp Ther· August 2020

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Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
Harold G Selnick, J Fred Hess, Cuyue Tang, Kun Liu, Joel B Schachter

J Med Chem· November 2019

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Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.
Xiaohai Wang, Karen Smith, Michelle Pearson, Anna Hughes, Mali L Cosden, J Fred Hess

PLoS One· July 2018

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Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.
Nathaniel L Elsen, Sangita B Patel, Rachael E Ford, Dawn L Hall, Fred Hess

Nat Chem Biol· June 2017

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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.
Nicholas B Hastings, Xiaohai Wang, Lixin Song, Brent D Butts, Diane Grotz, J Fred Hess

Mol Neurodegener· May 2017

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Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).
Abbas M Walji, Eric D Hostetler, Harold Selnick, Zhizhen Zeng, Patricia Miller, Fred J Hess

J Med Chem· May 2016

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Early outcomes and complications of posterior vertebral column resection.
Elias C Papadopoulos, Oheneba Boachie-Adjei, W Fred Hess, Francisco J Sanchez Perez-Grueso, Ferran Pellisé

Spine J· May 2015

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Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Lixin Song, Sherry X Lu, Xuesong Ouyang, Jerry Melchor, Julie Lee, J Fred Hess

Mol Neurodegener· March 2015

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A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease.
Emmanuel Le Poul, Christelle Boléa, Francoise Girard, Sonia Poli, Delphine Charvin, Fred Hess

J Pharmacol Exp Ther· October 2012

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Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.
Sophie Parmentier-Batteur, Eleftheria N Finger, Raghu Krishnan, Hemaka A Rajapakse, John M Sanders, J Fred Hess

J Neurochem· September 2011

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Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.
Jens Brodbeck, Jim McGuire, Zhaoping Liu, Anke Meyer-Franke, Maureen E Balestra, Fred Hess

J Biol Chem· May 2011

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Delayed presentation of a traumatic spinal epidural hematoma in a preadolescent: a case report.
Andrew A R Lehman, Mark E McKenna, Ronald Wisneski, W Fred Hess

J Bone Joint Surg Am· April 2011

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PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ.
Laura S Lubbers, Blake A Rowe, Lisa M Hodge, Susan E Browne, Richard Gundersdorf, Fred J Hess

J Pharmacol Toxicol Methods· December 2010

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Genome-wide microarray analysis of the differential neuroprotective effects of antioxidants in neuroblastoma cells overexpressing the familial Parkinson's disease alpha-synuclein A53T mutation.
Lei Ma, Tracy T Cao, Geeta Kandpal, Lee Warren, J Fred Hess

Neurochem Res· January 2010

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Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy.
Jonathan T Kern, Mark Hannink, J Fred Hess

Curr Top Med Chem· July 2007

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Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.
Scott D Kuduk, Christina N Di Marco, Ronald K Chang, Michael R Wood, Kathy M Schirripa, J Fred Hess

J Med Chem· January 2007

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Identification of the critical residues of bradykinin receptor B1 for interaction with the kinins guided by site-directed mutagenesis and molecular modeling.
Sookhee N Ha, Pat J Hey, Rick W Ransom, Mark G Bock, Dai-Shi Su, J Fred Hess

Biochemistry· December 2006

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Generation and characterization of a humanized bradykinin B1 receptor mouse.
J Fred Hess, Richard Z Chen, Patricia Hey, Robert Breese, Ray S L Chang

Biol Chem· February 2006

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Increased nuclear factor-erythroid 2 p45-related factor 2 activity protects SH-SY5Y cells against oxidative damage.
Tracy T Cao, Lei Ma, Geeta Kandpal, Lee Warren, J Fred Hess

J Neurochem· October 2005

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Targeting the metabotropic glutamate receptor mGluR4 for the treatment of diseases of the central nervous system.
Michael J Marino, J Fred Hess, Nigel Liverton

Curr Top Med Chem· October 2005

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Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1.
Sookhee N Ha, Pat J Hey, Rick W Ransom, C Meacham Harrell, Kathryn L Murphy, Fred J Hess

Biochem Biophys Res Commun· May 2005

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.
Sheri L Holmen, Troy A Giambernardi, Cassandra R Zylstra, Bree D Buckner-Berghuis, James H Resau, J Fred Hess

J Bone Miner Res· December 2004

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Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies.
Dai-Shi Su, M Kristine Markowitz, Kathy L Murphy, Bang-Lin Wan, Matthew M Zrada, J Fred Hess

Bioorg Med Chem Lett· December 2004

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Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist.
Richard W Ransom, Charles M Harrell, Duane R Reiss, Kathryn L Murphy, Raymond S L Chang, J Fred Hess

Eur J Pharmacol· September 2004

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