Publications by authors named "Jerry Melchor"

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The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions.
Akimasa Hayashi, Yu-Jui Ho, Alvin P Makohon-Moore, Amanda Zucker, Jungeui Hong, Jerry P Melchor

Cancer Res Commun· October 2025

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Pembrolizumab and Olaparib (POLAR) Maintenance Therapy in Metastatic Pancreatic Cancer With or Without Homologous Repair Deficiency: A Biomarker Selected Phase II Trial.
Wungki Park, Catherine O'Connor, Joanne Chou, Marc Hilmi, Zeynep Tarcan, Jerry Melchor

Res Sq· September 2025

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Combination immunohistochemistry for CK5/6, p63, GATA6, and HNF4a predicts clinical outcome in treatment-naïve pancreatic ductal adenocarcinoma.
Takahiro Shibayama, Akimasa Hayashi, Masao Toki, Keiichiro Kitahama, Yu-Jui Ho, Jerry P Melchor

Sci Rep· July 2024

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Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.
Michael D Kinnaman, Simone Zaccaria, Alvin Makohon-Moore, Brian Arnold, Max F Levine, Jerry P Melchor

Cancer Res· November 2023

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Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma.
Michael D Kinnaman, Simone Zaccaria, Alvin Makohon-Moore, Brian Arnold, Max Levine, Jerry Melchor

bioRxiv· January 2023

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Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
Kamini Singh, Jianan Lin, Nicolas Lecomte, Prathibha Mohan, Askan Gokce, Jerry P Melchor

Cancer Res· April 2021

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Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.
Olivera Grbovic-Huezo, Kenneth L Pitter, Nicolas Lecomte, Joseph Saglimbeni, Gokce Askan, Jerry P Melchor

Proc Natl Acad Sci U S A· December 2020

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Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Akimasa Hayashi, Aslihan Yavas, Caitlin A McIntyre, Yu-Jui Ho, Amanda Erakky, Jerry P Melchor

Mod Pathol· September 2020

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MK-8719, a Novel and Selective -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy.
Xiaohai Wang, Wenping Li, Jacob Marcus, Michelle Pearson, Lixin Song, Jerry P Melchor

J Pharmacol Exp Ther· August 2020

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Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.
Luisa F Escobar-Hoyos, Alex Penson, Ram Kannan, Hana Cho, Chun-Hao Pan, Jerry P Melchor

Cancer Cell· August 2020

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The Evolutionary Origins of Recurrent Pancreatic Cancer.
Hitomi Sakamoto, Marc A Attiyeh, Jeffrey M Gerold, Alvin P Makohon-Moore, Akimasa Hayashi, Jerry P Melchor

Cancer Discov· June 2020

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A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma.
Akimasa Hayashi, Jun Fan, Ruoyao Chen, Yu-Jui Ho, Alvin P Makohon-Moore, Jerry P Melchor

Nat Cancer· January 2020

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PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk.
Smrita Sinha, Ya-Yuan Fu, Adrien Grimont, Maren Ketcham, Kelly Lafaro, Jerry P Melchor

Cancer Res· April 2017

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Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Lixin Song, Sherry X Lu, Xuesong Ouyang, Jerry Melchor, Julie Lee

Mol Neurodegener· March 2015

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Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease.
Justin Paul, Sidney Strickland, Jerry P Melchor

J Exp Med· August 2007

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Modulation of sympathetic activity by tissue plasminogen activator is independent of plasminogen and urokinase.
Ulrich Schaefer, Sandra Vorlova, Takuji Machida, Jerry P Melchor, Sidney Strickland

J Pharmacol Exp Ther· July 2007

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Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus.
Robert Pawlak, B S Shankaranarayana Rao, Jerry P Melchor, Sumantra Chattarji, Bruce McEwen

Proc Natl Acad Sci U S A· December 2005

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Tissue plasminogen activator in central nervous system physiology and pathology.
Jerry P Melchor, Sidney Strickland

Thromb Haemost· April 2005

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Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.
Robert Pawlak, Jerry P Melchor, Tomasz Matys, Anna E Skrzypiec, Sidney Strickland

Proc Natl Acad Sci U S A· January 2005

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The possible role of tissue-type plasminogen activator (tPA) and tPA blockers in the pathogenesis and treatment of Alzheimer's disease.
Jerry P Melchor, Robert Pawlak, Zulin Chen, Sidney Strickland

J Mol Neurosci· December 2003

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The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.
Jerry P Melchor, Robert Pawlak, Sidney Strickland

J Neurosci· October 2003

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Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior.
Robert Pawlak, Ana Maria Magarinos, Jerry Melchor, Bruce McEwen, Sidney Strickland

Nat Neurosci· February 2003

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Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor.
William E Van Nostrand, Jerry P Melchor, Galina Romanov, Kelly Zeigler, Judianne Davis

Ann N Y Acad Sci· November 2002

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Localization of a fibrillar amyloid beta-protein binding domain on its precursor.
William E Van Nostrand, Jerry P Melchor, David M Keane, Susan M Saporito-Irwin, Galina Romanov

J Biol Chem· September 2002

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