Publications by authors named "Gopal Parthasarathy"

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Brownian dynamics simulations of telechelic polymer - latex suspensions under steady shear.
Sriram Krishnamurthy, Gopal Parthasarathy, Ronald G Larson, Ethayaraja Mani

Soft Matter· April 2023

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Whitney L Petrilli, Gregory C Adam, Roman S Erdmann, Pravien Abeywickrema, Vijayalakshmi Agnani, Gopal Parthasarathy

Cell Chem Biol· February 2021

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Identification of potent inhibitors of the sortilin-progranulin interaction.
Shawn J Stachel, Anthony T Ginnetti, Scott A Johnson, Paige Cramer, Yi Wang, Gopal Parthasarathy

Bioorg Med Chem Lett· September 2020

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Discovery of -(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases.
Hongjun Zhang, Blair T Lapointe, Neville Anthony, Rita Azevedo, Jos Cals, Gopal Parthasarathy

ACS Med Chem Lett· February 2020

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Whitney L Petrilli, Gregory C Adam, Roman S Erdmann, Pravien Abeywickrema, Vijayalakshmi Agnani, Gopal Parthasarathy

Cell Chem Biol· January 2020

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Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species.
Shawn J Stachel, Melissa S Egbertson, Jenny Wai, Michelle Machacek, Dawn M Toolan, Gopal Parthasarathy

Bioorg Med Chem Lett· April 2018

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The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Ashley B Forster, Pravien Abeywickrema, Jaime Bunda, Christopher D Cox, Tamara D Cabalu, Gopal Parthasarathy

Bioorg Med Chem Lett· December 2017

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Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
Shawn J Stachel, Celina Zerbinatti, Michael T Rudd, Mali Cosden, Sokreine Suon, Gopal Parthasarathy

J Med Chem· April 2016

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Identification of an allosteric binding site for RORγt inhibition.
Marcel Scheepstra, Seppe Leysen, Geert C van Almen, J Richard Miller, Jennifer Piesvaux, Gopal Parthasarathy

Nat Commun· December 2015

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Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
Samantha J Allen, Gopal Parthasarathy, Paul L Darke, Ronald E Diehl, Rachael E Ford

J Biol Chem· August 2015

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Mechanism of action of the cell-division inhibitor PC190723: modulation of FtsZ assembly cooperativity.
Nathaniel L Elsen, Jun Lu, Gopal Parthasarathy, John C Reid, Sujata Sharma

J Am Chem Soc· August 2012

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Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.
Christopher M Tan, Alex G Therien, Jun Lu, Sang H Lee, Alexandre Caron, Gopal Parthasarathy

Sci Transl Med· March 2012

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