Publications by authors named "Christopher D Cox"

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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
Mark E Layton, Jeffrey C Kern, Timothy J Hartingh, William D Shipe, Izzat Raheem, Christopher D Cox

J Med Chem· January 2023

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Stem Cell-based therapies for COVID-19-related acute respiratory distress syndrome.
Hoi Wa Ngai, Dae Hong Kim, Mohamed Hammad, Margarita Gutova, Karen Aboody, Christopher D Cox

J Cell Mol Med· May 2022

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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
Douglas C Beshore, Gregory C Adam, Richard J O Barnard, Christine Burlein, Steven N Gallicchio, Christopher D Cox

ACS Med Chem Lett· April 2021

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Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
Marina Bukhtiyarova, Erica M Cook, Paula J Hancock, Alan W Hruza, Anthony W Shaw, Christopher D Cox

ACS Med Chem Lett· January 2021

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In Quest of Pathognomonic/Endophenotypic Markers of Attention Deficit Hyperactivity Disorder (ADHD): Potential of EEG-Based Frequency Analysis and ERPs to Better Detect, Prevent and Manage ADHD.
Priya Miranda, Christopher D Cox, Michael Alexander, Slav Danev, Jonathan R T Lakey

Med Devices (Auckl)· May 2020

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Targeted next-generation sequencing of 565 neuro-oncology patients at UCLA: A single-institution experience.
Matthew S Ji, Blaine S C Eldred, Regina Liu, Sean T Pianka, Donna Molaie, Christopher D Cox

Neurooncol Adv· January 2020

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SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation.
Fei Liu, Christopher D Cox, Reshmi Chowdhury, Laura Dovek, Huytram Nguyen

J Neurooncol· May 2019

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D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced Promoter Methylation.
Tie Li, Christopher D Cox, Byram H Ozer, Nhung T Nguyen, HuyTram N Nguyen

Mol Cancer Res· June 2018

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The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Ashley B Forster, Pravien Abeywickrema, Jaime Bunda, Christopher D Cox, Tamara D Cabalu

Bioorg Med Chem Lett· December 2017

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Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193.
Eric D Hostetler, Hong Fan, Aniket D Joshi, Zhizhen Zeng, Waisi Eng, Christopher D Cox

Mol Imaging Biol· August 2016

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Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.
Anthony J Roecker, Christopher D Cox, Paul J Coleman

J Med Chem· January 2016

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Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Izzat T Raheem, John D Schreier, Joy Fuerst, Liza Gantert, Eric D Hostetler, Christopher D Cox

Bioorg Med Chem Lett· January 2016

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Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Christopher D Cox, Eric D Hostetler, Broc A Flores, Jeffrey L Evelhoch, Hong Fan

Bioorg Med Chem Lett· November 2015

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Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.
William D Shipe, Steven S Sharik, James C Barrow, Georgia B McGaughey, Cory R Theberge, Christopher D Cox

J Med Chem· October 2015

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Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Izzat T Raheem, Michael J Breslin, Joseph Bruno, Tamara D Cabalu, Andrew Cooke, Christopher D Cox

Bioorg Med Chem Lett· February 2015

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Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Thomas S Reger, M Christa Mattern, Swati P Mercer, Jeffrey M Bergman, Christopher D Cox

Bioorg Med Chem Lett· October 2014

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Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Swati P Mercer, John D Schreier, Christopher D Cox, Mark E Fraley

ChemMedChem· February 2014

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Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance.
Andrea R Nawrocki, Carlos G Rodriguez, Dawn M Toolan, Olga Price, Melanie Henry, Christopher D Cox

Diabetes· January 2014

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Shaping suvorexant: application of experimental and theoretical methods for driving synthetic designs.
Georgia McGaughey, Christopher I Bayly, Christopher D Cox, John D Schreier, Michael J Breslin

J Comput Aided Mol Des· January 2014

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The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.
Sean M Smith, Jason M Uslaner, Christopher D Cox, Sarah L Huszar, Christopher E Cannon

Neuropharmacology· January 2013

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Syntheses, thermal reactivities, and computational studies of aryl-fused quinoxalenediynes: effect of extended benzannelation on Bergman cyclization energetics.
John D Spence, Andro C Rios, Megan A Frost, Claire M McCutcheon, Christopher D Cox

J Org Chem· November 2012

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Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Izzat T Raheem, Michael J Breslin, Christine Fandozzi, Joy Fuerst, Nicole Hill, Christopher D Cox

Bioorg Med Chem Lett· September 2012

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Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Paul J Coleman, John D Schreier, Christopher D Cox, Michael J Breslin, David B Whitman

ChemMedChem· March 2012

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Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.
Christopher J Winrow, Anthony L Gotter, Christopher D Cox, Pamela L Tannenbaum, Susan L Garson

Neuropharmacology· February 2012

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Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans.
Frank R Sharp, Glen C Jickling, Boryana Stamova, Yingfang Tian, Xinhua Zhan, Christopher D Cox

J Cereb Blood Flow Metab· July 2011

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