Publications by authors named "Keith W Rickert"

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Development and validation of a multiplex immunoassay for the simultaneous quantification of type-specific IgG antibodies to E6/E7 oncoproteins of HPV16 and HPV18.
Hans Layman, Keith W Rickert, Susan Wilson, Anastasia A Aksyuk, Jill M Dunty

PLoS One· June 2020

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Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis.
Gabriela M Marchetti, Timothy J Burwell, Norman C Peterson, Jennifer A Cann, Richard N Hanna, Keith W Rickert

Commun Biol· April 2020

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Antibody Fragment F(ab') Targeting Caveolae-Associated Protein PV1 for Selective Kidney Targeting and Retention.
Qing Li, Norman Peterson, Richard N Hanna, Kyle Kuszpit, Jason White, Keith W Rickert

Mol Pharm· February 2020

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Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.
Daniel A Cannon, Lu Shan, Qun Du, Lena Shirinian, Keith W Rickert

PLoS Comput Biol· May 2019

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Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension.
Qing Li, Allison Barrett, Balakumar Vijayakrishnan, Arnaud Tiberghien, Rhiannon Beard, Keith W Rickert

Bioconjug Chem· April 2019

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Tumor uptake of pegylated diabodies: Balancing systemic clearance and vascular transport.
Qing Li, Jason B White, Norman C Peterson, Keith W Rickert, Christopher O Lloyd

J Control Release· June 2018

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A hingeless Fc fusion system for site-specific cleavage by IdeS.
Shabazz Novarra, Luba Grinberg, Keith W Rickert, Arnita Barnes, Susan Wilson

MAbs· December 2017

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Combining phage display with de novo protein sequencing for reverse engineering of monoclonal antibodies.
Keith W Rickert, Luba Grinberg, Robert M Woods, Susan Wilson, Michael A Bowen

MAbs· December 2016

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Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.
Victoria D Kutilek, Christine L Andrews, Matthew P Richards, Zangwei Xu, Tianxiao Sun, Keith W Rickert

J Biomol Screen· July 2016

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Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
Samantha J Allen, Gopal Parthasarathy, Paul L Darke, Ronald E Diehl, Rachael E Ford, Keith W Rickert

J Biol Chem· August 2015

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Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Sheo B Singh, David E Kaelin, Jin Wu, Lynn Miesel, Christopher M Tan, Keith W Rickert

Bioorg Med Chem Lett· May 2015

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Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.
Sheo B Singh, David E Kaelin, Jin Wu, Lynn Miesel, Christopher M Tan, Keith W Rickert

ACS Med Chem Lett· May 2014

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Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer.
Gina M Clayton, Daniel J Klein, Keith W Rickert, Sangita B Patel, Maria Kornienko

J Biol Chem· November 2013

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Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
Alan B Northrup, Matthew H Katcher, Michael D Altman, Melissa Chenard, Matthew H Daniels, Keith W Rickert

J Med Chem· March 2013

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Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
Jason D Katz, James P Jewell, David J Guerin, Jongwon Lim, Christopher J Dinsmore, Keith W Rickert

J Med Chem· June 2011

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Structural basis for selective small molecule kinase inhibition of activated c-Met.
Keith W Rickert, Sangita B Patel, Timothy J Allison, Noel J Byrne, Paul L Darke

J Biol Chem· April 2011

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Expression, purification and crystallization of human prolylcarboxypeptidase.
Pravien D Abeywickrema, Sangita B Patel, Noel J Byrne, Ronald E Diehl, Dawn L Hall, Keith W Rickert

Acta Crystallogr Sect F Struct Biol Cryst Commun· June 2010

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Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.
Stephen M Soisson, Sangita B Patel, Pravien D Abeywickrema, Noel J Byrne, Ronald E Diehl, Keith W Rickert

BMC Struct Biol· June 2010

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Structure of human prostasin, a target for the regulation of hypertension.
Keith W Rickert, Paul Kelley, Noel J Byrne, Ronald E Diehl, Dawn L Hall

J Biol Chem· December 2008

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Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
Keith W Rickert, Michael Schaber, Maricel Torrent, Lou Anne Neilson, Edward S Tasber

Arch Biochem Biophys· January 2008

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Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.
John T Sisko, Thomas J Tucker, Mark T Bilodeau, Carolyn A Buser, Patrice A Ciecko, Keith W Rickert

Bioorg Med Chem Lett· March 2006

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Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel.
Mark T Bilodeau, Adrienne E Balitza, Timothy J Koester, Peter J Manley, Leonard D Rodman, Keith W Rickert

J Med Chem· December 2004

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The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase.
Mark T Bilodeau, Leonard D Rodman, Georgia B McGaughey, Kathleen E Coll, Timothy J Koester, Keith W Rickert

Bioorg Med Chem Lett· June 2004

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2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.
Peter J Manley, Adrienne E Balitza, Mark T Bilodeau, Kathleen E Coll, George D Hartman, Keith W Rickert

Bioorg Med Chem Lett· May 2003

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